Cortical and subcortical activation with monaural monosyllabic stimulation by functional MRI

Suzuki, Mikio; Kitano, Hiroya; Kitanishi, Tuyoshi; Itou, Ryuta; Shiino, Akihiko; Nishida, Yasuhiro; Yazawa, Yoshiro; Ogawa, Fumio; Kitajima, Kazutomo

doi:10.1016/s0378-5955(01)00367-7

Cited by 45 publications

(23 citation statements)

References 19 publications

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“…It has repeatedly been shown that monaurally perceived sound results in a response lateralized to the contralateral hemisphere (Suzuki et al, 2002;Langers et al, 2005; this work, Fig. 3a-b).…”

Section: Cortical Activity Due To Gazesupporting

confidence: 64%

“…Changes in this loop have been proposed by Llinás and et al, (1999) to account for the observation that tinnitus is associated with increased theta and decreased alpha activity of the brain (Weisz et al, 2011). They proposed that prolonged hyperpolarization of cells in the thalamus produces low-threshold spike bursts and locks the related thalamocortical loops in lowfrequency theta resonance.…”

Section: Cortical Activity Due To Gazementioning

confidence: 97%

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The Relation between Perception and Brain Activity in Gaze-Evoked Tinnitus

et al. 2012

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Tinnitus is a phantom sound percept that can be severely disabling. Its pathophysiology is poorly understood, partly due to the inability to objectively measure neural correlates of tinnitus. Gaze-evoked tinnitus (GET) is a rare form of tinnitus that may arise after vestibular schwannoma removal. Subjects typically describe tinnitus in the deaf ear on the side of the surgery that can be modulated by peripheral eye gaze. This phenomenon offers a unique opportunity to study the relation between tinnitus and brain activity. We used functional magnetic resonance imaging in humans to show that in normal-hearing control subjects, peripheral gaze results in inhibition of the auditory cortex, but no detectable response in the medial geniculate body (MGB) and inferior colliculus (IC). In patients with GET, peripheral gaze (1) reduced the cortical inhibition, (2) inhibited the MGB, and (3) activated the IC. Furthermore, increased tinnitus loudness is represented by increased activity in the cochlear nucleus (CN) and IC and reduced inhibition in the auditory cortex (AC). The increase of CN and IC activity with peripheral gaze is consistent with models of plastic reorganization in the brainstem following vestibular schwannoma removal. The activity decrease in the MGB and the reduced inhibition of the AC support a model that attributes tinnitus to a dysrhythmia of the thalamocortical loop, leading to hypometabolic theta activity in the MGB. Our data offer the first support of this loop hypothesis of tinnitus, independent of the initial experiments that led to its formulation.

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Section: Cortical Activity Due To Gazesupporting

confidence: 64%

Section: Cortical Activity Due To Gazementioning

confidence: 97%

The Relation between Perception and Brain Activity in Gaze-Evoked Tinnitus

et al. 2012

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“…We probed laterality of processing using the fact that transfer of information is stronger over contralateral than ipsilateral connections between the cochlea and the cortex (Jäncke, Wüstenberg, Schulze, et al, 2002;Loveless et al, 1994;Suzuki et al, 2002). In general, contrastive context effects on vowel perception were observed.…”

Section: Discussionmentioning

confidence: 99%

“…Monaural input is more strongly transferred to the hemisphere contralaterally to the ear of presentation, for primary and non-primary auditory cortex (Jäncke, Wüstenberg, Schulze, & Heinze, 2002;Loveless, Vasama, Makela, & Hari, 1994;Stefanatos, Joe, Aguirre, Detre, & Wetmore, 2008;Suzuki et al, 2002). Activation levels are two to three times as large in the contralateral as in the ipsilateral hemisphere (Jäncke, Wüstenberg, Schulze, et al, 2002;Suzuki et al, 2002), although with speech stimuli the contralateral dominance effect has been reported to be larger for the right than for the left ear (Stefanatos et al, 2008).…”

Section: Introductionmentioning

confidence: 98%

“…Activation levels are two to three times as large in the contralateral as in the ipsilateral hemisphere (Jäncke, Wüstenberg, Schulze, et al, 2002;Suzuki et al, 2002), although with speech stimuli the contralateral dominance effect has been reported to be larger for the right than for the left ear (Stefanatos et al, 2008). We manipulated dominance of hemispheric processing by presenting stimuli monaurally to the left or the right ear.…”

Section: Introductionmentioning

confidence: 99%

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Hemispheric differences in the effects of context on vowel perception

2012

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a b s t r a c tListeners perceive speech sounds relative to context. Contextual influences might differ over hemispheres if different types of auditory processing are lateralized. Hemispheric differences in contextual influences on vowel perception were investigated by presenting speech targets and both speech and non-speech contexts to listeners' right or left ears (contexts and targets either to the same or to opposite ears). Listeners performed a discrimination task. Vowel perception was influenced by acoustic properties of the context signals. The strength of this influence depended on laterality of target presentation, and on the speech/non-speech status of the context signal. We conclude that contrastive contextual influences on vowel perception are stronger when targets are processed predominately by the right hemisphere. In the left hemisphere, contrastive effects are smaller and largely restricted to speech contexts.

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Stimulus dependence of contralateral dominance in human auditory cortex

Gutschalk

Steinmann

2014

Human Brain Mapping

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The auditory system is often considered to show little contralateral dominance but physiological reports on the contralateral dominance of activity evoked by monaural sound vary widely. Here, we show that part of this variation is stimulus-dependent: blood oxygen level dependent (BOLD) responses to 32 s of monaurally presented unmodulated noise (UN) showed activation in contralateral auditory cortex (AC) and deactivation in ipsilateral AC compared to nonstimulus baseline. Slow amplitude-modulated (AM) noise evoked strong contralateral activation and minimal ipsilateral activation. The contrast of AM-versus-UN was used to separate fMRI activity related to the slow amplitude modulation per se. This difference activation was bilateral although still stronger in contralateral AC. In magnetoencephalography (MEG), the response was dominated by the steady-state activity phase locked to the amplitude modulation. This MEG activity showed no consistent contralateral dominance across listeners. Subcortical BOLD activation was strongly contralateral subsequent to the superior olivary complex (SOC) and showed no significant difference between modulated and UN. An acallosal participant showed similar fMRI activation as the group, ruling transcallosal transmission an unlikely source of ipsilateral enhancement or ipsilateral deactivation. These results suggest that ascending activity subsequent to the SOC is strongly dominant contralateral to the stimulus ear. In contrast, the part of BOLD and MEG activity related to slow amplitude modulation is more bilateral and only observed in AC. Ipsilateral deactivation can potentially bias measures of contralateral BOLD dominance and should be considered in future studies.

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Cortical and subcortical activation with monaural monosyllabic stimulation by functional MRI

Cited by 45 publications

References 19 publications

The Relation between Perception and Brain Activity in Gaze-Evoked Tinnitus

The Relation between Perception and Brain Activity in Gaze-Evoked Tinnitus

Hemispheric differences in the effects of context on vowel perception

Stimulus dependence of contralateral dominance in human auditory cortex

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