Cortical dopamine D2/D3 receptors and verbal memory in man

Relationship of dopamine D1 receptor binding in striatal and extrastriatal regions to cognitive functioning in healthy humans

“…In addition, discrepant findings between studies relating DA binding and cognition are common. For example, whereas Takahashi et al (2008) found a correlation between D2 receptor binding in HC and episodic memory, Lumme et al (2010) found no such relationship for HC or any other brain region. Differences in results across studies may be due to variations in PET imaging methods, sample composition, task selection, or a combination among these factors.…”

Verbal memory and 5-HT1A receptors in healthy volunteers – A PET study with [carbonyl-11C]WAY-100635

“…The respective scores of Immediate and Delayed verbal paired associates, representing verbal learning, were 21 (11-24) and 8 (4-8). A composite verbal memory score was constructed as previously described (Lumme et al, 2010), and had a median of 107 and range of 82-123 in this sample. We found that 5-HT1A receptor binding was positively correlated with measures of verbal memory, such that subject with higher binding tended to perform better than subject with lower binding (Fig.…”

Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults

“…Although we establish a system-level pathway from COMT rs4633 to the FCD in the left inferior parietal lobule then to verbal intelligence in Chinese Han healthy young adults, the exact modulation of gene on brain function remains unclear. Previous studies show that the dopamine acts on dopamine D 2 and D 3 receptors to regulate cognitive functions (Chen et al, 2005 ; Guo et al, 2006 ; Lumme et al, 2010 ). In this study, we find that brain regions with greater lrFCD differences among the three COMT genotypic groups show relatively lower expression of the DRD2 and DRD3 .…”

“…Dopaminergic system plays an important role in human verbal intelligence formation (Previc, 1999 ; Guo et al, 2006 ; Lumme et al, 2010 ). Even though COMT rs4633 is a synonymous variation locating within exon 3 of the MB-COMT transcript and exon 1 of the S-COMT transcript, which do not result in alteration of amino acid sequence, its primary transcriptional mRNA might influence the COMT translation via changing RNA stem-loop structure (Nackley et al, 2006 ).…”

“…To examine the association between the effect of COMT rs4633 on brain FCD and expression patterns of dopamine receptors, we performed sample-wise spatial correlation analysis to identify the relationship between statistical map derived from group difference of FCD and expression patterns of two dopamine receptors that have been previously implicated in verbal intelligence (Guo et al, 2006 ; Lumme et al, 2010 ) by utilizing publicly available gene expression data from six donated brains provided by AHBA (Hawrylycz et al, 2012 ). In brief, we extracted the MNI coordinates of each sample, then averaged values of the statistical map within each spherical ROI ( r = 6 mm) centered at MNI coordinate.…”