Cortical Plasticity in the Setting of Brain Tumors

Fisicaro, Ryan A.; Jost, Ethan; Shaw, Katharina S.; Brennan, Nicole Petrovich; Peck, Kyung K.; Holodny, Andrei I.

doi:10.1097/rmr.0000000000000077

Cited by 42 publications

(29 citation statements)

References 32 publications

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“…Neuroplasticity is the ability of the brain to reorganize itself during normal development and in response to illness; it has been extensively reported in normal adult humans, ischemic stroke patients, and brain injury patients (Kong et al, 2016). In glioma patients, increasing studies have demonstrated that both ipsilateral and contralateral brain regions are recruited to compensate for the neurological dysfunction caused by glioma-induced injury Krieg et al, 2013;Auriat et al, 2015;Fisicaro et al, 2016). To date, no study has detected whether the structural and functional plasticity of contralesional MTL in patients with unilateral MTL glioma exist.…”

Section: Discussionmentioning

confidence: 99%

“…This property, known as neuroplasticity, has been demonstrated extensively in many brain regions by functional and structural magnetic resonance imaging (MRI) in the past two decades. In terms of brain lesions, including those resulting from brain injuries, strokes, and brain tumors, functional imaging studies have identified the brain to maintain its original features or to support functional recovery by recruiting other parts of the brain, such as the perilesional brain, contralesional brain, and homologous function of the brain, in order to compensate for lost functions (Small et al, 2002;Freundlieb et al, 2015;Fisicaro et al, 2016;Han et al, 2017Han et al, , 2018.…”

Section: Introductionmentioning

confidence: 99%

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Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

et al. 2020

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Background: The human brain has an extraordinary ability to functionally change or reorganize its structure in response to disease. The aim of this study is to assess the structural and functional plasticity of contralesional medial temporal lobe (MTL) in patients with unilateral MTL glioma.Methods: Sixty-eight patients with unilateral MTL glioma (left MTL glioma, n = 33; right MTL glioma, n = 35) and 40 healthy controls were recruited and scanned with 3D T1 MRI and rest-fMRI. We explored the structure of the contralesional MTL using voxelbased morphometry (VBM) and assessed the memory networks of the contralesional hemisphere using resting-state functional connectivity (rs-FC). The association between FC and cognitive function was assessed with partial correlation analysis.Results: Compared with healthy controls, both patient groups exhibited (1) a large cluster of voxels with gray matter (GM) volume decrease in the contralesional MTL using region of interest (ROI)-based VBM analysis (cluster level p < 0.05, FDR corrected); and (2) decreased intrahemispheric FC between the posterior hippocampus (pHPC) and posterior cingulate cortex (PCC) (p < 0.01, Bonferroni corrected). Intrahemispheric FC between the pHPC and PCC was positively correlated with cognitive function in both patient groups.Conclusion: Using multi-modality brain imaging tools, we found structural and functional changes in the contralesional MTL in patients with unilateral MTL glioma. These findings suggest that the contralesional cortex may have decompensation of structure and function in patients with unilateral glioma, except for compensatory structural and functional adaptations. Our study provides additional insight into the neuroanatomical and functional network changes in the contralesional cortex in patients with glioma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

et al. 2020

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“…Cerebral plasticity is the biological dynamic ability of the central nervous system to reorganize itself in response to injuries, such as damages caused by brain tumors [1, 2]. The reorganization of functional areas is a fundamental mechanism to compensate for impaired function [3].…”

Section: Introductionmentioning

confidence: 99%

Role of Functional Imaging Techniques to Assess Motor and Language Cortical Plasticity in Glioma Patients: A Systematic Review

et al. 2019

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Cerebral plasticity is the ability of the central nervous system to reorganize itself in response to different injuries. The reshaping of functional areas is a crucial mechanism to compensate for damaged function. It is acknowledged that functional remodeling of cortical areas may occur also in glioma patients. Principal limits of previous investigations on cortical plasticity of motor and language functions included scarce reports of longitudinal evaluations and limited sample sizes. This systematic review is aimed at elucidating cortical brain plasticity for motor and language functions, in adult glioma patients, by means of preoperative and intraoperative mapping techniques. We systematically reviewed the literature for prospective studies, assessing cortical plasticity of motor and language functions in low-grade and high-grade gliomas. Eight longitudinal studies investigated cortical plasticity, evaluated by motor and language task-based functional MRI (fMRI), motor navigated transcranial magnetic stimulation (n-TMS), and intraoperative mapping with cortical direct electrocortical stimulation (DES) of language and motor function. Motor function reorganization appeared relatively limited and mostly characterized by intrahemispheric functional changes, including secondary motor cortices. On the other hand, a high level of functional reshaping was found for language function in DES studies. Occurrence of cortical functional reorganization of language function was described focusing on the intrahemispheric recruitment of perilesional areas. However, the association between these functional patterns and recovery of motor and language deficits still remains partially clear. A number of relevant methodological issues possibly affecting the finding generalization emerged, such as the complexity of plasticity outcome measures and the lack of large longitudinal studies. Future studies are required to further confirm these evidences on cortical plasticity in larger samples, combining both functional imaging and intraoperative mapping techniques in longitudinally evaluations.

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“…While traditional MR imaging can accurately identify the anatomic relationship of critical brain regions with AVMs, it does not provide information regarding functional connectivity, and it fails to account for the plasticity of brain function that has been shown to occur in the context of underlying brain lesions or injury (22,23). AVM proximity to eloquent cortex, in addition to nidus size and venous drainage, is a major contributing factor to patient morbidity and postoperative neurologic decline (23).…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Functional Mapping and Cortical Reorganization in the Setting of Arteriovenous Malformations, Redefining Anatomical Eloquence

et al. 2020

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The goal of this study was to systematically review functional mapping and reorganization that takes place in the setting of arteriovenous malformations (AVMs) and its potential impact on grading and surgical decision making. Methods: A systematic literature review was performed using the PubMed database for studies published between 1986 and 2019. Studies assessing brain mapping and functional reorganization in AVMs were included. Results: Of the total 84 articles identified in the original literature search, 12 studies were ultimately selected. This includes studies evaluating the impact of cortical reorganization on patient outcomes and factors impacting and triggering cortical reorganization in AVM. Conclusion: These studies demonstrate the utility of preoperative brain mapping and acknowledgment of functional reorganization in the setting of AVMs. While these findings led to alterations in Spetzler-Martin grading and subsequent surgical decision making, it remains unclear the clinical utility of this information when assessing patient outcomes. While promising, more research is required before recommendations can be made regarding functional brain mapping and cortical reorganization with respect to AVM surgery involving eloquent brain tissue.

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Cortical Plasticity in the Setting of Brain Tumors

Cited by 42 publications

References 32 publications

Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

Role of Functional Imaging Techniques to Assess Motor and Language Cortical Plasticity in Glioma Patients: A Systematic Review

Systematic Review of Functional Mapping and Cortical Reorganization in the Setting of Arteriovenous Malformations, Redefining Anatomical Eloquence

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