Cortical projections to the periaqueductal grey in the cat: A retrograde horseradish peroxidase study

Bragin, E. O.; Yeliseeva, Z.V.; Василенко, Г. Ф.; Meizerov, E. E.; Chuvin, B. T.; Durinyan, R. A.

doi:10.1016/0304-3940(84)90563-9

Cited by 44 publications

(21 citation statements)

References 12 publications

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“…The PAG receives projections from insula, anterior cingulate, nucleus accumbens, amygdala, and frontal cortex (Bragin et al, 1984;Ma and Han, 1991;Rizvi et al, 1992). Microstimulation of ventrolateral OFC in rats transiently attenuates nociceptive reflex responses, and this effect is blocked by lesion of the PAG (Zhang et al, 1997(Zhang et al, , 1998.…”

Section: Functional Neuroanatomy Of Placebo Analgesiamentioning

confidence: 99%

Neurobiological Mechanisms of the Placebo Effect

Benedetti¹,

Mayberg²,

Wager³

et al. 2005

J. Neurosci.

636

394

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Section: Functional Neuroanatomy Of Placebo Analgesiamentioning

confidence: 99%

Neurobiological Mechanisms of the Placebo Effect

Benedetti¹,

Mayberg²,

Wager³

et al. 2005

J. Neurosci.

636

394

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“…Pyramidal cells in layer V project to subcortical structures such as the hypothalamus and periaqueductal grey 24 , the latter of which is involved in the descending modulation of spinal sensory transmission (FIG. 1).…”

mentioning

confidence: 99%

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

et al. 2016

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The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this Review, we discuss increasing evidence from rodent studies that ACC activation contributes to chronic pain states and describe several forms of synaptic plasticity that may underlie this effect. In particular, one form of long-term potentiation (LTP) in the ACC, which is triggered by the activation of NMDA receptors and expressed by an increase in AMPA-receptor function, sustains the affective component of the pain state. Another form of LTP in the ACC, which is triggered by the activation of kainate receptors and expressed by an increase in glutamate release, may contribute to pain-related anxiety.

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“…Interestingly, the somatosensory cortex also projects to the nucleus raphé magnus and periaqueductal gray (Bragin et al, 1984; O'Hearn and Molliver, 1984). While the raphe nucleus is involved in both fear responses (Kiser et al, 1980) and respiratory control (Sessle et al, 1981), the periaqueductal gray mediates defensive behavior (Bittencourt et al, 2005; Schenberg et al, 2005) panic anxiety (Jenck et al, 1995; Schenberg et al, 2001) and suffocation (Kumar et al, 1997) among other autonomic responses.…”

Section: Discussionmentioning

confidence: 99%

Chronic immobilization stress occludes in vivo cortical activation in an animal model of panic induced by carbon dioxide inhalation

Rahman

Kerskens

Chattarji

et al. 2014

Front. Behav. Neurosci.

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Breathing high concentrations of carbon dioxide (CO2) can trigger panic and anxiety in humans. CO2 inhalation has been hypothesized to activate neural systems similar to those underlying fear learning, especially those involving the amygdala. Amygdala activity is also upregulated by stress. Recently, however, a separate pathway has been proposed for interoceptive panic and anxiety signals, as patients exhibited CO2-inhalation induced panic responses despite bilateral lesions of the amygdala. This paradoxical observation has raised the possibility that cortical circuits may underlie these responses. We sought to examine these divergent models by comparing in vivo brain activation in unstressed and chronically-stressed rats breathing CO2. Regional cerebral blood flow measurements using functional Magnetic Resonance Imaging (fMRI) in lightly-anaesthetized rats showed especially strong activation of the somatosensory cortex by CO2 inhalation in the unstressed group. Strikingly, prior exposure to chronic stress occluded this effect on cortical activity. This lends support to recent clinical observations and highlights the importance of looking beyond the traditional focus on limbic structures, such as the hippocampus and amygdala, to investigate a role for cortical areas in panic and anxiety in humans.

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Cortical projections to the periaqueductal grey in the cat: A retrograde horseradish peroxidase study

Cited by 44 publications

References 12 publications

Neurobiological Mechanisms of the Placebo Effect

Neurobiological Mechanisms of the Placebo Effect

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

Chronic immobilization stress occludes in vivo cortical activation in an animal model of panic induced by carbon dioxide inhalation

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