Cortical modulation of nociception by galvanic vestibular stimulation: A potential clinical tool?

Hagiwara, Koichi; Perchet, Caroline; Frot, Maud; Bastuji, Hélène; Garcia-Larrea, Luis

doi:10.1016/j.brs.2019.10.009

Cited by 15 publications

(10 citation statements)

References 92 publications

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“…Hence, participants' behavior towards others' pain is not a sign of disengagement, but rather a willingness to prevent suffering at a personal cost. Previous studies have uncovered similar otherregarding costly choice behavior in relation to pain ([15]; [23]), as well as a positive influence of uncertainty for others' wellbeing in individual pro-sociality ( [29]). Our data support, and extend these previous findings, by revealing that costly prosocial behavior encompasses different kinds of targets (partner vs. stranger) and exceeds the price participants are willing to pay for their own pain management.…”

Section: Decisions For Others' Pain Are Less Riskymentioning

confidence: 91%

“…Participants rated the pulse received on a visual analog scale, ranging from 0 (corresponding to "no pain") to 10, where 1 was explicitly cast as the lowest pain experienced. Although slightly different from previous studies employing similar laser stimulations (where the pain threshold is mapped to around ~4 of the 10point scale, (Hagiwara et al, 2020), our approach allowed us to exploit the full scale to identify three energy levels characterized by different, and well distinguishable, pain levels. The average ratings (among the three repetitions) of all possible energy levels was used to identify three stimulations corresponding approximately to scale values of 3, 5 and 7 (low, medium and high pain).…”

Section: Pain Stimulationsmentioning

confidence: 98%

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The Effect of Uncertainty on Pain Decisions for Self and Others

Loued-Khenissi¹,

Martin²,

Schumacher³

et al. 2022

Preprint

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Estimating others’ pain is a challenging inferential process, associated with a high degree of uncertainty. The present study exploited models of probabilistic decision-making to investigate how uncertainty influences the assessment of another’s pain. We engaged sixty-three dyads (43 strangers and 20 romantic couples) in a task where individual choices affected the pain delivered to either oneself (the agent) or the other member of the dyad. At each trial, agents were presented with cues predicting a given pain intensity with an associated probability of occurrences. Agents chose either a sure (mild decrease of pain) or risky (50% chance of avoiding pain altogether) management option, following which they were asked to bid on their choice. A heat stimulation was then issued to the target (self or other), whose intensity was rated. We found that, the higher the expected pain, the more risk-averse agents became, in line with findings in value-based decision-making. Furthermore, agents gambled less on another individual’s pain (especially strangers) and placed higher bids on pain relief than they did for themselves. Most critically, the uncertainty associated with expected pain dampened ratings made for strangers’ pain. This contrasted with the effect on an agent’s own pain, for which risk had a marginal hyperalgesic effect. Overall, our results suggested that risk selectively affects decision-making on a stranger’s suffering, both at the level of assessment and treatment selection, by 1) leading to underestimation, 2) privileging sure options, and 3) altruistically allocating more money to insure the treatment’s success.

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Section: Decisions For Others' Pain Are Less Riskymentioning

confidence: 91%

Section: Pain Stimulationsmentioning

confidence: 98%

The Effect of Uncertainty on Pain Decisions for Self and Others

Loued-Khenissi¹,

Martin²,

Schumacher³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The scale used to assess pain intensity differed slightly from established specifications in the literature [18]. First, participants were instructed to map first pain experiences at ~1 on a 0-10 scale, whereas previous studies do so at ~4 (e.g., [24]). Furthermore, in the main experiment we employed a scale anchored by emojis (see also [17]).…”

Section: Limitations Of the Study And Conclusionmentioning

confidence: 99%

The effect of uncertainty on pain decisions for self and others

Loued-Khenissi

Martin‐Brevet

Schumacher

et al. 2022

European Journal of Pain

View full text Add to dashboard Cite

Estimating others' pain is a challenging inferential process, associated with a high degree of uncertainty. The present study exploited models of probabilistic decision-making to investigate how uncertainty influences the assessment of another's pain. We engaged sixty-three dyads (43 strangers and 20 romantic couples) in a task where individual choices affected the pain delivered to either oneself (the agent) or the other member of the dyad. At each trial, agents were presented with cues predicting a given pain intensity with an associated probability of occurrences. Agents chose either a sure (mild decrease of pain) or risky (50% chance of avoiding pain altogether) management option, following which they were asked to bid on their choice. A heat stimulation was then issued to the target (self or other), whose intensity was rated. We found that, the higher the expected pain, the more risk-averse agents became, in line with findings in value-based decision-making. Furthermore, agents gambled less on another individual's pain (especially strangers) and placed higher bids on pain relief than they did for themselves. Most critically, the uncertainty associated with expected pain dampened ratings made for strangers' pain. This contrasted with the effect on an agent's own pain, for which risk had a marginal hyperalgesic effect.Overall, our results suggested that risk selectively affects decision-making on a stranger's suffering, both at the level of assessment and treatment selection, by 1) leading to underestimation, 2) privileging sure options, and 3) altruistically allocating more money to insure the treatment's success.Perspective: How does uncertainty affect other-regarding decision-making on pain? Using a formal account of uncertainty in a probabilistic pain task, we find individuals globally show prosocial tendencies when deciding on others' pain, yet downgrade ratings on strangers' pain when the latter is endowed with higher predicted uncertainty.

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“…Persistent pain is a major healthcare problem worldwide, costing billions of dollars each year and being commonly refractory to existing treatments [for citations, see 1]. We read with interest the recent research article by Hagiwara et al [2] in your journal, in which it was reported that active, but not sham, galvanic vestibular stimulation (GVS), significantly modulated experimental pain in 16 healthy volunteers. GVS stimulates the vestibular system via direct current applied to bilateral mastoids, inducing activation in various vestibular, cognitive, affective and pain-related brain regions.…”

mentioning

confidence: 99%

“…Hagiwara et al [2] note that some post-stroke pain patients [3] found the administration of CVS to be intolerable, even if the technique induced pain relief. They reported that GVS, on the other hand, was well tolerated by their healthy subjects, thus proposing that if GVS also reduces pain in persistent (chronic) pain patients, it would be a tolerable therapeutic option when CVS is not tolerated.…”

mentioning

confidence: 99%