Cortical thinning 3 years after ischaemic stroke is associated with cognitive impairment and APOE ε4

Khlif, Mohamed Salah; Egorova-Brumley, Natalia; Bird, Laura; Werden, Emilio; Brodtmann, Amy

doi:10.1016/j.nicl.2022.103200

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…In terms of SBM analysis, poststroke patients exhibited decreased CT in the contralesional PreCG, lingual and fusiform gyrus, and IPL, in accordance with several previous studies (Aamodt et al, 2022; Salah Khlif et al, 2022), mirroring the atrophy of the contralesional hemisphere. There are several factors that can account for the thinning of the contralesional cortex, including ‘transcallosal diaschisis’, apoptosis induced by ipsilesional interneurons, Wallerian or retrograde degeneration of fibre tracts, and ‘non‐use cortical atrophy’ (Carrera & Tononi, 2014; Cheng et al, 2020; Kraemer et al, 2004).…”

Section: Discussionsupporting

confidence: 91%

Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke

Lu,

Xing,

et al. 2023

Eur J of Neuroscience

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The present study aimed to investigate poststroke morphological alterations contralesionally and correlations with functional outcomes. Structural magnetic resonance images were obtained from 27 poststroke patients (24 males, 50.21 ± 10.97 years) and 20 healthy controls (13 males, 46.63 ± 12.18 years). Voxel‐based and surface‐based morphometry analysis were conducted to detect alterations of contralesional grey matter volume (GMV), cortical thickness (CT), gyrification index (GI), sulcus depth (SD), and fractal dimension (FD) in poststroke patients. Partial correlation analysis was used to explore the relationship between regions with significant structural differences and scores of clinical assessments, including Modified Barthel Index (MBI), Berg Balance Scale (BBS), Fugl–Meyer Assessment of Upper Extremity (FMA‐UE), Mini‐Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA). Correction for multiplicity was conducted within each parameter and for all tests. GMV significantly decreased in the contralesional motor‐related, occipital and temporal cortex, limbic system, and cerebellum lobe (P < 0.01, family‐wise error [FWE] correction). Lower CT was found in the contralesional precentral and lingual gyrus (P < 0.01, FWE correction), while lower GI found in the contralesional superior temporal gyrus and insula (P < 0.01, FWE correction). There were significant correlations between GMV of contralesional lingual gyrus and MBI (P = 0.031, r = 0.441), and BBS (P = 0.047, r = 0.409) scores, and GMV of contralesional hippocampus and FMA‐UE scores (P = 0.048, r = 0.408). In conclusion, stroke patients exhibited wide grey matter loss and cortical morphological changes in the contralesional hemisphere, which correlated with sensorimotor functions and the ability of daily living.

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Section: Discussionsupporting

confidence: 91%

Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke

Lu,

Xing,

et al. 2023

Eur J of Neuroscience

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“…42 Moreover, the observed augmentation in cortical thickness within the prefrontal regions among the CVD group over a span of 2 years aligns with findings from an earlier investigation involving patients recovering from ischemic strokes within a 3-year poststroke period. 43 This phenomenon may potentially represent a compensatory response to the presence of ischemic lesions.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study

Rashidi‐Ranjbar,

Churchill,

Black

et al. 2024

Int J Geriat Psychiatry

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ObjectivesNeuropsychiatric symptoms (NPS) increase risk of developing dementia and are linked to various neurodegenerative conditions, including mild cognitive impairment (MCI due to Alzheimer's disease [AD]), cerebrovascular disease (CVD), and Parkinson's disease (PD). We explored the structural neural correlates of NPS cross‐sectionally and longitudinally across various neurodegenerative diagnoses.MethodsThe study included individuals with MCI due to AD, (n = 74), CVD (n = 143), and PD (n = 137) at baseline, and at 2‐years follow‐up (MCI due to AD, n = 37, CVD n = 103, and PD n = 84). We assessed the severity of NPS using the Neuropsychiatric Inventory Questionnaire. For brain structure we included cortical thickness and subcortical volume of predefined regions of interest associated with corticolimbic and frontal‐executive circuits.ResultsCross‐sectional analysis revealed significant negative correlations between appetite with both circuits in the MCI and CVD groups, while apathy was associated with these circuits in both the MCI and PD groups. Longitudinally, changes in apathy scores in the MCI group were negatively linked to the changes of the frontal‐executive circuit. In the CVD group, changes in agitation and nighttime behavior were negatively associated with the corticolimbic and frontal‐executive circuits, respectively. In the PD group, changes in disinhibition and apathy were positively associated with the corticolimbic and frontal‐executive circuits, respectively.ConclusionsThe observed correlations suggest that underlying pathological changes in the brain may contribute to alterations in neural activity associated with MBI. Notably, the difference between cross‐sectional and longitudinal results indicates the necessity of conducting longitudinal studies for reproducible findings and drawing robust inferences.

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“…The intervention group showed longitudinally slightly increased GM volume in the left BA44, whereas the control group showed a decline in that area. This most likely owes to the accelerated brain atrophy rate after stroke, which is 2–4 times greater than in healthy controls ( Brodtmann et al, 2020 , 2021 ; Salah Khlif et al, 2022 ). Lesioned areas have been shown to lead to further neuronal decay, even in the chronic poststroke stage, with a median rate of 1,590 mm 3 per year ( Seghier et al, 2014b ).…”

Section: Discussionmentioning

confidence: 99%

Structural Neuroplasticity Effects of Singing in Chronic Aphasia

Sihvonen,

Pitkäniemi,

Siponkoski

et al. 2024

eNeuro

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Singing-based treatments of aphasia can improve language outcomes, but the neural benefits of group-based singing in aphasia are unknown. Here, we set out to determine the structural neuroplasticity changes underpinning group-based singing induced treatment effects in chronic aphasia. Twenty-eight patients with at least mild nonfluent post-stroke aphasia were randomized into two groups that received a 4-month multicomponent singing intervention (singing group) or standard care control group). High-resolution T1-images and multi-shell diffusion-weighted MRI data were collected in two time points (baseline / 5-month). Structural grey and white matter neuroplasticity changes were assessed using language network region-of-interest based voxel-based morphometry (VBM) and quantitative anisotropy based connectometry, and their associations to improved language outcomes (WAB Naming and Repetition) were evaluated. Connectometry analyses showed that the singing group enhanced structural white matter connectivity in the left arcuate fasciculus and corpus callosum as well as in the frontal aslant tract, superior longitudinal fasciculus, and corticostriatal tract bilaterally compared to the control group. Moreover, in VBM, the singing group showed grey matter volume increase in the left inferior frontal cortex (BA44) compared to the control group. The neuroplasticity effects in the left BA44, arcuate fasciculus, and frontal aslant tract correlated with improved naming abilities after the intervention. These findings suggest that in post-stroke aphasia group singing can bring about structural neuroplasticity changes in left frontal language areas and in bilateral language pathways, which underpin treatment-induced improvement in speech production.Significance StatementUnderstanding the neural underpinnings of improved language outcomes in aphasia is vital. We utilize longitudinal neuroplasticity measures of both grey and white matter and evaluate their contribution to group-based singing treatment effects in chronic aphasia. The results show that singing intervention induced grey and white matter neuroplasticity changes in the left frontal language-related structures, but also in the right hemisphere (white matter), correlating with improved naming abilities. These results shine light on treatment-induced structural changes in chronic aphasia and improve our understanding of aphasia rehabilitation.

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Cortical thinning 3 years after ischaemic stroke is associated with cognitive impairment and APOE ε4

Cited by 7 publications

References 48 publications

Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke

Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke

Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study

Structural Neuroplasticity Effects of Singing in Chronic Aphasia

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