Cortical glucose metabolism in Parkinson's disease without dementia

Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease

“…A × 36,000; B × 26,5000: C × 54,5000; D × 48,000; E × 12,500 duced glucose metabolism in AD brains is a well-established phenomenon [2,37]. Although the existence of reduced glucose metabolism in PD is a topic of debate, and contradicting PET results are available [16,35,38], PD with dementia has consistently been shown to be accompanied by reduced cerebral glucose metabolism [35,38,41]. A lower metabolic rate for glucose may be caused by hypoglycemia (resulting from the above-described hypoperfusion) or defective transport through distorted capillary walls.…”

Upregulation of a small vault RNA (svtRNA2-1a) is an early event in Parkinson disease and induces neuronal dysfunction

“…In addition, our observations indicate that svtRNA2-1a overexpression in differentiated SH-SY5Y impairs neuronal metabolism. It is worth noting that idiopathic PD is heralded by decreased glucose metabolism in different brain regions [62][63][64][65] and, therefore, svtRNA2-1a overexpression could contribute to metabolic impairment in PD. diffuse β-amyloid plaques and a few neurofibrillary tangles in the entorhinal cortex were the only abnormality in some cases.…”

Evaluation of body image and self-concept and their correlation with depressive symptoms in Parkinson's disease

“…These subcortical neurotransmitter systems send diffuse projections to the neocortex and chronic deafferentation from these subcortical systems results in diminished cortical metabolic activity, especially in the posterior cerebral regions, which is more pronounced in patients with cognitive impairment. The disconnection of various subcortical regions from the neocortex and the subsequent effect on thalamocortical and corticocortical connections contributes to the development of various cognitive deficits observed in these patients including disorders of the body image 27 .…”