Cortical and subcortical anatomy of chronic spatial neglect following vascular damage

Golay, Laetitia; Schnider, Armin; Ptak, Radek

doi:10.1186/1744-9081-4-43

Cited by 66 publications

(53 citation statements)

References 38 publications

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“…4c). These findings are highly consistent with previous studies examining the anatomy of spatial neglect (Vallar and Perani, 1986;Mort et al, 2003;Golay et al, 2008); the lesions of our patients were thus representative of the common lesion sites in spatial neglect.…”

Section: Lesion Comparisonssupporting

confidence: 92%

“…Lesion overlap studies located the critical region responsible for spatial neglect in the inferior parietal cortex (Vallar and Perani, 1986;Mort et al, 2003;Golay et al, 2008), whereas Karnath et al (2004) attributed a similar role to the central sectors of the superior temporal gyrus. In contrast, Doricchi and Tomaiuolo (2003) emphasized the role of frontoparietal disconnection as possible anatomical basis of spatial neglect.…”

Section: Discussionmentioning

confidence: 99%

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The Dorsal Attention Network Mediates Orienting toward Behaviorally Relevant Stimuli in Spatial Neglect

Ptak

Schnider²

2010

J. Neurosci.

121

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Experimental neurophysiology and functional neuroimaging have identified a dorsal attention network that encodes neural signals related to the behavioral significance of a stimulus. The core anatomical areas of this network are the frontal eye fields and the posterior parietal cortex, which are interconnected by the superior longitudinal fasciculus. Here, we show that damage or disconnection of this network predicts the extent to which task-relevant stimuli capture attention of human stroke patients with spatial neglect. Healthy volunteers, right-hemisphere-damaged control participants, and patients with left neglect reacted to peripheral targets defined by their color, which were preceded by a brief distracter stimulus. The position of the distracter and its relevance for the current trial were independently varied. In neglect patients with damage including the frontal eye fields and the superior longitudinal fasciculus, ipsilesional distracters impaired orienting into contralesional space regardless of their relevance for the current task. In contrast, patients with sparing of these regions were only impaired when distracters were task-relevant. These findings indicate that the dorsal attention network controls spatial orienting by modulating the saliency of distracter stimuli according to current action goals.

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Section: Lesion Comparisonssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Dorsal Attention Network Mediates Orienting toward Behaviorally Relevant Stimuli in Spatial Neglect

Ptak

Schnider²

2010

J. Neurosci.

121

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“…Spatial neglect most often results from damage to perisylvian structures of the right hemisphere, including the temporal-parietal junction (Golay et al, 2008;Mort et al, 2003), the superior temporal gyrus (Karnath et al, 2004), and the inferior premotor cortex (Rengachary et al, 2011). In addition, the activity of the right posterior parietal cortex (PPC), as measured with functional MRI, is significantly decreased in patients with acute neglect (Corbetta et al, 2005).…”

Section: Transcranial Magnetic Stimulation and Spatial Attentionmentioning

confidence: 99%

Variability of behavioural responses to transcranial magnetic stimulation: Origins and predictors

2015

Self Cite

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Transcranial magnetic stimulation (TMS) may modulate the excitability of local cortical stimulation sites and distant functionally interconnected regions for minutes, hours or even days. The effects of TMS suggest that it not only acts on activity of the stimulated area, but also on its connections with remote areas. Due to these properties one of the main rationales for the application of TMS in stroke patients is to improve imbalance in interhemispheric inhibition. However, given that TMS may have excitatory or inhibitory effects the impact of stimulation is not easy to predict. In this review, we discuss the different factors that determine the magnitude and quality of physiological and behavioural responses to TMS. Whether TMS is mainly excitatory or inhibitory not only depends on the parameters of stimulation such as pulse frequency and duration, but also on baseline activity of neural tissue before stimulation, or even on cognitive factors such as attention. A major challenge for the application of TMS as therapy method is to identify predictors of positive effects in individual patients. Neuroimaging studies measuring hemodynamic or electrophysiological responses show that changes in interhemispheric competition or adaptations of functional networks in patients with focal brain lesions may predict the individual response to brain stimulation. Such techniques have the potential to select the most appropriate among different intervention methods for an individual patient.

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“…Interestingly, in a previous study, Shapiro et al demonstrated that patients with lesions to the STG and inferior parietal lobe had evidence of a prolonged AB effect compared to those without (Shapiro, et al, 2002). The subtraction analysis that we carried out would suggest that patients with STG damage have an attentional capacity deficit that is not modifiable by behavioural intervention, and we note that damage to this region has previously been associated with prolonged neglect (Golay, Schnider, & Ptak, 2008;Karnath, Rennig, Johannsen, & Rorden, 2011). However, we note that this anatomical subtraction analysis is based on a preliminary result from a post hoc analysis, and as such, requires further examination before any firm conclusions can be drawn.…”

Section: Recovered Versus Ongoing Neglectmentioning

confidence: 48%

The effects of motivational reward on the pathological attentional blink following right hemisphere stroke

Russell²,

Balaji

et al. 2016

Neuropsychologia

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Recent work has shown that attentional deficits following stroke can be modulated by motivational stimulation, particularly anticipated monetary reward. Here we examined the effects of anticipated reward on the pathological attentional blink (AB), an index of temporal selective attention, which is prolonged in patients with right hemisphere damage and a history of left neglect.We specifically compared the effects of reward versus feedback-without-reward on the AB in 17 patients. We found that the patients all manifested impaired performance compared to healthy controls and that reward modulated the pathological blink in the patient group, but only in the second experimental session. When the performance of patients whose neglect had recovered was compared with that of patients who had ongoing or persistent neglect, reward appeared to only influence the AB in the former. These results have implications for our understanding of motivation-attention interactions following right hemisphere stroke, and how they may impact upon recovery from spatial neglect.

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Cortical and subcortical anatomy of chronic spatial neglect following vascular damage

Cited by 66 publications

References 38 publications

The Dorsal Attention Network Mediates Orienting toward Behaviorally Relevant Stimuli in Spatial Neglect

The Dorsal Attention Network Mediates Orienting toward Behaviorally Relevant Stimuli in Spatial Neglect

Variability of behavioural responses to transcranial magnetic stimulation: Origins and predictors

The effects of motivational reward on the pathological attentional blink following right hemisphere stroke

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