Cortical Centres Underlying Auditory Temporal Processing in Humans: A PET Study

Pedersen, C.; Mirz, Frank; Ovesen, Therese; Ishizu, Koji; Johannsen, Peter; Madsen, Stig; Gjedde, Albert

doi:10.3109/00206090009073052

Cited by 23 publications

(17 citation statements)

References 59 publications

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“…Under alcohol induced perceptional changes, a reciprocal inhibitory auditory-visual interaction may provide a successful way to shift the dominant sensorial weight from one modality to the other as a compensatory mechanism. A similar inverse functional correlation in sensory activations could be shown for visual-vestibular stimulations of subjects without pharmacological challenge (Wenzel et al, 1996;Brandt et al, 1998) but was not described for auditory (Benedict et al, 1998;Pedersen et al, 2000, for review see Johnsrude et al, 2002) or visual (Kawashima et al, 1998;Bundesen et al, 2002) attentional processing in pharmacologically unaffected healthy subjects. In this context, the finding of a focal activation of the anterior cingulate during influx vs elimination seems remarkable because the anterior cingulate is considered to have a relevant role for attentional processes in principle and is thought to encode in particular for selective attention ('selection for attention') (Demonet et al, 1993;Benedict et al, 1998).…”

Section: Attentional Performance and Neuronal Activitysupporting

confidence: 56%

Acute Alcohol Effects on Neuronal and Attentional Processing: Striatal Reward System and Inhibitory Sensory Interactions under Acute Ethanol Challenge

Schreckenberger

Amberg

Scheurich

et al. 2004

Neuropsychopharmacol

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The acute influence of ethanol on cerebral activity induces complex psycho-physiological effects that are considerably more pronounced during acute ethanol influx than during maximal blood alcohol concentration (elimination phase). Despite the psychiatric and forensic relevance of these different ethanol effects, the underlying neuronal mechanisms are still unclear. In total, 20 male healthy volunteers were investigated each with three different experimental conditions in a randomized order using an intravenous ethanol challenge (40 g bolus infusion): during influx phase, elimination phase, and under placebo condition. During and after the ethanol (or placebo) infusion, neuropsychological testing of divided attention for visual and auditory stimuli was performed with subsequent 18-FDG PET acquisition. The PET data were analysed using SPM99. Ethanol influx and elimination phase showed focal activations in the bilateral striatum and frontal cortex and deactivations in the occipital cortex. The comparison of influx phase vs elimination phase revealed activations in the anterior cingulate and right prefrontal cortex, relevant deactivations were found in the left superior temporal cortex including Wernicke's area. Neuropsychological testing showed an attentional impairment under ethanol influx compared to ethanol elimination and placebo with an inverse correlation of the attentional performance for auditory stimuli to occipital activity and for visual stimuli to the left temporal (including auditory) cortex. Acute ethanol administration in healthy volunteers stimulates those striatal regions that are considered to have a particular relevance for alcohol craving ('reward system'). Modality specific reciprocal inhibition of sensory cortex activity seems to be relevant for attentional performance during acute alcohol impact.

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Section: Attentional Performance and Neuronal Activitysupporting

confidence: 56%

Acute Alcohol Effects on Neuronal and Attentional Processing: Striatal Reward System and Inhibitory Sensory Interactions under Acute Ethanol Challenge

Schreckenberger

Amberg

Scheurich

et al. 2004

Neuropsychopharmacol

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“…The regions beyond the traditional language areas are important in temporal discrimination of phonemes (Pedersen et al, 2000), and this study shows that tests of temporal processing ability made before an actual cochlear implantation could be of predictive value. Tests of gap detection on the other hand appear not to have suYcient strength to assess temporal processing mechanism in the cortex, nor to demonstrate the integrity of the auditory connections from cochlea to primary auditory cortex.…”

Section: Resultsmentioning

confidence: 97%

“…Thus, although relative specialisation for tonal processing within right auditory regions is seen by functional imaging of a wide variety of perceptual tasks (for review see Zatorre et al, 2002), other studies show a right lateralised response also to duration discrimination of non-linguistic stimuli in the posterior middle temporal cortex as well as in regions responding to a demand for attention and working memory (Binder et al, 1997;Rao et al, 2001;Belin et al, 2002). These areas also emerged in studies of syllable and phoneme discrimination (Pedersen et al, 2000;Binder et al, 2004) and, surprisingly, also in a study of a tactile stimulus (Pardo et al, 1991). The authors oVer no explanation for the right posterior temporal activity observed in a somatosensory vigilance task in which subjects attended to the duration of touch to the great toe.…”

Section: Duration Discriminationmentioning

confidence: 92%

Use of time differences in normal hearing – cortical processing of promontorial stimuli

Mortensen¹,

Madsen²,

Gjedde³

2005

Hearing Research

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“…The researchers found that temporal regularity (and pitch strength) correlated with CBF change in the probable non-PAC bilaterally (lateral, anterior and inferior to the centroids of the PAC in both hemispheres). Other PET studies have explored the processing of auditory information of a fine temporal grain (such as temporal ordering of tones or frequency glide discrimination), but few of these have demonstrated systematic correlates within auditory cortices [Belin et al, 1998;Fiez et al, 1995;Johnsrude et al, 1997;Pedersen et al, 2000]. Belin et al [1998] scanned people while listening to complex speech-like stimuli, composed of a fundamental and four formants.…”

Section: Effect Of Side and Intensity Of Stimulationmentioning

confidence: 99%

Functional Imaging of the Auditory System: The Use of Positron Emission Tomography

Johnsrude¹,

Giraud²,

Frackowiak³

2002

Audiol Neurotol

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Modern brain imaging methods now afford unprecedented opportunities for the in vivo study of central auditory system function. Positron emission tomography (PET) has been used as a functional imaging technique for more than 15 years to study the distribution of cerebral haemodynamic changes associated with auditory stimulation, in subjects with normal and abnormal auditory function. Many of these studies concern processes related to, but not identical with, audition, such as speech perception, melodic processing and directed attention. Additionally, PET has been used to explore auditory perception in clinical populations such as cochlear implantees, neurosurgical candidates and people with tinnitus and auditory hallucinations. The spatial resolution of PET does not appear sufficient to address questions of a fine anatomical grain, e.g. exploring functional specialization within the primary and secondary auditory cortex. Nevertheless, PET has considerable potential as a tool in basic research on, and clinical assessment of, many auditory phenomena. Although functional magnetic resonance imaging can now be used for many studies for which formerly only PET was suitable, PET still possesses unique advantages. For example, it permits acquisition of data from inferior frontal and anterior temporal areas, can be used with subjects with cochlear and other implants (such as pacemakers) and can be used to map neurochemical pathways and receptors.

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Cortical Centres Underlying Auditory Temporal Processing in Humans: A PET Study

Cited by 23 publications

References 59 publications

Acute Alcohol Effects on Neuronal and Attentional Processing: Striatal Reward System and Inhibitory Sensory Interactions under Acute Ethanol Challenge

Acute Alcohol Effects on Neuronal and Attentional Processing: Striatal Reward System and Inhibitory Sensory Interactions under Acute Ethanol Challenge

Use of time differences in normal hearing – cortical processing of promontorial stimuli

Functional Imaging of the Auditory System: The Use of Positron Emission Tomography

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