Cortical inhibition and primitive reflexes in remitted first-episode mania

Mehta, Urvakhsh Meherwan; Sanjay, Tarasingh N; Venkatasubramanian, Ganesan; Muralidharan, Kesavan

doi:10.1016/j.brs.2019.05.004

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…In this report, we explore the association between the manic symptom severity (a surrogate for behavioral disinhibition) and cortical inhibition in individuals with drug naïve/drug-free (off treatment for > 2 months before the experiment) manic/hypomanic states. Based on our earlier observations [4], we hypothesized that longer CSP will be associated with milder manic symptoms.…”

Section: Sirmentioning

confidence: 98%

“…Specifically, in vivo functioning of the gamma aminobutyric acid (GABA) interneurons can be examined using cortical silent period (CSP; GABA B subreceptor system), short (SICI; GABA A sub-receptor system) and long (LICI; GABA B sub-receptor system) interval intracortical inhibition paradigms [2,3]. CSP, a transient isoelectric cortical state in response to a suprathreshold TMS pulse has been described as a neuromarker of frontal released reflexes, and, as an extension thereof, of behavioral disinhibition [4]. A longer motor CSP indicates better frontal GABA B inhibitory tone.…”

Section: Sirmentioning

confidence: 99%

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Shorter cortical silent period is associated with manic symptom severity

2021

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Section: Sirmentioning

confidence: 98%

Section: Sirmentioning

confidence: 99%

Shorter cortical silent period is associated with manic symptom severity

2021

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The Efficacy of the Sensorimotor Training Program on Sensorimotor Development, Auditory and Visual Skills of Schoolchildren Aged 5–8 Years

Stephens-Sarlós,

Stephens,

Szabo

2024

Child Youth Care Forum

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Background Around 800 million young children worldwide have cognitive-developmental limitations due to issues related to biological, environmental, and psychosocial factors. These problems lead to educational challenges, limited skill development, and higher unemployment rates. Therefore, timely interventions addressing the underlying problems in institutional settings are critically important. Objective The authors created the “Sensorimotor Training Program” (STP) as a critical intervention to develop skills essential for starting school. This experimental study aimed to investigate the impact of the STP in an institutional setting, targeting the specific auditory and visual skills crucial for kindergarten and primary school learning. Methods The STP comprises 120 training sessions focused on sensorimotor maturation. Seven hundred and seventy-two children aged 5–8 participated in the study, with 704 in the experimental and 68 in the control group, each containing a relatively balanced ratio of boys to girls. The study spanned six to eight months, with three to five weekly sessions. Results The intervention resulted in significant improvements in sensorimotor development in the experimental compared to the control group [p < .001, effect size (d) = .483; auditory skills r = .605 p < .001, d = .366; visual skills r = .542, p < .001, d = .294]. The intervention group also improved compared to its baseline measurements. Conclusion These results show that implementing the STP in school settings can improve sensorimotor development, impacting auditory and visual skills in children aged 5–8. These intervention-based improvements are above and beyond biological maturation.

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