Cortical stimulation during learning in rabbits

Proctor, Florry; Pinto-Hamuy, Teresa; Kupferman, Irving

doi:10.1016/0028-3932(64)90037-5

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…In accordance with the modulating effects of DCS on spontaneous neuronal activity, numerous animal experiments have demonstrated a polarity‐specific alteration of learning and memory formation by DCS (Morrell & Naitoh, 1962; Proctor et al 1964; Albert, 1966; Rosen & Stamm, 1972). The DCS‐induced postsynaptic alteration of membrane polarization in the presence of presynaptic neuronal activity shares some similarities with STDP.…”

mentioning

confidence: 65%

The pharmacology of neuroplasticity induced by non‐invasive brain stimulation: building models for the clinical use of CNS active drugs

Nitsche

Müller‐Dahlhaus

Paulus

et al. 2012

The Journal of Physiology

177

119

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The term neuroplasticity encompasses structural and functional modifications of neuronal connectivity. Abnormal neuroplasticity is involved in various neuropsychiatric diseases, such as dystonia, epilepsy, migraine, Alzheimer's disease, fronto-temporal degeneration, schizophrenia, and post cerebral stroke. Drugs affecting neuroplasticity are increasingly used as therapeutics in these conditions. Neuroplasticity was first discovered and explored in animal experimentation. However, non-invasive brain stimulation (NIBS) has enabled researchers recently to induce and study similar processes in the intact human brain. Plasticity induced by NIBS can be modulated by pharmacological interventions, targeting ion channels, or neurotransmitters. Importantly, abnormalities of plasticity as studied by NIBS are directly related to clinical symptoms in neuropsychiatric diseases. Therefore, a core theme of this review is the hypothesis that NIBS-induced plasticity can explore and potentially predict the therapeutic efficacy of CNS-acting drugs in neuropsychiatric diseases. We will (a) review the basics of neuroplasticity, as explored in animal experimentation, and relate these to our knowledge about neuroplasticity induced in humans by NIBS techniques. We will then (b) discuss pharmacological modulation of plasticity in animals and humans. Finally, we will (c) review abnormalities of plasticity in neuropsychiatric diseases, and discuss how the combination of NIBS with pharmacological intervention may improve our understanding of the pathophysiology of abnormal plasticity in these diseases and their purposeful pharmacological treatment.Ulf Ziemann (far left) is clinical director of the Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Germany. His expertise is in clinical neurophysiology with focus on motor cortical excitability, plasticity, learning and neurorehabilitation. He has developed the field of pharmaco-TMS, which provides important knowledge on the physiology of TMS measures of excitability and the pharmacological regulation of plasticity in human motor cortex. Florian Müller-Dahlhaus (centre left) is resident at the Department of Neurology, Goethe-University Frankfurt, Germany. He has expertise in cellular electrophysiology and imaging as well as pharmaco-TMS. Research focuses on understanding mechanisms of neural plasticity involved in motor learning to enhance rehabilitation post stroke. Walter Paulus (centre right) is clinical director of the Department of Clinical Neurophysiology, University Medical Centre, Germany. He investigates motor cortex physiology by means of transcranial stimulation, further refined by co-application of CNS-active drugs. He was involved in the development of new stimulation methods for induction of neuroplasticity such as tDCS, tACS and tRNS. His clinical focus encompasses Parkinson's disease, restless legs syndrome, epilepsy and pain. Michael A. Nitsche (far right) is a consultant in the same department. His ...

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confidence: 65%

The pharmacology of neuroplasticity induced by non‐invasive brain stimulation: building models for the clinical use of CNS active drugs

Nitsche

Müller‐Dahlhaus

Paulus

et al. 2012

The Journal of Physiology

177

119

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“…Transkranielle kathodale Polarisation bilateral über dem visuellen Kortex verursachte bei Kaninchen eine Abnahme der konditionierten Vermeidungsantworten, wenn als konditionierende Stimuli Lichtblitze benutzt wurden[25]. Kathodale Stimulation über dem auditorischen Kortex des Kaninchens verschlechterte auditorische Lernleistungen[26]. Anodale Stimulation des medialen Kortex der Ratte führte zu einer Verbesserung in einer interhemisphärischen Transferaufgabe bei der Ratte, wohingegen kathodale Stimulation diese verschlechterte[27].…”

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Erzeugung und Modulation von Neuroplastizität durch transkranielle Gleichstromstimulation beim Menschen

Nitsche¹,

Antal²,

Liebetanz³

et al. 2004

Klin Neurophysiol

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Electrophysiological and behavioral effects of transcortical polarizing current: Comparison with the behaviorally determined characteristics of learning

Szeligo

1976

Brain Research

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Cortical stimulation during learning in rabbits

Cited by 7 publications

References 15 publications

The pharmacology of neuroplasticity induced by non‐invasive brain stimulation: building models for the clinical use of CNS active drugs

The pharmacology of neuroplasticity induced by non‐invasive brain stimulation: building models for the clinical use of CNS active drugs

Erzeugung und Modulation von Neuroplastizität durch transkranielle Gleichstromstimulation beim Menschen

Electrophysiological and behavioral effects of transcortical polarizing current: Comparison with the behaviorally determined characteristics of learning

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