Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation

Sato, Keisuke; Fukuda, Masafumi; Sato, Yosuke; Hiraishi, Tetsuya; Takao, Tetsuro; Fujii, Yukihiko

doi:10.1016/j.neulet.2016.07.037

Cited by 4 publications

(5 citation statements)

References 43 publications

(47 reference statements)

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“…Past clinical studies have generally explored applications of fNIRS in nonsurgical settings employing scalp probes. 29,30 Sato et al 14 applied fNIRS intraoperatively to study language system corticocortical networks. Our study demonstrates the intraoperative application of fNIRS for mapping eloquent brain regions validated by DCS.…”

Section: Discussionmentioning

confidence: 99%

“…12 In recent years, fNIRS has advanced significantly and the common scalp probe has evolved into a relatively smaller and higher spatial resolution probe. 13 While fNIRS has been applied intraoperatively to study corticocortical activity in eloquent brain regions 14 and stereotactic functional localization, 11 its nonoperative applications continue to expand [15][16][17][18][19][20][21][22][23][24][25][26][27] and its value in surgical brain mapping remains limited. The present study explores the feasibility of fNIRS for intraoperative functional brain mapping using an enhanced probe and DCS for validation.…”

Section: Introductionmentioning

confidence: 99%

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Functional near-infrared spectroscopy for intraoperative brain mapping

et al. 2019

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Functional near-infrared spectroscopy (fNIRS) is a relatively new seizure-free technique and its value for intraoperative brain mapping is unknown. We examine the feasibility of fNIRS for intraoperative functional brain mapping. A 1 × 1 cm 2 density fNIRS probe specially designed for intraoperative use was used to map brain function in adult patients undergoing awake brain surgery and performing motor and/or language tasks. The ability of fNIRS for functional mapping was compared with direct cortical stimulation (DCS) and regression was used to determine if mean blood pressure (MBP) and blood hemoglobin influenced fNIRS measurements. Eighteen patients underwent awake craniotomy and performed 19 language-and 17 motor-related tasks. fNIRS mapping was highly correlated with DCS for 10 language-and 7 motor-related tasks. fNIRS was able to detect functional language (p < 0.001) and motor areas (p ¼ 0.002). Compared to DCS, fNIRS was less accurate in determining both functional language (at least 22.64%, p < 0.001) and motor areas (at least 32.74%, p < 0.001). Higher MBP and blood hemoglobin were associated with better fNIRS results (p ¼ 0.045 and 0.007, respectively). No seizures or other complications occurred during fNIRS measurement. fNIRS is a promising seizurefree technique for intraoperative brain mapping. The accuracy of current technology needs further development for clinical use.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional near-infrared spectroscopy for intraoperative brain mapping

et al. 2019

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“…Such an approach developed in the operating room could contribute to neurosurgical decisions when typical language eloquent areas must be considered for surgery. 36,37 2.2 What are the Challenges?…”

Section: Characterization Of Language Eloquent Areas and Lateralizati...mentioning

confidence: 99%

“…Direct cortical stimulation of Broca’s area in three children evoked a well-localized typical hemodynamic response in Wernicke’s area via cortico-cortical connectivity. Such an approach developed in the operating room could contribute to neurosurgical decisions when typical language eloquent areas must be considered for surgery 36 , 37 …”

Section: Fnirs and Epilepsy In Pediatric Populationsmentioning

confidence: 99%

Functional near-infrared spectroscopy in pediatric clinical research: Different pathophysiologies and promising clinical applications

2023

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Over its 30 years of existence, functional near-infrared spectroscopy (fNIRS) has matured into a highly versatile tool to study brain function in infants and young children. Its advantages, amongst others, include its ease of application and portability, the option to combine it with electrophysiology, and its relatively good tolerance to movement. As shown by the impressive body of fNIRS literature in the field of cognitive developmental neuroscience, the method's strengths become even more relevant for (very) young individuals who suffer from neurological, behavioral, and/or cognitive impairment. Although a number of studies have been conducted with a clinical perspective, fNIRS cannot yet be considered as a truly clinical tool. The first step has been taken in this direction by studies exploring options in populations with welldefined clinical profiles. To foster further progress, here, we review several of these clinical approaches to identify the challenges and perspectives of fNIRS in the field of developmental disorders. We first outline the contributions of fNIRS in selected areas of pediatric clinical research: epilepsy, communicative and language disorders, and attention-deficit/hyperactivity disorder. We provide a scoping review as a framework to allow the highlighting of specific and general challenges of using fNIRS in pediatric research. We also discuss potential solutions and perspectives on the broader use of fNIRS in the clinical setting. This may be of use to future research, targeting clinical applications of fNIRS in children and adolescents.

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“…Because the NIR-spectrum light attenuation in the skull is relatively low, fNIRS could even facilitate transcranial imaging ( Jobsis, 1977 ; Ferrari and Quaresima, 2012 ; Chiarelli et al, 2017 ; Yücel et al, 2017 ). fNIRS has been used both in an intra-operative ( Fukuda et al, 2015 ; Sato et al, 2016 ; Qiu et al, 2019 ) as well as extra-operative context using a wearable device ( Pinti et al, 2015 ).…”

Section: Metabolism-based Techniquesmentioning

confidence: 99%

Functional imaging of the exposed brain

et al. 2023

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When the brain is exposed, such as after a craniotomy in neurosurgical procedures, we are provided with the unique opportunity for real-time imaging of brain functionality. Real-time functional maps of the exposed brain are vital to ensuring safe and effective navigation during these neurosurgical procedures. However, current neurosurgical practice has yet to fully harness this potential as it pre-dominantly relies on inherently limited techniques such as electrical stimulation to provide functional feedback to guide surgical decision-making. A wealth of especially experimental imaging techniques show unique potential to improve intra-operative decision-making and neurosurgical safety, and as an added bonus, improve our fundamental neuroscientific understanding of human brain function. In this review we compare and contrast close to twenty candidate imaging techniques based on their underlying biological substrate, technical characteristics and ability to meet clinical constraints such as compatibility with surgical workflow. Our review gives insight into the interplay between technical parameters such sampling method, data rate and a technique’s real-time imaging potential in the operating room. By the end of the review, the reader will understand why new, real-time volumetric imaging techniques such as functional Ultrasound (fUS) and functional Photoacoustic Computed Tomography (fPACT) hold great clinical potential for procedures in especially highly eloquent areas, despite the higher data rates involved. Finally, we will highlight the neuroscientific perspective on the exposed brain. While different neurosurgical procedures ask for different functional maps to navigate surgical territories, neuroscience potentially benefits from all these maps. In the surgical context we can uniquely combine healthy volunteer studies, lesion studies and even reversible lesion studies in in the same individual. Ultimately, individual cases will build a greater understanding of human brain function in general, which in turn will improve neurosurgeons’ future navigational efforts.

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Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation

Cited by 4 publications

References 43 publications

Functional near-infrared spectroscopy for intraoperative brain mapping

Functional near-infrared spectroscopy for intraoperative brain mapping

Functional near-infrared spectroscopy in pediatric clinical research: Different pathophysiologies and promising clinical applications

Functional imaging of the exposed brain

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