Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia

Han, Yong; Yang, Yongfeng; Zhou, Zhe; Xu, Jin; Shi, Han; Shao, Ming; Song, Meng; Su, Xi; Wang, Qi; Liu, Qing; Li, Wenqiang; Lv, Luxian

doi:10.1016/j.nicl.2023.103451

Cited by 2 publications

(1 citation statement)

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“…Since the cerebral cortex is universally regarded as an advanced hub for cognition and consciousness, many neurological diseases and psychosis have been definitively linked to substantial structural alterations within the cerebral cortex. Examples include schizophrenia patients who had significant variations in 55 regions of cortical thickness, 23 regions of the volume, seven regions of the area, and 55 regions of local gyrification index than healthy individuals ( Han et al, 2023 ). Children with autism spectrum disorder also experience a higher empathizing-systemizing difference than children without autism, which shares a significant negative association with the gyrification in the left lateral occipital cortex ( Pan et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study

Yang

Liu

et al. 2023

Front. Neurosci.

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IntroductionNumerous studies have suggested a connection between circadian rhythm and neurological disorders with cognitive and consciousness impairments in humans, yet little evidence stands for a causal relationship between circadian rhythm and the brain cortex.MethodsThe top 10,000 morningness-related single-nucleotide polymorphisms of the Genome-wide association study (GWAS) summary statistics were used to filter the instrumental variables. GWAS summary statistics from the ENIGMA Consortium were used to assess the causal relationship between morningness and variates like cortical thickness (TH) or surficial area (SA) on the brain cortex. The inverse-variance weighted (IVW) and weighted median (WM) were used as the major estimates whereas MR-Egger, MR Pleiotropy RESidual Sum and Outlier, leave-one-out analysis, and funnel-plot were used for heterogeneity and pleiotropy detecting.ResultsRegionally, morningness decreased SA of the rostral middle frontal gyrus with genomic control (IVW: β = −24.916 mm, 95% CI: −47.342 mm to −2.490 mm, p = 0.029. WM: β = −33.208 mm, 95% CI: −61.933 mm to −4.483 mm, p = 0.023. MR Egger: β < 0) and without genomic control (IVW: β = −24.581 mm, 95% CI: −47.552 mm to −1.609 mm, p = 0.036. WM: β = −32.310 mm, 95% CI: −60.717 mm to −3.902 mm, p = 0.026. MR Egger: β < 0) on a nominal significance, with no heterogeneity or no outliers.Conclusions and implicationsCircadian rhythm causally affects the rostral middle frontal gyrus; this sheds new light on the potential use of MRI in disease diagnosis, revealing the significance of circadian rhythm on the progression of disease, and might also suggest a fresh therapeutic approach for disorders related to the rostral middle frontal gyrus-related.

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Section: Introductionmentioning

confidence: 99%