2003
DOI: 10.1179/016164103771953871
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Cortical stimulation improves skilled forelimb use following a focal ischemic infarct in the rat

Abstract: Improving functional recovery following cerebral strokes in humans will likely involve augmenting brain plasticity. This study examined skilled forelimb behavior, neocortical evoked potentials, and movement thresholds to assess cortical electrical stimulation concurrent with rehabilitative forelimb usage following a focal ischemic insult. Adult rats were trained on a task that required skilled usage of both forelimbs. They then underwent an acute focal ischemic insult to the caudal forelimb area of sensorimoto… Show more

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Cited by 151 publications
(130 citation statements)
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“…This finding is in agreement with previous data indicating that monopolar or bipolar CS delivered at frequencies between 50 and 100 Hz and at 40 to 70 % of movement thresholds greatly improves reaching performance compared to unstimulated reach trained controls (Adkins-Muir and Jones, 2003;Kleim et al, 2003b;Plautz et al, 2003;Teskey et al, 2003;Adkins et al, 2006b) and rats receiving 250 Hz CS during training (Adkins-Muir and Jones, 2003). CS and motor training was initiated 2 weeks after the infarcts in the present study, but it is also effective when delivered at earlier (Kleim et al, 2003b;Teskey et al, 2003) and later (Plautz et al, 2003) time points. The present results extend the previous behavioral findings by indicating that CS also partially improves abnormalities in the movements used to perform the reaching task.…”
Section: Motor Cortical Stimulation Improves Reaching Function In Thesupporting
confidence: 93%
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“…This finding is in agreement with previous data indicating that monopolar or bipolar CS delivered at frequencies between 50 and 100 Hz and at 40 to 70 % of movement thresholds greatly improves reaching performance compared to unstimulated reach trained controls (Adkins-Muir and Jones, 2003;Kleim et al, 2003b;Plautz et al, 2003;Teskey et al, 2003;Adkins et al, 2006b) and rats receiving 250 Hz CS during training (Adkins-Muir and Jones, 2003). CS and motor training was initiated 2 weeks after the infarcts in the present study, but it is also effective when delivered at earlier (Kleim et al, 2003b;Teskey et al, 2003) and later (Plautz et al, 2003) time points. The present results extend the previous behavioral findings by indicating that CS also partially improves abnormalities in the movements used to perform the reaching task.…”
Section: Motor Cortical Stimulation Improves Reaching Function In Thesupporting
confidence: 93%
“…Nevertheless, movement threshold were similar to a previous study using epidural electrodes and between groups. Also consistent with previous findings (Adkins-Muir and Jones, 2003;Teskey et al, 2003), movement thresholds declined over days (F(2,84) = 4.19, p = 0.02). The severely impaired group tended to show less of a decline in movement threshold current levels, but there was no significant difference between groups (p = 0.81) or group by day interaction effect (p = 0.09).…”
Section: Nih-pa Author Manuscriptsupporting
confidence: 92%
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