Cortical connective field estimates from resting state fMRI activity

Gravel, Nicolás; Harvey, Ben M.; Nordhjem, Barbara; Haak, Koen V.; Dumoulin, Serge O.; Renken, Remco; Ćurčić‐Blake, Branislava; Cornelissen, Frans W.

doi:10.3389/fnins.2014.00339

Cited by 41 publications

(82 citation statements)

References 55 publications

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“…This deviation of V3 from the neuro-typical condition was further supported by the comparison of the difference of V1-sampling-extent observed for V2 and V3 (Figure 4 B). While it increased from V2 to V3 in controls (t (3) = 3.24, p = 0.04) as reported previously (Gravel et al, 2014;Haak et al, 2013), no increase was evident for albinism (t (5) =1.1, p =0.32). Taken together, these findings indicate a largely unaltered V1-V2 connectivity in albinism, but suggest an alteration of the functional connectivity for V3.…”

Section: Cf-properties In Albinismsupporting

confidence: 83%

Population receptive field and connectivity properties of the early visual cortex in human albinism

Ahmadi

Herbik

Wagner

et al. 2019

Preprint

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In albinism, the pathological decussation of the temporal retinal afferents at the optic chiasm leads to superimposed representations of opposing hemifields in the visual cortex. Here, we assessed the equivalence of the two representations and the cortico-cortical connectivity of the early visual areas.Applying fMRI-based population receptive field (pRF)-mapping (both hemifield and bilateral mapping) and connective field (CF)-modeling, we investigated the early visual cortex in 6 albinotic participants and 4 controls. In albinism, superimposed retinotopic representations of the contra-and ipsilateral visual hemifield were observed on the hemisphere contralateral to the stimulated eye.This was confirmed by the observation of bilateral pRFs during bilateral mapping. Hemifield mapping revealed similar pRF-sizes for both hemifield representations throughout V1 to V3. The typical increase of V1-sampling extent for V3 compared to V2 was not found for the albinotic participants. The similarity of the pRF-sizes for opposing visual hemifield representations highlights the equivalence of the two maps in the early visual cortex. The altered V1-sampling extent in V3 indicates the adaptation of cortico-cortical connections to the abnormal input of the visual cortex. These findings thus suggest that conservative developmental mechanisms are complemented by alterations of the extrastriate cortico-cortical connectivity.

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Section: Cf-properties In Albinismsupporting

confidence: 83%

Population receptive field and connectivity properties of the early visual cortex in human albinism

Ahmadi

Herbik

Wagner

et al. 2019

Preprint

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“…Using a 3-D Gaussian modeling approach with whole-brain resting-state fMRI data, we found that closely connected brain regions exhibit a relatively strong linear topology of their functional connectivity. This linear organization of region to region functional connectivity was highly reliable in early visual regions, following a topographic order along the anterior-posterior axis for eccentricity representation, as predicted by the literature Gravel et al, 2014;Haak et al, 2013).…”

Section: Discussionsupporting

confidence: 68%

“…The connective field mapping technique fits 2 dimensional surface based population receptive fields (pRFs) using cortical signal from one region as the input to another region (Haak et al, 2013). This method has been used to model early visual areas, showing maintenance of retinotpic organization across them (Gravel et al, 2014;Haak et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Linear Input as a Fundamental Motif of Brain Connectivity Organization

O’Rawe

Leung

2019

Preprint

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The pattern of region-to-region functional connectivity has major implications for understanding information transfer and transformation between brain regions. We extended connective field mapping to 3-dimensional anatomical space to derive estimates of cortico-cortical functional organization. For early visual regions we found that the topology of functional connectivity between early visual regions maintained a linear relationship along the anterior-posterior dimension, which is in agreement with the literature. For higher order visual regions (e.g. fusiform face area) our results revealed that their pattern of connectivity, the convergence and biased sampling, seem to contribute to some of their core receptive field properties. Further, we demonstrated that linearity of input is a fundamental aspect of functional connectivity of the whole cortex, with higher linearity between regions within a network than across networks. We found that the principle gradient of linearity resembles decompositions in both traditional functional connectivity and genetic expression reported in previous studies. In sum, the current work provides evidence supporting that linearity of input is likely a fundamental motif of functional connectivity between cortical regions for information processing and transfer, suggesting high linearity may preserve the integrity of information from one region to another within a network. LINEAR INPUT RELATIONSHIPS3

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“…With a color arrow, the functional parcellation obtained in this study is shown as the underlay, while an existing parcellation is shown as the overlay. ;de Zwart et al, 2013;Gravel et al, 2014;Heinzle et al, 2011;Raemaekers et al, 2014;Striem-Amit et al, 2015;Wilf et al, 2017;Yeo et al, 2011). In the whole-brain scale, ICA and seed-based correlation analyses have been shown to reveal similar network patterns (Van Dijk et al, 2010).…”

Section: Ica For Fine-scale Functional Connectivitymentioning

confidence: 99%

“…Since much of the visual cortex has visual-field maps-topographic representations of the polar angle and eccentricity (Wandell et al, 2007), it is reasonable to initially speculate that resting state activity is intrinsically organized by retinotopy. Support for this hypothesis comes in part from the finding that in early visual areas (e.g., V1-V3), correlations in spontaneous activity are generally higher between locations with similar eccentricity representations (Arcaro et al, 2015;Dawson et al, 2016;Genc et al, 2016;Gravel et al, 2014;Heinzle et al, 2011;Jo et al, 2012;Lewis et al, 2016;Striem-Amit et al, 2015;Yeo et al, 2011). However, such eccentricity-dependent functional connectivity has rarely been reported beyond early visual areas (Baldassano et al, 2013;Striem-Amit et al, 2015); it may be relatively weak (Wilf et al, 2017) or observable only after regressing out large-scale activity (Raemaekers et al, 2014), and may also be confounded by the decay of local connectivity over cortical distance (Butt et al, 2013;Dawson et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous activity in the visual cortex is organized by visual streams

Jeong

Wen

et al. 2017

Hum. Brain Mapp.

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Large-scale functional networks have been extensively studied using resting state functional magnetic resonance imaging. However, the pattern, organization, and function of fine-scale network activity remain largely unknown. Here we characterized the spontaneously emerging visual cortical activity by applying independent component analysis to resting state fMRI signals exclusively within the visual cortex. In this sub-system scale, we observed about 50 spatially independent components that were reproducible within and across subjects, and analyzed their spatial patterns and temporal relationships to reveal the intrinsic parcellation and organization of the visual cortex. The resulting visual cortical parcels were aligned with the steepest gradient of cortical myelination, and were organized into functional modules segregated along the dorsal/ventral pathways and foveal/peripheral early visual areas. Cortical distance could partly explain intra-hemispherical functional connectivity, but not inter-hemispherical connectivity; after discounting the effect of anatomical affinity, the fine-scale functional connectivity still preserved similar visual-stream-specific modular organization. Moreover, cortical retinotopy, folding, and cytoarchitecture impose limited constraints to the organization of resting state activity. Given these findings, we conclude that spontaneous activity patterns in the visual cortex are primarily organized by visual streams, likely reflecting feedback network interactions.

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Cortical connective field estimates from resting state fMRI activity

Cited by 41 publications

References 55 publications

Population receptive field and connectivity properties of the early visual cortex in human albinism

Population receptive field and connectivity properties of the early visual cortex in human albinism

Linear Input as a Fundamental Motif of Brain Connectivity Organization

Spontaneous activity in the visual cortex is organized by visual streams

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