Cortical frequency-specific plasticity is independently induced by intracortical circuitry

Kong, Lingzhi; Wang, Shaohui; Liu, Xiuping; Li, Liang; Zeeman, Michael; Yan, Jun

doi:10.1016/j.neulet.2017.12.044

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…In other words, the AI neurons distant from the electrode tip may be activated or modulated by the neural inputs from the AI neurons in the vicinity of the electrode tip. This interpretation is also supported by our recent finding that ES AI induces frequency-specific changes in auditory responses of other AI neurons in a linear scale under thalamic inactivation (Kong et al, 2018). A third explanation may involve intracollicular interactions, including the inhibitory projections from the ICx to ICc, as discussed above.…”

Section: Frequency-dependence Of Es Ai -Evoked Icc Epspssupporting

confidence: 70%

Cortical Stimulation Induces Excitatory Postsynaptic Potentials of Inferior Colliculus Neurons in a Frequency-Specific Manner

Zhang

et al. 2020

Front. Neural Circuits

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Corticofugal modulation of auditory responses in subcortical nuclei has been extensively studied whereas corticofugal synaptic transmission must still be characterized. This study examined postsynaptic potentials of the corticocollicular system, i.e., the projections from the primary auditory cortex (AI) to the central nucleus of the inferior colliculus (ICc) of the midbrain, in anesthetized C57 mice. We used focal electrical stimulation at the microampere level to activate the AI (ES AI) and in vivo whole-cell current-clamp to record the membrane potentials of ICc neurons. Following the whole-cell patch-clamp recording of 88 ICc neurons, 42 ICc neurons showed ES AIevoked changes in the membrane potentials. We found that the ES AI induced inhibitory postsynaptic potentials in 6 out of 42 ICc neurons but only when the stimulus current was 96 µA or higher. In the remaining 36 ICc neurons, excitatory postsynaptic potentials (EPSPs) were induced at a much lower stimulus current. The 36 ICc neurons exhibiting EPSPs were categorized into physiologically matched neurons (n = 12) when the characteristic frequencies of the stimulated AI and recorded ICc neurons were similar (≤1 kHz) and unmatched neurons (n = 24) when they were different (>1 kHz). Compared to unmatched neurons, matched neurons exhibited a significantly lower threshold of evoking noticeable EPSP, greater EPSP amplitude, and shorter EPSP latency. Our data allow us to propose that corticocollicular synaptic transmission is primarily excitatory and that synaptic efficacy is dependent on the relationship of the frequency tunings between AI and ICc neurons.

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Section: Frequency-dependence Of Es Ai -Evoked Icc Epspssupporting

confidence: 70%

Cortical Stimulation Induces Excitatory Postsynaptic Potentials of Inferior Colliculus Neurons in a Frequency-Specific Manner

Zhang

et al. 2020

Front. Neural Circuits

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Plasticity of the adult auditory system based on corticocortical and corticofugal modulations

Suga

2020

Neuroscience & Biobehavioral Reviews

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Cortical frequency-specific plasticity is independently induced by intracortical circuitry

Cited by 2 publications

References 31 publications

Cortical Stimulation Induces Excitatory Postsynaptic Potentials of Inferior Colliculus Neurons in a Frequency-Specific Manner

Cortical Stimulation Induces Excitatory Postsynaptic Potentials of Inferior Colliculus Neurons in a Frequency-Specific Manner

Plasticity of the adult auditory system based on corticocortical and corticofugal modulations

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