Cortical signature related to psychometric properties of pain vigilance in healthy individuals: A voxel-based morphometric study

Nagasaka, Kazuaki; Otsuru, Naofumi; Sato, Rui; Watanabe, Hiraku; Sakurai, Noriko; Ohno, Ken; Kodama, Naoki; Onishi, Hideaki

doi:10.1016/j.neulet.2022.136445

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…More specifically, the GM density of the right parahippocampal gyrus was also negatively correlated with the pain intensity of PHN patients. Therefore, It is implicated that chronic pain of PHN significantly affects these secondary integrated brain regions, which is consistent with the previous results of most VBM studies of other chronic neuropathic pain 24 …”

Section: Discussionsupporting

confidence: 90%

“…Therefore, It is implicated that chronic pain of PHN significantly affects these secondary integrated brain regions, which is consistent with the previous results of most VBM studies of other chronic neuropathic pain. 24 The role of these changes in the structure of secondary integrated brain regions in PHN and other neuropathic pain is still unclear: Although most of the current academic consensus supports the idea that chronic pain causes changes in brain fitness, other studies have found that damage to certain brain regions can also contribute to chronic pain, and in most cases, the relationship between the two may be mutually reinforcing. For example, axons from the insula are connected to the frontal cortex and participate in the integration process of sensory information from back to front, which is one of the components of the attention network and the salience network.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cerebral structural alterations in the patients undergoing postherpetic neuralgia: A VBM–MRI study

Niu

Yuan

et al. 2022

Ibrain

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This study aimed to investigate the changes in gray matter (GM) volume and density in patients with postherpetic neuralgia (PHN). Using voxel-based morphometry (VBM), the differences in cerebral GM volume and concentration between 25 PHN patients and 25 healthy controls with similar gender ratios, ages, and education were compared. Meanwhile, correlation analysis was performed between the value of GM volume/concentration in the brain areas with discrepancy and the visual analog scale (VAS) score/lesion duration. The global GM volume in PHN patients was lower than that of healthy controls, while the total volume of cerebrospinal fluid in PHN patients was higher than that of healthy controls. In PHN patients, the GM volume decreased in the striatum, cerebellum, precentral gyrus, middle frontal gyrus, parahippocampal gyrus, postcentral gyrus, and so forth; the GM concentration decreased in the striatum, insula, middle and posterior cingulate, and superior temporal gyrus. There was a negative correlation between GM concentration in the right parahippocampal gyrus and the VAS in patients with PHN. In PHN patients, GM volume and density in the brain regions involved in nociceptive sensation, pain perception, and integration decreased significantly. The interaction between chronic pain of PHN and alteration of the cerebral structure may contribute to the occurrence and development of PHN.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%