Cortical thinning in chemotherapy-treated older long-term breast cancer survivors

Daniel, Esther; Deng, Frank; Patel, Sunita K.; Sedrak, Mina S.; Kim, Heeyoung; Razavi, Marianne; Sun, Can‐Lan; Root, James C.; Ahles, Tim A.; Dale, William; Chen, Bihong T.

doi:10.1007/s11682-022-00743-5

Cited by 8 publications

(14 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were no signi cant differences among the groups in age (p = 0.75), education (p = 0.80) or race (p = 0.37) (Table 1). More detailed clinical and demographic information for this cohort has been reported [9]. In the C+ group, 80% of survivors had Stage II breast cancer.…”

Section: Resultsmentioning

confidence: 99%

“…Demographic data At TP1, a total of 60 participants were enrolled with 20 participants for each of the three groups, i.e., C+, C-and HC groups. At TP2, due to attrition from loss to follow-up, new cancer, new memory problems, refusal and death, the cohort consisted of 10 participants for the C+ group, 12 participants for the Cgroup, and 13 participants for HC group [9]. There were no signi cant differences among the groups in age (p = 0.75), education (p = 0.80) or race (p = 0.37) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…NP test performance was analyzed using a generalized linear model (GLM) with the correlation of repeated measurements within subjects [9,41]. Group (C+, C-, HC) and time-point (TP1, TP2) were considered categorical xed effects in this analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Neuroimaging studies have shed light on brain structural and functional alterations underlying CRCI in breast cancer survivors [8][9][10]. Previous studies have found a signi cant reduction in brain gray matter (GM) and white matter in long-term breast cancer survivors at ten or even twenty years after chemotherapy [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…GM atrophy has been known to have a signi cant association with cognitive dysfunction amongst breast cancer survivors [14][15][16][17][18][19][20]. Our previous study of older breast cancer survivors showed cortical thinning in older long-term breast cancer survivors [9].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Altered gyrification in chemotherapy-treated older long-term breast cancer survivors

Daniel

Deng

Patel

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Purpose The purpose of this prospective longitudinal study was to evaluate the changes in brain surface gyrification in older long-term breast cancer survivors 5 to 15 years after chemotherapy treatment. Methods Older breast cancer survivors aged ≥ 65 years treated with chemotherapy (C+) or without chemotherapy (C-) 5–15 years prior and age & sex-matched healthy controls (HC) were recruited (time point 1 (TP1)) and followed up for 2 years (time point 2 (TP2)). Study assessments for both time points included neuropsychological (NP) testing with the NIH Toolbox cognition battery and cortical gyrification analysis based on brain MRI. Results The study cohort with data for both TP1 and TP2 consisted of the following: 10 participants for the C + group, 12 participants for the C- group, and 13 participants for the HC group. The C + group had increased gyrification in 6 local gyrus regions including the right fusiform, paracentral, precuneus, superior, middle temporal gyri and left pars opercularis gyrus, and it had decreased gyrification in 2 local gyrus regions from TP1 to TP2 (p < 0.05, Bonferroni corrected). The C- and HC groups showed decreased gyrification only (p < 0.05, Bonferroni corrected). In C + group, changes in right paracentral gyrification and crystalized composite scores were negatively correlated (R = -0.76, p = 0.01). Conclusions Altered gyrification could be the neural correlate of cognitive changes in older chemotherapy-treated long-term breast cancer survivors.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Altered gyrification in chemotherapy-treated older long-term breast cancer survivors

Daniel

Deng

Patel

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Altered gyrification in chemotherapy‐treated older long‐term breast cancer survivors

Daniel,

Deng,

Patel

et al. 2024

Brain and Behavior

View full text Add to dashboard Cite

PurposeThe purpose of this prospective longitudinal study was to evaluate the changes in brain surface gyrification in older long‐term breast cancer survivors 5–15 years after chemotherapy treatment.MethodsOlder breast cancer survivors aged ≥ 65 years treated with chemotherapy (C+) or without chemotherapy (C‐) 5–15 years prior and age‐ and sex‐matched healthy controls (HC) were recruited (time point 1 (TP1)) and followed up for 2 years (time point 2 (TP2)). Study assessments for both time points included neuropsychological (NP) testing with the NIH Toolbox cognition battery and cortical gyrification analysis based on brain MRI.ResultsThe study cohort with data for both TP1 and TP2 consisted of the following: 10 participants for the C+ group, 12 participants for the C‐ group, and 13 participants for the HC group. The C+ group had increased gyrification in six local gyral regions including the right fusiform, paracentral, precuneus, superior, middle temporal gyri and left pars opercularis gyrus, and it had decreased gyrification in two local gyral regions from TP1 to TP2 (p < .05, Bonferroni corrected). The C‐ and HC groups showed decreased gyrification only (p < .05, Bonferroni corrected). In the C+ group, changes in right paracentral gyrification and crystalized composite scores were negatively correlated (R = –0.76, p = .01).ConclusionsAltered gyrification could be the neural correlate of cognitive changes in older chemotherapy‐treated long‐term breast cancer survivors.

show abstract

Brain white matter microstructural changes in chemotherapy‐treated older long‐term breast cancer survivors

Daniel,

Deng,

Patel

et al. 2023

Cancer Medicine

Self Cite

View full text Add to dashboard Cite

PurposeTo assess white matter microstructural changes in older long‐term breast cancer survivors 5–15 years post‐chemotherapy treatment.MethodsBreast cancer survivors aged 65 years or older who underwent chemotherapy (C+) and who did not undergo chemotherapy (C−) and age‐ and sex‐matched healthy controls (HC) were enrolled at time point 1 (TP1) and followed for 2 years for time point 2 (TP2). All participants underwent brain MRI with diffusion tensor images and neuropsychological (NP) testing with the NIH Toolbox Cognition Battery. Tract‐based spatial statistics (TBSS) analysis was performed on the diffusion tensor images to assess white matter microstructural changes with the fractional anisotropy (FA) parameter.ResultsThere were significant longitudinal alterations in FA within the C+ group over time. The C+ group showed diminished FA in the body and genu of corpus callosum, anterior corona radiate, and external capsule on both the whole brain and region of interest (ROI) based analyses after p < 0.05 family‐wise error (FWE) correction. However, there were no significant group differences between the groups at TP1. Additionally, at TP1, a positive correlation (R = 0.58, p = 0.04) was observed between the FA value of the anterior corona radiata and the crystallized composite score in the C+ group.ConclusionsBrain white matter microstructural alterations may be the underlying neural correlates of cognitive changes in older breast cancer survivors who had chemotherapy treatment years ago.

show abstract

Cortical thinning in chemotherapy-treated older long-term breast cancer survivors

Cited by 8 publications

References 49 publications

Altered gyrification in chemotherapy-treated older long-term breast cancer survivors

Altered gyrification in chemotherapy-treated older long-term breast cancer survivors

Altered gyrification in chemotherapy‐treated older long‐term breast cancer survivors

Brain white matter microstructural changes in chemotherapy‐treated older long‐term breast cancer survivors

Contact Info

Product

Resources

About