Cortical hypoperfusion in Parkinson's disease assessed using arterial spin labeled perfusion MRI

Fernández‐Seara, María A.; Mengual, Elisa; Vidorreta, Marta; Aznárez-Sanado, Maite; Loayza, Francis R.; Villagra, Federico; Irigoyen, Juan José; Pastor, María A.

doi:10.1016/j.neuroimage.2011.10.033

Cited by 87 publications

(116 citation statements)

References 49 publications

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“…This perfusion deficit is in keeping with both ASL and positron emission tomography (PET) studies in IPD which have found a similar pattern of hypoperfusion and hypometabolism in IPD patients compared to healthy controls with significant correlation between PET and ASL perfusion patterns (Borghammer et al, 2010; Fernandez-Seara et al, 2012; Kamagata et al, 2011; Ma et al, 2010; Melzer et al, 2011). These studies consistently revealed bilateral hypoperfusion in the occipital lobe (including the cuneus) as well as the posterior parietal regions, with variable patterns in the frontal lobe.…”

Section: Discussionsupporting

confidence: 86%

Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease

Al–Bachari

Parkes

Vidyasagar

et al. 2014

NeuroImage: Clinical

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Idiopathic Parkinson's disease (IPD) is the second most common neurodegenerative disease, yet effective disease modifying treatments are still lacking. Neurodegeneration involves multiple interacting pathological pathways. The extent to which neurovascular mechanisms are involved is not well defined in IPD. We aimed to determine whether novel magnetic resonance imaging (MRI) techniques, including arterial spin labelling (ASL) quantification of cerebral perfusion, can reveal altered neurovascular status (NVS) in IPD.Fourteen participants with IPD (mean ± SD age 65.1 ± 5.9 years) and 14 age and cardiovascular risk factor matched control participants (mean ± SD age 64.6 ± 4.2 years) underwent a 3T MRI scan protocol. ASL images were collected before, during and after a 6 minute hypercapnic challenge. FLAIR images were used to determine white matter lesion score. Quantitative images of cerebral blood flow (CBF) and arterial arrival time (AAT) were calculated from the ASL data both at rest and during hypercapnia. Cerebrovascular reactivity (CVR) images were calculated, depicting the change in CBF and AAT relative to the change in end-tidal CO2.A significant (p = 0.005) increase in whole brain averaged baseline AAT was observed in IPD participants (mean ± SD age 1532 ± 138 ms) compared to controls (mean ± SD age 1335 ± 165 ms). Voxel-wise analysis revealed this to be widespread across the brain. However, there were no statistically significant differences in white matter lesion score, CBF, or CVR between patients and controls. Regional CBF, but not AAT, in the IPD group was found to correlate positively with Montreal cognitive assessment (MoCA) scores. These findings provide further evidence of alterations in NVS in IPD.

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Section: Discussionsupporting

confidence: 86%

Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease

Al–Bachari

Parkes

Vidyasagar

et al. 2014

NeuroImage: Clinical

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“…Notably, the regions with short-range FCD reduction were mainly located in the ventral visual pathway involving the inferior and middle occipital gyrus, Brodmann's area 18 and 19, lingual and fusiform gyrus, and inferior temporal gyrus. Our findings are consistent with previous functional imaging studies that reported significant perfusion deficits and hypometabolism in these regions in PD patients [3,4,30]. Previous morphological studies based on structural MRI also documented significant gray matter volume and thickness reduction in these regions [8,31,32], which might be the anatomical substrate underlying the functional deficits in PD patients.…”

Section: Decreased Short-and Long-range Fcds In Pd Patientssupporting

confidence: 92%

“…Extensive neuroimaging studies using positron emission tomography (PET), single photon emission computed tomography (SPECT) and perfusion magnetic resonance imaging (MRI) have reported widespread cortical hypometabolism and hypoperfusion in PD http://dx.doi.org/10.1016/j.bbr.2014.12.007 0166-4328/© 2014 Elsevier B.V. All rights reserved. patients during rest [2][3][4]. Morphometric studies based on structural MRI have also documented significant reductions in gray matter volume [5,6], cortical thickness [6][7][8][9], and cortical gyrification, as well as subcortical volumetric atrophy [8,10,11], in PD patients.…”

Section: Introductionmentioning

confidence: 98%

Abnormal functional connectivity density in Parkinson's disease

Zhang

et al. 2015

Behavioural Brain Research

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“…Bohnen et al 8 also acquired their data in patients with eyes open, and they found prominent primary visual deficits in PD-NC. Using MRI arterial spin labelling in PD-NC with eyes open, Fernández-Seara et al 40 also observed prominent occipital deficits. Conversely, some of the FDG studies with eyes closed6 22 did not find occipital pole reductions in PD.…”

Section: Discussionmentioning

confidence: 97%

Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study

Firbank

Yarnall

Lawson

et al. 2016

J Neurol Neurosurg Psychiatry

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Objective To assess reductions of cerebral glucose metabolism in Parkinson's disease (PD) with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET), and their associations with cognitive decline. Methods FDG-PET was performed on a cohort of 79 patients with newly diagnosed PD (mean disease duration 8 months) and 20 unrelated controls. PD participants were scanned while on their usual dopaminergic medication. Cognitive testing was performed at baseline, and after 18 months using the Cognitive Drug Research (CDR) and Cambridge Neuropsychological Test Automated Battery (CANTAB) computerised batteries, the Mini-Mental State Examination (MMSE), and the Montreal Cognitive Assessment (MoCA). We used statistical parametric mapping (SPM V.12) software to compare groups and investigate voxelwise correlations between FDG metabolism and cognitive score at baseline. Linear regression was used to evaluate how levels of cortical FDG metabolism were predictive of subsequent cognitive decline rated with the MMSE and MoCA. Results PD participants showed reduced glucose metabolism in the occipital and inferior parietal lobes relative to controls. Low performance on memory-based tasks was associated with reduced FDG metabolism in posterior parietal and temporal regions, while attentional performance was associated with more frontal deficits. Baseline parietal to cerebellum FDG metabolism ratios predicted MMSE (β=0.38, p=0.001) and MoCA (β=0.3, p=0.002) at 18 months controlling for baseline score. Conclusions Reductions in cortical FDG metabolism were present in newly diagnosed PD, and correlated with performance on neuropsychological tests. A reduced baseline parietal metabolism is associated with risk of cognitive decline and may represent a potential biomarker for this state and the development of PD dementia.

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Cortical hypoperfusion in Parkinson's disease assessed using arterial spin labeled perfusion MRI

Cited by 87 publications

References 49 publications

Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease

Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease

Abnormal functional connectivity density in Parkinson's disease

Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study

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