Cortical correlates of susceptibility to upper limb freezing in Parkinson’s disease

Scholten, Marlieke; Govindan, Rathinaswamy B.; Braun, Christoph; Bloem, Bastiaan R.; Plewnia, Christian; Krüger, Rejko; Gharabaghi, Alireza; Weiß, Daniel

doi:10.1016/j.clinph.2016.01.028

Cited by 23 publications

(25 citation statements)

References 55 publications

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“…In patients suffering from freezing of gait, enhanced beta band synchronization was reported as a prominent feature both at rest (Toledo et al, 2014), and before and during freezing episodes (Singh et al, 2013; Shine et al, 2014; Scholten et al, 2016; Storzer et al, 2017). Exaggerated beta activity and lack of dynamic modulation of beta are considered to be correlates of upper limb motor impairment in Parkinson’s disease (Androulidakis et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping

et al. 2018

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Gait disturbances in Parkinson's disease are commonly refractory to current treatment options and majorly impair patient's quality of life. Auditory cues facilitate gait and prevent motor blocks. We investigated how neural dynamics in the human subthalamic nucleus of Parkinsons's disease patients (14 male, 2 female) vary during stepping and whether rhythmic auditory cues enhance the observed modulation. Oscillations in the beta band were suppressed after ipsilateral heel strikes, when the contralateral foot had to be raised, and reappeared after contralateral heel strikes, when the contralateral foot rested on the floor. The timing of this 20–30 Hz beta modulation was clearly distinct between the left and right subthalamic nucleus, and was alternating within each stepping cycle. This modulation was similar, whether stepping movements were made while sitting, standing, or during gait, confirming the utility of the stepping in place paradigm. During stepping in place, beta modulation increased with auditory cues that assisted patients in timing their steps more regularly. Our results suggest a link between the degree of power modulation within high beta frequency bands and stepping performance. These findings raise the possibility that alternating deep brain stimulation patterns may be superior to constant stimulation for improving parkinsonian gait.SIGNIFICANCE STATEMENT Gait disturbances in Parkinson's disease majorly reduce patients' quality of life and are often refractory to current treatment options. We investigated how neural activity in the subthalamic nucleus of patients who received deep brain stimulation surgery covaries with the stepping cycle. 20–30 Hz beta activity was modulated relative to each step, alternating between the left and right STN. The stepping performance of patients improved when auditory cues were provided, which went along with enhanced beta modulation. This raises the possibility that alternating stimulation patterns may also enhance beta modulation and may be more beneficial for gait control than continuous stimulation, which needs to be tested in future studies.

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Section: Discussionmentioning

confidence: 99%

Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping

et al. 2018

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“…BMSCs are excellent candidate as they can differentiate into different lineage including neurons and provide opportunity of autologous cell transplantation which limits the risk of graft rejection [2]. The application of cellular scaffold in presence of vital growth factors is essential for efficient long term treatment of neurodegenerative disorders such as Parkinson's disease [10,12,27,50]. However, the main problem with using growth factor encapsulated PLGA microcarriers is the restricted sources of growth factor which will be depleted even with sustain release over long period of time [17].…”

Section: Discussionmentioning

confidence: 99%

Combining NT3-overexpressing MSCs and PLGA microcarriers for brain tissue engineering: A potential tool for treatment of Parkinson's disease

Moradian

Keshvari

Fasehee

et al. 2017

Materials Science and Engineering: C

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Parkinson's disease (PD) is a progressive neurodegenerative disorder that characterized by destruction of substantia nigrostriatal pathway due to the loss of dopaminergic (DA) neurons. Regardless of substantial efforts for treatment of PD in recent years, an effective therapeutic strategy is still missing. In a multidisciplinary approach, bone marrow derived mesenchymal stem cells (BMSCs) are genetically engineered to overexpress neurotrophin-3 (nt-3 gene) that protect central nervous system tissues and stimulates neuronal-like differentiation of BMSCs. Poly(lactic-co-glycolic acid) (PLGA) microcarriers are designed as an injectable scaffold and synthesized via double emulsion method. The surface of PLGA microcarriers are functionalized by collagen as a bioadhesive agent for improved cell attachment. The results demonstrate effective overexpression of NT-3. The expression of tyrosine hydroxylase (TH) in transfected BMSCs reveal that NT-3 promotes the intracellular signaling pathway of DA neuron differentiation. It is also shown that transfected BMSCs are successfully attached to the surface of microcarriers. The presence of dopamine in peripheral media of cell/microcarrier complex reveals that BMSCs are successfully differentiated into dopaminergic neuron. Our approach that sustains presence of growth factor can be suggested as a novel complementary therapeutic strategy for treatment of Parkinson disease.

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“…In experiments in which patients were engaged in cognitive activities while walking, those suffering from FOG typically showed worse walking performance than those without FOG (“dual task interference”), supporting the notion that FOG tends to arise in susceptible individuals when cognitive resources that are needed for maintenance of gait under parkinsonian conditions have to be shared with other activities. Volumetric and fMRI studies have demonstrated that specific frontal and parietal cortical regions are atrophic in patients with FOG, and EEG studies have suggest that patients who suffer from FOG have high beta‐band oscillatory activity in frontal regions EEG, specifically increased during conditions that demand increased attention …”

Section: Parkinsonism As Dysfunction Of the Basal Ganglia Thalamocortmentioning

confidence: 99%

“…Volumetric and fMRI studies have demonstrated that specific frontal and parietal cortical regions are atrophic in patients with FOG, [130][131][132][133][134][135] and EEG studies have suggest that patients who suffer from FOG have high beta-band oscillatory activity in frontal regions EEG, 136 specifically increased during conditions that demand increased attention. 137 Subcortical gait networks, including the striatum, GPi, thalamus, the mesencephalic locomotor region, and the cerebellum, are also involved in FOG. 126,132,133,136,138 Whereas STN-or GPi-DBS reduces FOG in some patients, others suffer from stimulation-induced freezing, 139 potentially depending on the choice of stimulation parameters.…”

Section: Beyond Akinesia and Bradykinesiamentioning

confidence: 99%

Changing views of the pathophysiology of Parkinsonism

Wichmann

2019

Movement Disorders

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Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia) have a long history and primarily model the consequences of dopamine loss in the basal ganglia on the function of the basal ganglia/thalamocortical circuit(s). Changes of firing rates of individual nodes within these circuits were originally considered central to parkinsonism. However, this view has now given way to the belief that changes in firing patterns within the basal ganglia and related nuclei are more important, including the emergence of burst discharges, greater synchrony of firing between neighboring neurons, oscillatory activity patterns, and the excessive coupling of oscillatory activities at different frequencies. Primarily focusing on studies obtained in nonhuman primates and human patients with Parkinson's disease, this review summarizes the current state of this field and highlights several emerging areas of research, including studies of the impact of the heterogeneity of external pallidal neurons on parkinsonism, the importance of extrastriatal dopamine loss, parkinsonism‐associated synaptic and morphologic plasticity, and the potential role(s) of the cerebellum and brainstem in the motor dysfunction of Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society

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Cortical correlates of susceptibility to upper limb freezing in Parkinson’s disease

Cited by 23 publications

References 55 publications

Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping

Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping

Combining NT3-overexpressing MSCs and PLGA microcarriers for brain tissue engineering: A potential tool for treatment of Parkinson's disease

Changing views of the pathophysiology of Parkinsonism

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