Cortical and subcortical vascular hypointensity on T2* weighted imaging in moyamoya disease

Noshiro, Shouhei; Mikami, Takeshi; Komatsu, Katsuya; Miyata, Kei; Akiyama, Yukinori; Wanibuchi, Masahiko; Mikuni, Nobuhiro

doi:10.1080/01616412.2015.1136117

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…The details on imaging parameters for the T2-weighted, FLAIR, T2*weighted, and 3D TOF SPGR sequences at our institute have been mentioned elsewhere. 17,26 The relationship between the HMSF and an extensive ivy sign was evaluated using the ivy sign scoring adapted from a previous report. 24 The region of the anterior cerebral artery (ACA), anterior half of the MCA region (ant-MCA), posterior half of the MCA region (post-MCA), and the region of the posterior cerebral artery (PCA) were involved in this analysis.…”

Section: Mri and Mra Examinationmentioning

confidence: 99%

Pathophysiological consideration of medullary streaks on FLAIR imaging in pediatric moyamoya disease

Suzuki¹,

Mikami²,

Kuribara³

et al. 2017

Journal of Neurosurgery: Pediatrics

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OBJECTIVEMedullary streaks detected on fluid-attenuated inversion recovery (FLAIR) imaging have been considered to be reflected ischemic regions in pediatric moyamoya disease. The purpose of this study was to evaluate these medullary streaks both clinically and radiologically and to discuss associated pathophysiological concerns.METHODSThe authors retrospectively reviewed data from 14 consecutive pediatric patients with moyamoya disease treated between April 2009 and June 2016. Clinical and radiological features and postoperative imaging changes were analyzed. In 4 patients, hyperintense medullary streaks on FLAIR imaging (HMSF) at the level of the centrum semiovale were detected.RESULTSThe HMSF were coincident with hyperintense medullary streaks on a T2-weighted image, though they were not completely coincident with the vasculature on either a T2*-weighted image or contrast-enhanced CT. Analysis revealed significantly higher values in terms of MR angiography scores, number of flow voids of the basal ganglia, and the presence of the medullary artery in the group with HMSF than in those without. In contrast, the presence of white matter damage was significantly less frequent in the HMSF group. All HMSF disappeared after surgery, and the mean apparent diffusion coefficient at the same level was significantly reduced postoperatively.CONCLUSIONSAlthough HMSF should be associated with collateral circulation in moyamoya disease, other factors may be involved, including stagnated cerebrospinal fluid or vasogenic edema that is relevant to the impaired state of the white matter. Findings in this study provide insight into the pathophysiological basis of the perivascular space in moyamoya disease.

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Section: Mri and Mra Examinationmentioning

confidence: 99%

Pathophysiological consideration of medullary streaks on FLAIR imaging in pediatric moyamoya disease

Suzuki¹,

Mikami²,

Kuribara³

et al. 2017

Journal of Neurosurgery: Pediatrics

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“…The inability to maintain a balance with the oxygen demand in the brain causes the deoxyhemoglobin content of the veins to increase, and the venous signal appears to be enhanced SWI. 23 ) Seizure rates were higher in the occlusion model. Therefore, the main factor for this was considered to be cerebral ischemia, as indicated by the multivariate analysis.…”

Section: Discussionmentioning

confidence: 90%

Microbleeds Due to Reperfusion Enhance Early Seizures after Carotid Ligation in a Rat Ischemic Model

Saito

Mikami

Hirano

et al. 2023

Neurol. Med. Chir.(Tokyo)

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Impaired reperfusion in ischemic brain disease is a condition that we are increasingly confronted with owing to recent advances in reperfusion therapy. In the present study, rat models of reperfusion were investigated to determine the causes of acute seizures using magnetic resonance imaging (MRI) and histopathological specimens. Rat models of bilateral common carotid artery ligation followed by reperfusion and complete occlusion were created. We compared the incidence of seizures, mortality within 24 h, MRI, and magnetic resonance spectroscopy (MRS) to evaluate ischemic or hemorrhagic changes and metabolites in the brain parenchyma. In addition, the histopathological specimens were compared with those observed on MRI. In multivariate analysis, the predictive factors of mortality were seizure (odds ratios (OR), 106.572), reperfusion or occlusion (OR, 0.056), and the apparent diffusion coefficient value of the striatum (OR, 0.396). The predictive factors of a convulsive seizure were reperfusion or occlusion (OR, 0.007) and the number of round-shaped hyposignals (RHS) on susceptibility-weighted imaging (SWI) (OR, 2.072). The incidence of convulsive seizures was significantly correlated with the number of RHS in the reperfusion model. RHS on SWI was confirmed pathologically as microbleeds in the extravasation of the brain parenchyma and was distributed around the hippocampus and cingulum bundle. MRS analysis showed that the N-acetyl aspartate level was significantly lower in the reperfusion group than in the occlusion group. In the reperfusion model, RHS on SWI was a risk factor for convulsive seizures. The location of the RHS also influenced the incidence of convulsive seizures.

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Complementary Relation Between Direct and Indirect Bypass in Progress of Collateral Circulation in Moyamoya Disease

et al. 2017

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Cortical and subcortical vascular hypointensity on T2* weighted imaging in moyamoya disease

Abstract: CSVH on T2* WI may be a useful tool for diagnosing and evaluating the extent of moyamoya disease. Our small series study shows that revascularization surgery can decrease the number of CSVH.

Cited by 7 publications

References 27 publications

Pathophysiological consideration of medullary streaks on FLAIR imaging in pediatric moyamoya disease

Pathophysiological consideration of medullary streaks on FLAIR imaging in pediatric moyamoya disease

Microbleeds Due to Reperfusion Enhance Early Seizures after Carotid Ligation in a Rat Ischemic Model

Complementary Relation Between Direct and Indirect Bypass in Progress of Collateral Circulation in Moyamoya Disease

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