Cortical Map Reorganization Enabled by Nucleus Basalis Activity

Kilgard, Michael P.; Merzenich, Michael M.

doi:10.1126/science.279.5357.1714

Cited by 1,120 publications

(849 citation statements)

References 35 publications

Supporting

Mentioning

808

Contrasting

Unclassified

Order By: Relevance

“…Rats were repeatedly presented with a midfrequency pure tone over the course of 20 days either with or without paired VNS, followed by auditory mapping to derive the frequency map in primary auditory cortex. Consistent with previous studies, repeated presentation of tones without VNS did not induce map reorganization [33]. However, presentation of the same number of tones paired with VNS significantly increased the proportion of neurons that responded to frequencies near the paired tone.…”

Section: Enhancing Plasticity With Vns Vns Paired With Tones Drives Rsupporting

confidence: 90%

“…VNS drives activity in the cholinergic basal forebrain, providing a potential pathway to enhance plasticity [15,33]. Our recent study directly tested whether the nucleus basalis (NB), a primary component of the cholinergic basal forebrain, is required for VNS-dependent enhancement of map plasticity in motor cortex.…”

Section: Vns Paired With Forelimb Training Enhances Reorganization Ofmentioning

confidence: 99%

See 1 more Smart Citation

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Hays

2016

Neurotherapeutics

View full text Add to dashboard Cite

Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one such potential targeted plasticity therapy. Vagus nerve stimulation (VNS) drives activation of neuromodulatory nuclei that are associated with plasticity, including the cholinergic basal forebrain and the noradrenergic locus coeruleus. Repeatedly pairing brief bursts of VNS sensory or motor events drives robust, event-specific plasticity in neural circuits. Animal models of chronic tinnitus, ischemic stroke, intracerebral hemorrhage, traumatic brain injury, and post-traumatic stress disorder benefit from delivery of VNS paired with successful trials during rehabilitative training. Moreover, mounting evidence from pilot clinical trials provides an initial indication that VNS-based targeted plasticity therapies may be effective in patients with neurological diseases and injuries. Here, I provide a discussion of the current uses and potential future applications of VNS-based targeted plasticity therapies in animal models and patients, and outline challenges for clinical implementation.

show abstract

Section: Enhancing Plasticity With Vns Vns Paired With Tones Drives Rsupporting

confidence: 90%

Section: Vns Paired With Forelimb Training Enhances Reorganization Ofmentioning

confidence: 99%

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Hays

2016

Neurotherapeutics

View full text Add to dashboard Cite

show abstract

“…Experimental results (Singer and Rauschecker, 1982;Kilgard and Merzenich, 1998) and modeling work (Hasselmo, 1993;Sánchez-Montañés et al, 2000) have shown that cholinergic modulation is an essential ingredient in cortical plasticity. The model predicts how strong ACh release, such as during repeated mismatches, or as a consequence of an environmental stressor, can influence the sharpness of the neural code, by altering the degree of match required for bottom-up and top-down matches to prevent reset.…”

Section: Discussionmentioning

confidence: 99%

Spikes, synchrony, and attentive learning by laminar thalamocortical circuits

2008

View full text Add to dashboard Cite

“…Detailed descriptions of experimental preparation and microelectrode mapping techniques can be found in previous publications (Kilgard and Merzenich, 1998a, 1998bKilgard et al, 2001a,b) and are described in brief below.…”

Section: Methodsmentioning

confidence: 99%

Asynchronous inputs alter excitability, spike timing, and topography in primary auditory cortex

Pandya¹,

Moucha²,

Engineer³

et al. 2005

Hearing Research

Self Cite

View full text Add to dashboard Cite

Correlation-based synaptic plasticity provides a potential cellular mechanism for learning and memory. Studies in the visual and somatosensory systems have shown that behavioral and surgical manipulation of sensory inputs leads to changes in cortical organization that are consistent with the operation of these learning rules. In this study, we examine how the organization of primary auditory cortex (A1) is altered by tones designed to decrease the average input correlation across the frequency map. After one month of separately pairing nucleus basalis stimulation with 2 and 14 kHz tones, a greater proportion of A1 neurons responded to frequencies below 2 kHz and above 14 kHz. Despite the expanded representation of these tones, cortical excitability was specifically reduced in the high and low frequency regions of A1, as evidenced by increased neural thresholds and decreased response strength. In contrast, in the frequency region between the two paired tones, driven rates were unaffected and spontaneous firing rate was increased. Neural response latencies were increased across the frequency map when nucleus basalis stimulation was associated with asynchronous activation of the high and low frequency regions of A1. This set of changes did not occur when pulsed noise bursts were paired with nucleus basalis stimulation. These results are consistent with earlier observations that sensory input statistics can shape cortical map organization and spike timing.

show abstract

Cortical Map Reorganization Enabled by Nucleus Basalis Activity

Cited by 1,120 publications

References 35 publications

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Spikes, synchrony, and attentive learning by laminar thalamocortical circuits

Asynchronous inputs alter excitability, spike timing, and topography in primary auditory cortex

Contact Info

Product

Resources

About