Cortical surface architecture endophenotype and correlates of clinical diagnosis of autism spectrum disorder

Yamagata, Bun; Itahashi, Takashi; Fujino, Junya; Ohta, Haruhisa; Takashio, Osamu; Nakamura, Motoaki; Kato, Nobuo; Mimura, Masaru; Hashimoto, Ryu ichiro; Aoki, Yuta

doi:10.1111/pcn.12854

Cited by 12 publications

(17 citation statements)

References 59 publications

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“…Such an increase of GI referred to the altered cortical folding and supported by previous studies, reporting increased local GI in the autistic brain 35 , 40 , 65 . FD, a measure of cortical complexity, statistically differed between ASD and TD groups of children in postcentral gyrus and banks of superior temporal sulcus in the left hemisphere and rostral middle frontal gyrus in the right hemisphere, which is also consistent with the previous studies, revealing atypical FD in ASD 10 , 38 . SD was the single surface-based parameter which did not significantly differed between groups of children in any ROIs which is contrary to Nordahl et al study 42 .…”

Section: Discussionsupporting

confidence: 90%

“…Other surface abnormalities, such as alterations in gyrification, sulcus depth, and fractal dimension/cortical (or folding) complexity, have also been observed in children with ASD 35 – 38 . Several studies, addressing Gyrification Index (GI), have shown the relationships between atypical GI in such language-related cortical regions as the temporal and inferior parietal cortices and the language abilities of children with ASD 39 , 40 .…”

Section: Introductionmentioning

confidence: 99%

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Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder

Arutiunian

Gomozova²,

Minnigulova³

et al. 2023

Sci Rep

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Language impairment is comorbid in most children with Autism Spectrum Disorder (ASD) but its neural basis is poorly understood. Using structural magnetic resonance imaging (MRI), the present study provides the whole-brain comparison of both volume- and surface-based characteristics between groups of children with and without ASD and investigates the relationships between these characteristics in language-related areas and the language abilities of children with ASD measured with standardized tools. A total of 36 school-aged children participated in the study: 18 children with ASD and 18 age- and sex-matched typically developing controls. The results revealed that multiple regions differed between groups of children in gray matter volume, gray matter thickness, gyrification, and cortical complexity (fractal dimension). White matter volume and sulcus depth did not differ between groups of children in any region. Importantly, gray matter thickness and gyrification of language-related areas were related to language functioning in children with ASD. Thus, the results of the present study shed some light on the structural brain abnormalities associated with language impairment in ASD.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder

Arutiunian

Gomozova²,

Minnigulova³

et al. 2023

Sci Rep

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“…Cytogenetic abnormalities at the 15q11-q13 locus are fairly frequent in people with autism, and a "chromosome 15 phenotype" was described in individuals with chromosome 15 duplications. Among other candidate genes are the FOXP2, RAY1/ ST7, IMMP2L, and RELN genes at 7q22-q33 and the GABA(A) receptor subunit and UBE3A genes on chromosome 15q11-q13 [100].…”

Section: The Genetic Architecture Of Asdmentioning

confidence: 99%

Autism Spectrum Disorder (ASD) in a Developing country. A Clinical and Descriptive Study of 75 Infant and Young Patients

Galindez

et al. 2019

BJSTR

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Seventy five (75) infant patients, from 3-15 years old, clinically diagnosed with autism spectrum disorder exhibited disconnected brain with social isolation (80%), hyperconnected children (5%), creative child (Asperger syndrome) (10%), stereotyped movements of hands and body trunk (10%), hyperactivity and attention deficit (10%), language disorders such as delay in the onset of language or early vocalization, regressive changes of language, mutism, gestual language, escatologic language, digital language (5%), learning and memory deficit (10%), psychomotor delay (5%), behavioral changes, such as aggresivity and autoagressivity (10%), tactile hypersensitivity, crisis of cry (1%), separation anxiety (1%), mood disorders such as anxiety and depression (3%), photofobia (1%), loss of weight, (1%), routinised patterns of though and fantastic thoughts (2%).The following associated comorbidities: perinatal hypoxia, low weight at birth, behavioral abnormities, anxiety, auto-and heteroagressivity, hyperphagia, learning and hearing disorders, mainly hyperacusia, social isolation, cognitive deficit, sleeping disorders and parenteral abuse of child. Some non-nervous system comorbidities, such as allergic reaction, bronchial asthma and atopic dermatitis also were found. Some locomotor abnormalities as genus valgo and flat feet were also observed. The mothers exhibited some of the followings diseases during pregnancy: urinary infections, behavioral disturbances like anxiety, fobias, hyperactivity, toxoplasmosis and Zika virus infections, hyperemesis, oligohydramnios and lost of amniotic fluid, twin pregnancy, pre-eclampsia, aging placenta, cesarean surgery, high blood pressure, maternal sepsis, diabetes, hepatic coma, hypotiroidism, viral hepatitis, obesity, and social parenteral problems, such as excessive work, low economy and poor social conditions, environmental contamination and labor and conjugal stress.

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“…Discovery of disease‐specific biomarkers or behavioral indicators with sufficient sensitivity is an important issue to improve the clinical diagnosis of mental illness. Magnetic resonance images, near‐infrared spectroscopy, genetic markers, cognitive functions, and eye movements are candidates . Of them, eye movement is representative of sensorimotor functions of the brain, and eye movement abnormalities have been reported in subjects with schizophrenia .…”

Section: Introductionmentioning

confidence: 99%

“…Magnetic resonance images, near-infrared spectroscopy, genetic markers, cognitive functions, and eye movements are candidates. [1][2][3][4][5][6] Of them, eye movement is representative of sensorimotor functions of the brain, and eye movement abnormalities have been reported in subjects with schizophrenia. [7][8][9] It has been frequently reported that subjects with schizophrenia can be successfully distinguished from healthy individuals by using eye movements.…”

Section: Introductionmentioning

confidence: 99%

Comparison of eye movements in schizophrenia and autism spectrum disorder

Shiino

Miura

Fujimoto

et al. 2019

Neuropsychopharm Rep

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Aim Eye movement abnormalities are often associated with psychiatric illness. Subjects with either schizophrenia or autism spectrum disorder (ASD) have been reported to show eye movement abnormalities. However, it is still unclear whether eye movement abnormalities in schizophrenia and in ASD have common features. This study aimed to understand the similarities/differences in eye movement abnormalities of subjects with schizophrenia and those with ASD. Methods We analyzed 75 eye movement characteristics of 83 subjects with schizophrenia, 17 subjects with ASD and 255 healthy controls that were collected during fixation, smooth pursuit and free viewing tasks using analysis of covariance with the covariates age and sex. Results We found significant effects across groups on 21 eye movement characteristics, of which 4 characteristics had large effect sizes. Post hoc multiple comparisons indicated significant differences between the subjects with schizophrenia and healthy controls across all 21 characteristics. On the other hand, no significant difference between the ASD group and healthy control group was found. Instead, the subjects with ASD showed significant differences from the subjects with schizophrenia in 5 eye movement characteristics during the free viewing and smooth pursuit eye movements. Conclusions The present results suggest that eye movement abnormalities in the subjects with ASD are different from those with schizophrenia and that the tasks in this study are suitable to detect eye movement abnormality in schizophrenia. Thus, the eye movement examinations used here may distinguish subjects with schizophrenia from those with ASD.

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Cortical surface architecture endophenotype and correlates of clinical diagnosis of autism spectrum disorder

Cited by 12 publications

References 59 publications

Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder

Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) in a Developing country. A Clinical and Descriptive Study of 75 Infant and Young Patients

Comparison of eye movements in schizophrenia and autism spectrum disorder

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