Corrosive Esophagitis and Gastritis Induced by Glutaraldehyde Ingestion

Jun, Donghwan; Kim, Hye-Jin; Lee, Hyun Suk; Yoon, Hong Jip; Park, Jae Yong; Kim, Beom Jin; Kim, Jae Gyu

doi:10.7704/kjhugr.2020.0027

Cited by 2 publications

(8 citation statements)

References 16 publications

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“…We reported only 22 cases over 10 years. The incidence is three times higher in under-developed and developing countries than in the Romanian population [ 4 , 8 , 18 , 21 ]. ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…Epithelial dysplasia has been assumed to be a precancerous lesion. For alkaline ingestion, in particular, subsequent development of squamous cell carcinoma has been reported to occur approximately 40 years after the initial injury [ 4 , 8 ]. The damages produced by these chemicals are related to different mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…This kind of necrosis leads to the destruction of esophageal mucosa within a few minutes. Next days after the alkali consumption, mucosal injury is worsened by small vessel thrombosis, bacterial invasion, collagen deposition and ulcer production [ 8 , 9 ]. During this period, there is a high risk of perforation.…”

Section: Introductionmentioning

confidence: 99%

“…However, in cases of acidic substances, the esophagus can be spared while the stomach is severely injured. The esophageal protective eschar and lower surface tension allow acids to bypass the esophagus [ 8 , 9 , 10 ]. The injury depends on the concentration, quantity, type, and time of contact between chemical substances and the esophagus and pH value.…”

Section: Introductionmentioning

confidence: 99%

“…Agents in the solid state are involved in mouth and pharynx lesions due to their quick attachment to those sites, while agents in the fluid state pass through them, causing important damage to the esophagus and stomach. Corrosive esophagitis affects in generally the middle and lower parts of the esophagus [ 8 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Endoscopic Grading as a Predictor to Develop Strictures in Corrosive Esophagitis in Children

Tișa

Pepelea

Pîrvan

et al. 2023

JCM

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Introduction. The incidence of corrosive esophagitis, also known as caustic esophagitis in children, is still increasing in developing countries, according to different clinical reports. Acids and alkalis are, in the same manner, involved in the pathogenesis of corrosive esophagitis in children. The aim of our study was to determine the incidence and endoscopic grading of corrosive esophagitis in a cohort of children from a developing country. Materials and methods. We performed a retrospective analysis of all pediatric patients who were admitted for corrosive ingestion at Pediatric Clinic II, Emergency Hospital for Children, Cluj-Napoca, over 10 years. Results. A total of 22 patients consisting of 13 (59.09%) girls and 9 boys (40.91%) were found in the present research. The majority of children lived in rural areas (69.2%). The results of laboratory tests were not well correlated with the degree of the injury. White blood cell counts over 20,000 cells/mm3, an increase in the C-reactive protein level and hypoalbuminemia were noticed only in three patients with strictures. The lesions were associated with increased levels of the pro-inflammatory cytokines, including interleukin (IL)-2, IL-5 and Interferon-gamma. Severe late complications such as strictures have been noticed in children with grade 3A injuries. The endoscopic dilation was done after the six months endoscopy. None of the patients treated with endoscopic dilation required surgical intervention for esophageal or pyloric perforation or dilation failure. The majority of complications (such as malnutrition) were noticed in children with grade 3A injuries. In consequence, prolonged hospitalization has been required. The second endoscopy (done six months after ingestion) revealed stricture as the most common late complication (n = 13, 60.60%: eight patients with grade 2B and five with grade 3A). Conclusion. There is a low incidence of corrosive esophagitis in children in our geographic area. Endoscopic grading is a predictor of late complications such as strictures. Grade 2B and 3A corrosive esophagitis are likely to develop strictures. It is crucial to avoid strictures and to prevent malnutrition.

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“…We reported only 22 cases over 10 years. The incidence is three times higher in under-developed and developing countries than in the Romanian population [ 4 , 8 , 18 , 21 ]. ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Endoscopic Grading as a Predictor to Develop Strictures in Corrosive Esophagitis in Children

Tișa

Pepelea

Pîrvan

et al. 2023

JCM

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Severe Corrosive Injury Secondary to Chlorine Bleach Ingestion: A Case Report

Choi

2024

Korean J Helicobacter Up Gastrointest Res

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Corrosive injuries to the upper gastrointestinal tract, particularly those caused by alkaline substances, often result in more severe and deeper tissue injuries than those observed after ingestion of acidic substances. We report a case of severe corrosive injury following ingestion of chlorine bleach (200 mL), an alkaline agent. Initial endoscopic evaluation revealed severe esophageal and gastric injuries with necrosis (Zargar grade 3b), without any signs of perforation. The treatment plan included prolonged fasting with total parenteral nutrition, and enteral feeding was initiated via jejunostomy 1 month after hospitalization. The patient was hospitalized and discharged on several occasions until we observed complete healing of the esophagus and stomach. Follow-up endoscopy performed 4 months after the injury showed improvement in the esophageal wall; however, severe stenosis prevented oral intake. Therefore, the patient underwent surgical intervention, including esophagectomy, total gastrectomy, and esophagocolojejunostomy, 7 months post-injury. Since the initial surgery, the patient underwent repeat wound revision procedures, percutaneous drainage, reconstruction, and bougienation owing to anastomotic leakage, infection, and stenosis for approximately a year. The patient received oral and jejunostomy tube feeding for approximately 2.5 years after the initial injury. Early endoscopy was useful to confirm the severity and predict the prognosis of corrosive injuries in this case. Severe corrosive injuries following ingestion of alkaline substances are associated with poor clinical prognosis, as anticipated. Caution is warranted for the diagnosis and treatment of this condition.

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Corrosive Esophagitis and Gastritis Induced by Glutaraldehyde Ingestion

Cited by 2 publications

References 16 publications

Endoscopic Grading as a Predictor to Develop Strictures in Corrosive Esophagitis in Children

Endoscopic Grading as a Predictor to Develop Strictures in Corrosive Esophagitis in Children

Severe Corrosive Injury Secondary to Chlorine Bleach Ingestion: A Case Report

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