Cortical neuron sensitivity to neurotransmitters following neonatal noradrenaline depletion

Mirmiran, M.; Dijcks, Fred A.; Bos, N. P. A.; Gorter, Jan A.; Werf, D. van der

doi:10.1016/0736-5748(90)90014-s

Cited by 12 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A proportional reduction of tissue protein was also found in the affected brain areas [33]. Neurotransmitter circuitry was also modified: in the cerebral cortex, the level of the gamma-aminobutyric-acidergic (GABAergic) depression of the glutamate-induced single cortical neurons responses was greater in the neonatally REM sleep-deprived rats as compared to controls [35,36], while there was a hyper-sensitivity of the pyramidal cells to noradrenalin in the hippocampus [37].…”

Section: Rem Sleepmentioning

confidence: 83%

A role for sleep in brain plasticity

Dang‐Vu

Desseilles²,

Peigneux

et al. 2006

Pediatric Rehabilitation

112

View full text Add to dashboard Cite

The idea that sleep might be involved in brain plasticity has been investigated for many years through a large number of animal and human studies, but evidence remains fragmentary. Large amounts of sleep in early life suggest that sleep may play a role in brain maturation. In particular, the influence of sleep in developing the visual system has been highlighted. The current data suggest that both Rapid Eye Movement (REM) and non-REM sleep states would be important for brain development. Such findings stress the need for optimal paediatric sleep management. In the adult brain, the role of sleep in learning and memory is emphasized by studies at behavioural, systems, cellular and molecular levels. First, sleep amounts are reported to increase following a learning task and sleep deprivation impairs task acquisition and consolidation. At the systems level, neurophysiological studies suggest possible mechanisms for the consolidation of memory traces. These imply both thalamocortical and hippocampo-neocortical networks. Similarly, neuroimaging techniques demonstrated the experiencedependent changes in cerebral activity during sleep. Finally, recent works show the modulation during sleep of cerebral protein synthesis and expression of genes involved in neuronal plasticity.Keywords: Sleep, plasticity, brain development, memory, functional neuroimaging La idea de que dormir pudiera estar involucrado en la plasticidad cerebral ha sido investigada por muchos añ os a través de un gran nú mero de estudios en animales y humanos, pero la evidencia permanece fragmentada. Grandes cantidades de sueñ o en los inicios de la vida sugiere que el sueñ o puede tener un papel en la maduració n cerebral. En particular ha sido remarcada la influencia del sueñ o en el desarrollo del sistema visual. Los datos actuales sugieren que las etapas de sueñ o REM y no-REM podrían ser importantes para el desarrollo cerebral. Tales hallazgos demandan la necesidad de un manejo ó ptimo del sueñ o pediátrico. En el cerebro adulto, el papel del sueñ o en el aprendizaje y la memoria es enfatizado por estudios a niveles conductual, sistémico, celular y molecular. Primero, se reporta que las cantidades de sueñ o aumentan después de una tarea de aprendizaje y la falta del sueñ o limita la adquisició n y consolidació n de la tarea. A nivel sistémico, los estudios neurofisioló gicos sugieren posibles mecanismos para la consolidació n de los rastros de memoria. Esto implica a las redes tálamo-cortical y la hipocampo-neocortical. De igual manera, las técnicas de neuroimagen demostraron los cambios dependientes de la experiencia, en la actividad cerebral durante el sueñ o. Finalmente, trabajos recientes muestran durante el sueñ o la modulació n de la síntesis proteica cerebral y la expresió n de los genes involucrados en la plasticidad neuronal.

show abstract

Section: Rem Sleepmentioning

confidence: 83%

A role for sleep in brain plasticity

Dang‐Vu

Desseilles²,

Peigneux

et al. 2006

Pediatric Rehabilitation

112

View full text Add to dashboard Cite

show abstract

“…We have pursued these structural changes at the functional level and found, in adulthood, changes in the neurotransmitter circuitry of neonatally REM deprived animals. In the cerebral cortex the magnitude of the GABAergic depression of the glutamate induced single cortical neurons responses was greater in the neonatally REM deprived rats [59,60]. In the hippocampus there was a supersensitivity of the pyramidal cells to noradrenaline [61].…”

Section: Rem Sleep and Brain Developmentmentioning

confidence: 95%

Development of fetal and neonatal sleep and circadian rhythms

Mirmiran

Maas

Ariagno

2003

Sleep Medicine Reviews

340

273

View full text Add to dashboard Cite

“…Like serotonin, noradrenergic axons make contact with the Cajal Retzius cells in the marginal zone, suggesting a role in the laminar formation of cortical regions [ 132 , 142 , 143 ]. In addition, noradrenalin seems to have an effect on the development of dopaminergic projections in the PFC by providing a dopamine reuptake mechanism through the noradrenalin transporter [ 144 , 145 ] as well as on GABAergic signaling in the PFC [ 146 , 147 ]. Recent studies of rat and primate PFC showed that the α2-adrenoceptor and muscarinic M1 receptor modulate working memory via KCNQ potassium channel [ 148 – 151 ].…”

Section: The Early Stages Of Pfc Developmentmentioning

confidence: 99%

Development of prefrontal cortex

Kolk

Rakić

2021

Neuropsychopharmacol.

184

View full text Add to dashboard Cite

During evolution, the cerebral cortex advances by increasing in surface and the introduction of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be the substrate of highest cognitive functions. Although neurons of the PFC are generated before birth, the differentiation of its neurons and development of synaptic connections in humans extend to the 3rd decade of life. During this period, synapses as well as neurotransmitter systems including their receptors and transporters, are initially overproduced followed by selective elimination. Advanced methods applied to human and animal models, enable investigation of the cellular mechanisms and role of specific genes, non-coding regulatory elements and signaling molecules in control of prefrontal neuronal production and phenotypic fate, as well as neuronal migration to establish layering of the PFC. Likewise, various genetic approaches in combination with functional assays and immunohistochemical and imaging methods reveal roles of neurotransmitter systems during maturation of the PFC. Disruption, or even a slight slowing of the rate of neuronal production, migration and synaptogenesis by genetic or environmental factors, can induce gross as well as subtle changes that eventually can lead to cognitive impairment. An understanding of the development and evolution of the PFC provide insight into the pathogenesis and treatment of congenital neuropsychiatric diseases as well as idiopathic developmental disorders that cause intellectual disabilities.

show abstract

Cortical neuron sensitivity to neurotransmitters following neonatal noradrenaline depletion

Cited by 12 publications

References 19 publications

A role for sleep in brain plasticity

A role for sleep in brain plasticity

Development of fetal and neonatal sleep and circadian rhythms

Development of prefrontal cortex

Contact Info

Product

Resources

About