Cortical Complexity in Anorexia Nervosa: A Fractal Dimension Analysis

Collantoni, Enrico; Madan, Christopher R.; Meneguzzo, Paolo; Chiappini, Iolanna; Tenconi, Elena; Manara, Renzo; Favaro, Angela

doi:10.3390/jcm9030833

Cited by 31 publications

(33 citation statements)

References 42 publications

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“…FD measurement is a sensitive method for describing the atrophy of cortical structures in neurologic and psychiatric conditions [ 44 ]. Studies using voxel-based morphometry (VBM) have found a globally reduced GM volume, but inconsistent results have emerged in identifying regional changes in neurodegenerative disease [ 29 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood

Jao¹,

Lau

Lien

et al. 2021

Brain Sciences

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Normal aging is associated with functional and structural alterations in the human brain. The effects of normal aging and gender on morphological changes in specific regions of the brain are unknown. The fractal dimension (FD) can be a quantitative measure of cerebral folding. In this study, we used 3D-FD analysis with the Desikan–Killiany (DK) atlas to assess subregional morphological changes in adulthood. A total of 258 participants (112 women and 146 men) aged 30–85 years participated in this study. Participants in the middle-age group exhibited a decreased FD in the lateral frontal lobes, which then spread to the temporal and parietal lobes. Men exhibited an earlier and more significant decrease in FD values, mainly in the right frontal and left parietal lobes. Men exhibited more of a decrease in FD values in the subregions on the left than those in the right, whereas women exhibited more of a decrease in the lateral subregions. Older men were at a higher risk of developing mild cognitive impairment (MCI) and exhibited age-related memory decline earlier than women. Our FD analysis using the DK atlas-based prediagnosis may provide a suitable tool for assessing normal aging and neurodegeneration between groups or in individual patients.

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Section: Discussionmentioning

confidence: 99%

Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood

Jao¹,

Lau

Lien

et al. 2021

Brain Sciences

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“…Patients of the Padova site (aka Site 1) were consecutively recruited from the Padova Hospital Eating Disorders Unit. The sample included was the same as in previous studies (Favaro et al, 2013; Collantoni et al, 2020). Patients were recruited if meeting full criteria for AN, as assessed with the Structured Clinical Interview for DSM‐5 (American Psychiatric Association, 2013) by experienced consultants.…”

Section: Methodsmentioning

confidence: 99%

Hippocampal volumes in anorexia nervosa at different stages of the disorder

Collantoni

Tenconi

Solmi

et al. 2020

Euro Eating Disorders Rev

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Introduction Hippocampus is involved in a range of cognitive and behavioural processes, and its volume has been found to be reduced in different psychiatric disorders. The present study aims at exploring hippocampal volumes in anorexia nervosa (AN) at different stages of the disorder (a few months after onset, more than 1 year after onset and after recovery). Methods Two samples were included in the present study. The first was composed of 58 patients (38 with present AN, 20 full recovered from AN) and 38 age‐matched healthy women (HW); the second, recruited at a different site, included 20 patients with AN and 16 HW. Hippocampal volume has been estimated using an automated segmentation algorithm. Age, site of scanning and total intracranial volumes were used as covariates in the statistical analyses. Results AN patients showed a reduced hippocampal volume in comparison to HW, with no substantial differences between patients with recent onset and those with a longer duration of illness. Among patients, hippocampal volumes correlated with body mass index, anxiety and drive for thinness. Discussion Our findings suggest an early role of malnutrition in the morphologic alterations of the hippocampus in AN and a possible role of this brain structure in mediating specific psychopathological traits.

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“…FD has been extensively applied to investigate morphological changes in the cerebral cortex caused by neurological diseases [ 16 , 17 , 18 ]. The procedure of FD computation is as follows.…”

Section: Methodsmentioning

confidence: 99%

“…FD is complementary to volumetric measures and may assist in identifying disease state or disease progression [ 16 ]. Furthermore, FD has been shown to be a promising means for describing the morphology of cortical structures across different neurologic and psychiatric conditions, with good sensitivity in capturing atrophy processes [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Alteration of the Intra- and Inter-Lobe Connectivity of the Brain Structural Network in Normal Aging

Jao¹,

Yeh

Wu³

et al. 2020

Entropy

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The morphological changes in cortical parcellated regions during aging and whether these atrophies may cause brain structural network intra- and inter-lobe connectivity alterations are subjects that have been minimally explored. In this study, a novel fractal dimension-based structural network was proposed to measure atrophy of 68 parcellated cortical regions. Alterations of structural network parameters, including intra- and inter-lobe connectivity, were detected in a middle-aged group (30–45 years old) and an elderly group (50–65 years old). The elderly group exhibited significant lateralized atrophy in the left hemisphere, and most of these fractal dimension atrophied regions were included in the regions of the “last-in, first-out” model. Globally, the elderly group had lower modularity values, smaller component size modules, and fewer bilateral association fibers. They had lower intra-lobe connectivity in the frontal and parietal lobes, but higher intra-lobe connectivity in the temporal and occipital lobes. Both groups exhibited similar inter-lobe connecting pattern. The elderly group revealed separations, sparser long association fibers, commissural fibers, and lateral inter-lobe connectivity lost effect, mainly in the right hemisphere. New wiring and reconfiguring modules may have occurred within the brain structural network to compensate for connectivity, decreasing and preventing functional loss in cerebral intra- and inter-lobe connectivity.

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Cortical Complexity in Anorexia Nervosa: A Fractal Dimension Analysis

Cited by 31 publications

References 42 publications

Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood

Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood

Hippocampal volumes in anorexia nervosa at different stages of the disorder

Alteration of the Intra- and Inter-Lobe Connectivity of the Brain Structural Network in Normal Aging

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