Cortical reorganization consistent with spike timing–but not correlation-dependent plasticity

Young, J. M.; Waleszczyk, Wioletta J.; Wang, Chun; Calford, Michael B.; Dreher, Bogdan; Obermayer, Klaus

doi:10.1038/nn1913

Cited by 80 publications

(67 citation statements)

References 47 publications

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“…Additionally, as horizontal input leads intra-LPZ responses during the recovery process, the reversal of spike order may trigger spike time-dependent plasticity (STDP)-like alterations in synaptic transmission. Indeed, computational models implicate STDPdependent reorganization after monocular retinal lesion in cat or after whisker trimming in rat barrel cortex (41,42). At the population level, these plastic changes in synaptic transmission are most likely reflected by strengthened lateral activation, as observed in our study.…”

Section: Reinforcement Of Lateral Activation: Structural and Functionsupporting

confidence: 67%

Strengthening of lateral activation in adult rat visual cortex after retinal lesions captured with voltage-sensitive dye imaging in vivo

Palagina¹,

Eysel²,

Jancke

2009

Proc. Natl. Acad. Sci. U.S.A.

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Sensory deprivation caused by peripheral injury can trigger functional cortical reorganization across the initially silenced cortical area. It is proposed that intracortical connectivity enables recovery of function within such a lesion projection zone (LPZ), thus substituting lost subcortical input. Here, we investigated retinal lesioninduced changes in the function of lateral connections in the primary visual cortex of the adult rat. Using voltage-sensitive dye recordings, we visualized in millisecond-time resolution spreading synaptic activity across the LPZ. Shortly after lesion, the majority of neurons within the LPZ were subthresholdly activated by delayed propagation of activity that originated from unaffected cortical regions. With longer recovery time, latencies within the LPZ gradually decreased, and activation reached suprathreshold levels. Targeted electrode recordings confirmed that receptive fields of intra-LPZ neurons were displaced to the retinal lesion border while displaying normal orientation and direction selectivity. These results corroborate the view that cortical horizontal connections have a central role in functional reorganization, as revealed here by progressive facilitation of synaptic activity and the traveling wave of excitation that propagates horizontally into the deprived cortical region.horizontal connections ͉ plasticity ͉ striate cortex

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Section: Reinforcement Of Lateral Activation: Structural and Functionsupporting

confidence: 67%

Strengthening of lateral activation in adult rat visual cortex after retinal lesions captured with voltage-sensitive dye imaging in vivo

Palagina¹,

Eysel²,

Jancke

2009

Proc. Natl. Acad. Sci. U.S.A.

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“…Possible mechanisms of action for gVRT are as follows: (1) plasticity in the retina 6 ; (2) changes at higher processing levels in the geniculate 70 or the primary visual cortex, such as receptive field changes [12][13][14] ; (3) improved visual attention 33 ; (4) normal perceptual learning 6 ; or (5) a combination thereof. The fact that detection accuracy gains in glaucoma were not predominantly found in ARVs (as was seen in hemianopia 6 ) suggests that surviving retinal ganglion cells deep in the damaged zones might contribute to vision restoration or changes in intact visual field sectors.…”

Section: Research Original Investigationmentioning

confidence: 99%

Vision Restoration Training for Glaucoma

Sabel

Gudlin

2014

JAMA Ophthalmol

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IMPORTANCE Visual field loss due to retinal damage is considered irreversible, and methods are needed to achieve vision restoration. Behavioral vision training, shown to improve visual fields in hemianopia and optic nerve damage, might comprise such a method. OBJECTIVE To determine if behavioral activation of areas of residual vision using daily 1-hour vision restoration training for glaucoma for 3 months improves detection accuracy compared with placebo. DESIGN AND SETTING Prospective, double-blind, randomized, placebo-controlled clinical trial in an ambulatory care and home training setting. PARTICIPANTS Volunteer sample of patients with glaucoma (mean age, 61.7 years; age range, 39-79 years) with stable visual fields and well-controlled intraocular pressure. After randomization, 4 patients withdrew from the trial because of mild headaches (n = 2) or lack of time to complete the schedule (n = 2). INTERVENTIONS Computer-based vision restoration training for glaucoma (n = 15) or visual discrimination placebo training in the intact visual field (n = 15). MAIN OUTCOMES AND MEASURESThe primary end point was change in detection accuracy in high-resolution perimetry. Secondary end points were 30°white-on-white and 30°b lue-on-yellow near-threshold perimetry, as well as reaction time, eye movements, and vision-related and health-related quality of life.RESULTS Vision restoration training for glaucoma led to significant detection accuracy gains in high-resolution perimetry (P = .007), which were not found with white-on-white or blue-on-yellow perimetry. Furthermore, the pre-post differences after vision restoration training for glaucoma were greater compared with placebo in all perimetry tests (P = .02 for high-resolution perimetry, P = .04 for white on white, and P = .04 for blue on yellow), and these results were independent of eye movements. Vision restoration training for glaucoma (but not placebo) also led to faster reaction time (P = .009). Vision-related quality of life was unaffected, but the health-related quality-of-life mental health domain increased in both groups.CONCLUSIONS AND RELEVANCE Visual field defects caused by glaucoma can be improved by repetitively activating residual vision through training the visual field borders and areas of residual vision, thereby increasing their detection sensitivity. Our randomized clinical trial revealed evidence that visual field loss is in part reversible by behavioral, computer-based, online controlled vision training, comprising a new rehabilitation treatment option in glaucoma. Neuroplasticity of the visual cortex or higher cortical areas is the proposed mechanism of action.TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT01799707.

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“…Gerstner started to report the first spike-timing-dependent learning algorithms [10,11] in 1993. STDP has been shown to be better than Hebbian correlation-based plasticity at explaining cortical phenomena [23,24] and has been proven successful in learning hidden spiking patterns [20] or performing competitive spike pattern learning [21]. Astonishingly, experimental evidence of STDP has been reported by neuroscience groups during the past decade [31][32][33][34][35][36][37][38], so today we can state that the physiological existence of STDP has been reasonably well established.…”

Section: Spike-timing-dependent Plasticitymentioning

confidence: 99%

Spike-Timing-Dependent-Plasticity in Hybrid Memristive-CMOS Spiking Neuromorphic Systems

Serrano-Gotarredona

Linares-Barranco

2013

Memristors and Memristive Systems

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Cortical reorganization consistent with spike timing–but not correlation-dependent plasticity

Cited by 80 publications

References 47 publications

Strengthening of lateral activation in adult rat visual cortex after retinal lesions captured with voltage-sensitive dye imaging in vivo

Strengthening of lateral activation in adult rat visual cortex after retinal lesions captured with voltage-sensitive dye imaging in vivo

Vision Restoration Training for Glaucoma

Spike-Timing-Dependent-Plasticity in Hybrid Memristive-CMOS Spiking Neuromorphic Systems

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