Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson’s disease

Melloni, Margherita; Sedeño, Lucas; Hesse, Eugenia; García‐Cordero, Indira; Mikulan, Ezequiel; Plastino, A.; Marcotti, Aida; López, José David; Bustamante, Catalina; Lopera, Francisco; Pineda, David; García, Adolfo M.; Manes, Facundo; Trujillo, Natalia; Ibáñez, Agustín

doi:10.1038/srep11899

Cited by 70 publications

(81 citation statements)

References 59 publications

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“…Other clinical evidence sustaining the causal link between language processing and the motor systems comes from studies on Parkinson’s patients (e.g., Cardona et al, 2014; Melloni et al, 2015) exploiting the so-called action-sentence compatibility effect (ACE, Glenberg and Kaschak, 2002). This effect shows that comprehending a sentence describing an action denoting movements toward or away from the body (e.g., ‘Launch the ball’ or ‘Close the drawer’) facilitates movements in the same direction, but slows down movements in the opposite direction.…”

Section: Discussionmentioning

confidence: 99%

Developmental Coordination Disorder Affects the Processing of Action-Related Verbs

Mirabella

Signore

Lakens

et al. 2017

Front. Hum. Neurosci.

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Processing action-language affects the planning and execution of motor acts, which suggests that the motor system might be involved in action-language understanding. However, this claim is hotly debated. For the first time, we compared the processing of action-verbs in children with Developmental Coordination Disorder (DCD), a disease that specifically affects the motor system, with children with a typical development (TD). We administered two versions of a go/no-go task in which verbs expressing either hand, foot or abstract actions were presented. We found that only when the semantic content of a verb has to be retrieved, TD children showed an increase in reaction times if the verb involved the same effector used to give the response. In contrast, DCD patients did not show any difference between verb categories irrespective of the task. These findings suggest that the pathological functioning of the motor system in individuals with DCD also affects language processing.

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Section: Discussionmentioning

confidence: 99%

Developmental Coordination Disorder Affects the Processing of Action-Related Verbs

Mirabella

Signore

Lakens

et al. 2017

Front. Hum. Neurosci.

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“…These steps are critical and perhaps unavoidable to characterize the organ's functional organization with some degree of external validity. Indeed, thanks to this approach, replicable associations have been established between damage to circumscribed regions and impairments of specific functions, including motor (Zgaljardic et al, 2003), somatosensory (Meyer et al, 2016), socio-cognitive (Gold and Shadlen, 2007; Ibáñez et al, 2010, 2016b; Couto et al, 2013; Baez et al, 2014, 2016b,c; Melloni et al, 2016), interoceptive (Couto et al, 2015; García-Cordero et al, 2016), executive (Rabinovici et al, 2015; Sedeño et al, 2016), linguistic (Ullman, 2008; Cardona et al, 2014; García and Ibáñez, 2014, 2016; Bocanegra et al, 2015; García, 2015; Melloni et al, 2015; García et al, 2016a,b,c; Abrevaya et al, 2017), and pragmatic (Kaplan et al, 1990; Stemmer, 2008) skills.…”

Section: Introductionmentioning

confidence: 99%

A Lesion-Proof Brain? Multidimensional Sensorimotor, Cognitive, and Socio-Affective Preservation Despite Extensive Damage in a Stroke Patient

García

Sedeño

Murcia

et al. 2017

Front. Aging Neurosci.

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In this study, we report an unusual case of mutidimensional sensorimotor, cognitive, and socio-affective preservation in an adult with extensive, acquired bilateral brain damage. At age 43, patient CG sustained a cerebral hemorrhage and a few months later, she suffered a second (ischemic) stroke. As a result, she exhibited extensive damage of the right hemisphere (including frontal, temporal, parietal, and occipital regions), left Sylvian and striatal areas, bilateral portions of the insula and the amygdala, and the splenium. However, against all probability, she was unimpaired across a host of cognitive domains, including executive functions, attention, memory, language, sensory perception (e.g., taste recognition and intensity discrimination), emotional processing (e.g., experiencing of positive and negative emotions), and social cognition skills (prosody recognition, theory of mind, facial emotion recognition, and emotional evaluation). Her functional integrity was further confirmed through neurological examination and contextualized observation of her performance in real-life tasks. In sum, CG's case resists straightforward classifications, as the extent and distribution of her lesions would typically produce pervasive, multidimensional deficits. We discuss the rarity of this patient against the backdrop of other reports of atypical cognitive preservation, expound the limitations of several potential accounts, and highlight the challenges that the case poses for current theories of brain organization and resilience.

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“…(2014) found that the action-sentence compatibility effect (ACE) was abolished in early PD patients, but not in patients with peripheral motor deficits. The lack of an ACE effect in PD has been shown to be due to reduced motor potential, aberrant frontotemporal connectivity, and overall volume of basal ganglia atrophy (Melloni et al, 2015). Action language deficits have also been observed in language production: Bocanegra et al (2015) found disruptions of action verb production in PD patients compared to controls.…”

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confidence: 99%

Impaired Comprehension of Speed Verbs in Parkinson’s Disease

Speed

Dam

Hirath

et al. 2017

J Int Neuropsychol Soc

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Objective: A wealth of studies provide evidence for action simulation during language comprehension. Recent research suggests such action simulations might be sensitive to finegrained information, such as speed. Here we present a crucial test for action simulation of speed in language by assessing speed comprehension in patients with Parkinson's disease (PD). Based on the patients' motor deficits, we hypothesized that the speed of motion described in language would modulate their performance in semantic tasks. Specifically, they would have more difficulty processing language about relatively fast speed than language about slow speed. Method:We conducted a semantic similarity judgment task on fast and slow action verbs in patients with PD and age-matched healthy controls. Participants had to decide which of two verbs most closely matched a target word. Results: Compared to controls, PD patients were slower making judgments about fast action verbs, but not for judgments about slow action verbs, suggesting impairment in processing language about fast action. Moreover, this impairment was specific to verbs describing fast action performed with the hand. Conclusions:Problems moving quickly lead to difficulties comprehending language about moving quickly.This study provides evidence that speed is an important part of action representations.Keywords: embodiment; Parkinson's disease; action semantics; speed Speed -Speed Verbs in Parkinson's Disease 3 The view that meaning in language is represented in modality-specific brain regions (e.g., Binder & Desai, 2011) contrasts with proposals that meaning is stored in abstract, amodal systems (e.g., Landau & Dumais, 1997). There now exist a large number of studies demonstrating action simulation during language comprehension (for review see Fischer & Zwaan, 2008). A critical question, however, is the level of abstraction of action simulations; to what extent do they mirror real-world action? Embodied theories are underspecified in terms of how much information is contained in a simulation (Sanford, 2008), or at what grain information is represented.Action simulations include the specific effector used in the action (Hauk, Johnsrude, & Pulvermüller, 2004), or the specificity of the action . Recent research suggests even fine-grained temporal information is represented in action simulations: whether the action is fast or slow (Speed & Vigliocco, 2014;Speed & Vigliocco, 2015; van Dam, Speed, Lai, Vigliocco, & Desai, in press). Speed & Vigliocco (2014) showed online simulations are sensitive to speed: when listening to sentences describing fast and slow actions (e.g. The lion dashed to the balloon vs. The lion ambled to the balloon) looking time towards a concurrent visual scene was longer for slow actions compared to fast actions. Related, mental simulation is also sensitive to the degree of effort implied in a sentence (e.g., pushing the piano vs. pushing the chair) (Moody & Gennari, 2010).Studies of patients with motor deficits can provide strong tests of causali...

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Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson’s disease

Cited by 70 publications

References 59 publications

Developmental Coordination Disorder Affects the Processing of Action-Related Verbs

Developmental Coordination Disorder Affects the Processing of Action-Related Verbs

A Lesion-Proof Brain? Multidimensional Sensorimotor, Cognitive, and Socio-Affective Preservation Despite Extensive Damage in a Stroke Patient

Impaired Comprehension of Speed Verbs in Parkinson’s Disease

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