Cortical Networks Subserving the Perception of Tinnitus - a PET Study

Mirz, Frank; Gjedde, Albert; Ishizu, Koji; Pedersen, C.

doi:10.1080/000164800454503

Cited by 179 publications

(139 citation statements)

References 8 publications

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“…It was postulated that not only simple auditory processing, but also specific higher order cognitive elaboration may be involved in tinnitus perception. Disabling and distressing tinnitus may be associated with activity in functionally linked cortical areas that are predominantly right-hemispheric, subserving the processing of auditory signals, memory and attention [1,16,[45][46][47]. This would also account for the discrepancy between the severe adverse effect on patients' lives compared to the acoustically relatively weak tinnitus sound (>85% does not exceed 10 dB).…”

Section: Discussionmentioning

confidence: 99%

“…This abnormal neuronal activity is hypothesized to be the neural correlate of tinnitus, which is considered to be an auditory phantom phenomenon, similar to central neuropathic pain, due to neural plasticity in response to total or partial deafferentation somewhere along the auditory tract [7,[10][11][12]. Animal and human studies have provided some evidence for this theory [5,9,10,[13][14][15][16][17][18][19]. Functional MRI has been applied in a few studies, mainly case studies [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus

et al. 2007

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Introduction Tinnitus is hypothesized to be an auditory phantom phenomenon resulting from spontaneous neuronal activity somewhere along the auditory pathway. We performed fMRI of the entire auditory pathway, including the inferior colliculus (IC), the medial geniculate body (MGB) and the auditory cortex (AC), in 42 patients with tinnitus and 10 healthy volunteers to assess lateralization of fMRI activation. Methods Subjects were scanned on a 3T MRI scanner. A T2*-weighted EPI silent gap sequence was used during the stimulation paradigm, which consisted of a blocked design of 12 epochs in which music presented binaurally through headphones, which was switched on and off for periods of 50 s. Using SPM2 software, single subject and group statistical parametric maps were calculated. Lateralization of activation was assessed qualitatively and quantitatively. Results Tinnitus was lateralized in 35 patients (83%, 13 right-sided and 22 left-sided). Significant signal change (P corrected <0.05) was found bilaterally in the primary and secondary AC, the IC and the MGB. Signal change was symmetrical in patients with bilateral tinnitus. In patients with lateralized tinnitus, fMRI activation was lateralized towards the side of perceived tinnitus in the primary AC and IC in patients with right-sided tinnitus, and in the MGB in patients with left-sided tinnitus. In healthy volunteers, activation in the primary AC was left-lateralized. Conclusion Our paradigm adequately visualized the auditory pathways in tinnitus patients. In lateralized tinnitus fMRI activation was also lateralized, supporting the hypothesis that tinnitus is an auditory phantom phenomenon.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus

et al. 2007

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“…Using PET, Mirz et al (2000b) reported that both noise masking and administration of lidocaine reduced activity in left amygdala and right prefrontal cortex. For the masking group, activity also reduced in the right anterior cingulate gyrus.…”

Section: Neuro-modulatory Influencesmentioning

confidence: 99%

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

2009

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In this review, we highlight the contribution of advances in human neuroimaging to the current understanding of central mechanisms underpinning tinnitus and explain how interpretations of neuroimaging data have been guided by animal models. The primary motivation for studying the neural subtrates of tinnitus in humans has been to demonstrate objectively its representation in the central auditory system and to develop a better understanding of its diverse pathophysiology and of the functional interplay between sensory, cognitive and affective systems. The ultimate goal of neuroimaging is to identify subtypes of tinnitus in order to better inform treatment strategies. The three neural mechanisms considered in this review may provide a basis for TI classification. While human neuroimaging evidence strongly implicates the central auditory system and emotional centres in TI, evidence for the precise contribution from the three mechanisms is unclear because the data are somewhat inconsistent. We consider a number of methodological issues limiting the field of human neuroimaging and recommend approaches to overcome potential inconsistency in results arising from poorly matched participants, lack of appropriate controls and low statistical power. AbstractIn this review, we highlight the contribution of advances in human neuroimaging to the current understanding of central mechanisms underpinning tinnitus and explain how interpretations of neuroimaging data have been guided by animal models. The primary motivation for studying the neural subtrates of tinnitus in humans has been to demonstrate objectively its representation in the central auditory system and to develop a better understanding of its diverse pathophysiology and of the functional interplay between sensory, cognitive and affective systems. The ultimate goal of neuroimaging is to identify subtypes of tinnitus in order to better inform treatment strategies. The three neural mechanisms considered in this review may provide a basis for TI classification. While human neuroimaging evidence strongly implicates the central auditory system and emotional centres in TI, evidence for the precise contribution from the three mechanisms is unclear because the data are somewhat inconsistent. We consider a number of methodological issues limiting the field of human neuroimaging and recommend approaches to overcome potential inconsistency in results arising from poorly matched participants, lack of appropriate controls and low statistical power.

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“…Furthermore, tinnitus annoyance and its consecutive distress is dependent on patient's emotional and attentional state [Newman et al, 1997]. Chronic tinnitus has been associated with excessive spontaneous activity in the auditory cortex as shown by electrophysiological studies [Kaltenbach et al, 2000] and with changes of cerebral blood flow or increased metabolic activation in the temporal cortex [Arnold et al, 1996;Lockwood et al, 1999;Mirz et al, 2000;Eichhammer et al, 2003]. Further evidence of central involvement was obtained by magnetoencephalography demonstrating that chronic tinnitus patients showed a shift in the cortical frequency map coinciding with the tinnitus frequency and that this shift correlated directly with the tinnitus severity [Muhlnickel et al, 1998].…”

Section: Introductionmentioning

confidence: 99%

Cortical Activation during a Pitch Discrimination Task in Tinnitus Patients and Controls – An fMRI Study

Wunderlich

Schönfeldt‐Lecuona²,

Wolf³

et al. 2009

Audiol Neurotol

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Chronic subjective tinnitus has been associated with aberrant activation of cortical areas involved in the perception of auditory information. This leads to the hypothesis that neural correlates of altered auditory perception may be found in tinnitus patients using functional magnetic resonance imaging. To study brain activation patterns due to acoustic stimulation in a pitch discrimination task, 6 tinnitus patients and 6 age-matched controls were investigated. Tones were presented binaurally at 5 beeps/s with three different frequencies in a block design. Using Statistical Parametrical Mapping, we found activation of secondary auditory areas in both groups. Furthermore, controls showed activation of the right-hemispheric anterior insula, whereas the middle frontal gyrus, putamen and left-hemispheric insula were activated in tinnitus patients. In the between-group analysis, activation of the caudate nucleus, superior frontal gyrus (Brodmann area 8) and cingular cortex was more pronounced in patients than in controls suggesting the perception of auditory inputs in a more emotional context in our patient group compared to controls.

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Cortical Networks Subserving the Perception of Tinnitus - a PET Study

Cited by 179 publications

References 8 publications

Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus

Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

Cortical Activation during a Pitch Discrimination Task in Tinnitus Patients and Controls – An fMRI Study

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