Cortical Temporal Dynamics of Visually Guided Behavior

Hinkley, Lbn; Nagarajan, SS; Dalal, Sarang S.; Guggisberg, AG; Disbrow, Emily

doi:10.1016/s1053-8119(09)70901-2

Cited by 2 publications

(3 citation statements)

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“…Upon hearing the prompter nouns, patients were instructed to think of either a verb or “action word” associated with the noun and to respond vocally into a microphone located in the MEG chamber, as depicted in Figure . Analysis of the verb generation task data was completed by an MEG technologist under the guidance of a neuroscientist using adaptive spatial filtering (Dalal et al, ; Findlay et al, ; Hinkley, Nagarajan, Dalal, Guggisberg, & Disbrow, ).…”

Section: Methodsmentioning

confidence: 99%

“…For example, for the response‐locked analysis, “−850” consists of the average of three 300 ms epochs (−1,000 to −700, −900 to −600, −800 to −500). For a detailed discussion, refer to Dalal et al, , and Hinkley et al, . Although Figures display whole brain activity, the VOI used in calculation of laterality index was more restricted.…”

Section: Methodsmentioning

confidence: 99%

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MEG imaging of recurrent gliomas reveals functional plasticity of hemispheric language specialization

Traut

Sardesh

Bulubas

et al. 2018

Human Brain Mapping

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In patients with gliomas, changes in hemispheric specialization for language determined by magnetoencephalography (MEG) were analyzed to elucidate the impact of treatment and tumor recurrence on language networks. Demonstration of reorganization of language networks in these patients has significant implications on the prevention of postoperative functional loss and recovery. Whole‐brain activity during an auditory verb generation task was estimated from MEG recordings in a group of 73 patients with recurrent gliomas. Hemisphere of language dominance was estimated using the language laterality index (LI), a measure derived from the task. The initial scan was performed prior to resection; patients subsequently underwent surgery and adjuvant treatment. A second scan was performed upon recurrence prior to repeat resection. The relationship between the shift in LI between scans and demographics, anatomic location, pathology, and adjuvant treatment was analyzed. Laterality shifts were observed between scans; the median percent change was 29.1% across all patients. Laterality shift magnitude and relative direction were associated with the initial position of language dominance; patients with increased lateralization experienced greater shifts than those presenting more bilateral representation. A change in LI from left or right to bilateral (or vice versa) occurred in 23.3% of patients; complete switch occurred in 5.5% of patients. Patients with tumors within the language‐dominant hemisphere experienced significantly greater shifts than those with contralateral tumors. The majority of patients with glioma experience shifts in language network organization over time which correlate with the relative position of language lateralization and tumor location.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

MEG imaging of recurrent gliomas reveals functional plasticity of hemispheric language specialization

Traut

Sardesh

Bulubas

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Andersen and Buneo, 2002;Fattori et al, 2001;Calton et al, 2002;Ferraina et al, 2009) and human MEG (e.g. Hinkley et al, 2011) and fMRI studies showed a parieto-frontal cortical network activated in the both planning and execution phases for complex actions such as reaching (e.g. Prado et al, 2005;Galati et al, 2011;Tosoni et al, 2014), grasping (for a review Gallivan and Culham, 2015), pantomime (Johnson-Frey et al, 2005), interaction with graspable-objects, especially tools (e.g.…”

Section: Parietal Activitymentioning

confidence: 99%