Cortical sources of resting state electroencephalographic rhythms differ in relapsing–remitting and secondary progressive multiple sclerosis

Babiloni, Claudio; Percio, Claudio Del; Capotosto, Paolo; Noce, Giuseppe; Infarinato, Francesco; Muratori, Chiara; Marcotulli, Christian; Bellagamba, Gauthier; Righi, Elena; Soricelli, Andrea; Onorati, Paolo; Lupattelli, Tommaso

doi:10.1016/j.clinph.2015.05.029

Cited by 25 publications

(19 citation statements)

References 67 publications

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“…Pathologic cortical delta waves may result from damage in the midbrain and localized white matter lesions (Gloor et al, 1977; Schaul, 1990; Schaul et al, 1981) and brain inflammatory conditions (Westmoreland, 2005). Indeed, our finding of abnormal delta activity in patients with CFS is also consistent with delta findings related to other neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (Babiloni et al, 2013; Babiloni et al, 2016; Nishida et al, 2011). …”

Section: Discussionsupporting

confidence: 90%

Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome

Zinn

Valencia

et al. 2018

Biological Psychology

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We investigated central fatigue in 50 patients with chronic fatigue syndrome (CFS) and 50 matched healthy controls (HC). Resting state EEG was collected from 19 scalp locations during a 3 min, eyes-closed condition. Current densities were localized using exact low-resolution electromagnetic tomography (eLORETA). The Multidimensional Fatigue Inventory (MFI-20) and the Fatigue Severity Scale (FSS) were administered to all participants. Independent t-tests and linear regression analyses were used to evaluate group differences in current densities, followed by statistical non-parametric mapping (SnPM) correction procedures. Significant differences were found in the delta (1-3 Hz) and beta-2 (19-21 Hz) frequency bands. Delta sources were found predominately in the frontal lobe, while beta-2 sources were found in the medial and superior parietal lobe. Left-lateralized, frontal delta sources were associated with a clinical reduction in motivation. The implications of abnormal cortical sources in patients with CFS are discussed.

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Section: Discussionsupporting

confidence: 90%

Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome

Zinn

Valencia

et al. 2018

Biological Psychology

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“…Electroencephalography (EEG) recordings from MS patients have revealed aberrant low-amplitude cortical alpha waves and the appearance of delta waves in awake patients (Babiloni et al, 2016), while MS with seizures (MS+S) patients display these changes and exhibit waking theta frequencies and paroxysmal discharges (Ghezzi et al, 1990). Magnetic resonance imaging (MRI) of MS+S patients demonstrates abundant temporal leukocortical lesions, and hippocampal accumulation of demyelinating foci (Kutzelnigg et al, 2005; Martinez-Lapiscina et al, 2013; Cawley et al, 2015; Calabrese et al, 2016) in addition to findings common to MS, such as global cortical thinning and ventricular hypertrophy (Zivadinov et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chronic demyelination-induced seizures

et al. 2017

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Multiple sclerosis (MS) patients are three to six times more likely to develop epilepsy compared to the rest of the population. Seizures are more common in patients with early onset or progressive forms of the disease and prognosticate rapid progression to disability and death. Grey matter atrophy, hippocampal lesions, interneuron loss, and elevated juxtacortical lesion burden have been identified in MS patients with seizures; however, translational studies aimed at elucidating the pathophysiological processes underlying MS epileptogenesis are limited. Here, we report that cuprizone-mediated chronically demyelinated (9-12 weeks) mice exhibit marked changes in electroencephalography (EEG) and evidence of overt seizure activity in mice. Subsequently, histopathological correlates were probed by immunohistochemistry, revealing extensive demyelination, loss of parvalbumin inhibitory interneurons in the hippocampus CA1 subregion, widespread gliosis and changes to astrocytic aquaporin-4 expression. Our results suggest that chronically demyelinated mice are a valuable model with which we may begin to understand the mechanisms underlying demyelination-induced seizures.

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“…Furthermore, delta cortical slowing can result from a decrease in the afferent drive due to white matter or subcortical lesions to deep midline areas (Gloor, Ball, & Schaul, 1977;Schaul, Gloor, & Gotman, 1981). Finding abnormal small-worldness in delta suggests there may be some similarities between CFS and Alzheimer's disease (Babiloni et al, 2013;Hata et al, 2016), multiple sclerosis (Babiloni et al, 2016), and Parkinson's disease (Babiloni et al, 2011), where abnormal delta sources have been detected. This is the first study to measure small-world properties in CFS in terms of the small-worldness index.…”

Section: Discussionmentioning

confidence: 99%

Small-World Network Analysis of Cortical Connectivity in Chronic Fatigue Syndrome Using Quantitative EEG

Zinn

Jason

2017

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The aim of this study was to explore the relationship between complex brain networks in people with Chronic Fatigue Syndrome (CFS) and neurocognitive impairment. Quantitative EEG (qEEG) recordings were taken from 14 people with CFS and 15 healthy controls (HCs) during an eye-closed resting condition. Exact low resolution electromagnetic tomography (eLORETA) was used to estimate cortical sources and perform a functional connectivity analysis. The graph theory approach was used to characterize network representations for each participant and derive the "small-worldness" index, a measure of the overall homeostatic balance between local and long-distance connectedness. Results showed that small-worldness for the delta band was significantly lower for patients with CFS compared to HCs. In addition, delta small-worldness was negatively associated with neurocognitive impairment scores on the DePaul Symptom Questionnaire (DSQ). Finally, delta small-worldness indicated a greater risk of complex brain network inefficiency for the CFS group. These results suggest that CFS pathology may be functionally disruptive to small-world networks. In turn, small-world characteristics might serve as a neurophysiological indicator for confirming a biological basis of cognitive symptoms, treatment outcome, and neurophysiological status of people with CFS.

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Cortical sources of resting state electroencephalographic rhythms differ in relapsing–remitting and secondary progressive multiple sclerosis

Cited by 25 publications

References 67 publications

Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome

Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome

Chronic demyelination-induced seizures

Small-World Network Analysis of Cortical Connectivity in Chronic Fatigue Syndrome Using Quantitative EEG

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