Cortico-cortical neurones of somesthetic area SI as studied in the cat with fluorescent retrograde double-labelling

Graziosi, M.E.; Tucci, Emily R.; Barbaresi, Paolo; Ugolini, Gabriella; Manzoni, T

doi:10.1016/0304-3940(82)90100-8

Cited by 19 publications

(11 citation statements)

References 11 publications

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“…Nevertheless, the number of neurons bifurcating ipsi-and contralaterally was extremely low, as evidenced by the very small percentage (less than 1%) of double-labeled cells. The fact that callosal and association neurons are different neuronal populations seems to be a general rule: similar results were obtained in the prefrontal (Schwartz and Goldman-Rakic, 1984) and posterior parietal (Andersen et al, 1985) cortices of monkey, in auditory (Wong and Kelly,198 1) and somatosensory (Graziosi et al, 1982) cortices of cat, and in limbic areas (Sarter and Markowitsch, 1985) of rat. An exception to this rule was reported by Segraves and Innocenti (1985) who found that about 15% of the callosal neurons of the suprasylvian area of cat that projected to contralateral areas 17 and 18 also projected to ipsilateral areas 17 and 18.…”

Section: Lack Of Bifurcated Neuronssupporting

confidence: 55%

“…Despite this uniqueness, however, in the moregeneral context of corticocortical connectivity there is no a priori reason to believe that the rules governing callosal and association pathways are different. Anatomical and physiological (Hubel and Wiesel, 1967;Gross and Mishkin, 1977;Innocenti, 1980) studies support a basic similarity between these 2 sets of connections. Developmental considerations point to the same conclusion (Innocenti, 1986 et al., 1975;Kunzle, 1976;Goldman and Nauta, 1977;Rockland and Pandya, 1979;Fitzpatrick and Imig, 1980;Caminiti and Sbriccoli, 1985;see, however, Killackey et al, 1983) and association (Jones et al, 1975;Goldman and Nauta, 1977;WongRiley, 1979;Rockland and Pandya, 1979;Goldman-Rakic and Schwartz, 1982) fibers is stripe-like.…”

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confidence: 93%

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Segregation and overlap of callosal and association neurons in frontal and parietal cortices of primates: a spectral and coherency analysis

et al. 1989

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The spatial relations between selected classes of association and callosal neurons were studied in the frontal and parietal lobes of the macaque monkey using retrogradely transported fluorescent dyes. Fast blue and nuclear yellow were injected in the left frontal (areas 4 and 6) and right posterior parietal (area 5) cortices, respectively. These injections led to the retrograde labeling, in the right frontal cortex, of callosal neurons projecting homotopically and association neurons projecting to ipsilateral area 5; in the left superior parietal lobule, of callosal neurons projecting to contralateral area 5 and association neurons projecting to the ipsilateral frontal lobe. In both frontal and parietal cortices, callosal and association neurons were located in layers III and V-VI; a few neurons were also found in layer II. The contribution of layers V-VI to the callosum was significantly higher in areas 4 and 6 than in area 5. Only a small number of neurons (less than 1%) were double labeled. Spectral analyses were used to characterize the spatial periodicities of the distributions of callosal and association neurons. In areas 4, 6, and 5, both association and callosal spectra were dominated by a strong elevation in the range of low spatial frequencies, corresponding to periodicities in cell density with a peak-to-peak distance of about 8 mm. This indicated an arrangement of these corticocortical cells in the form of bands. The latter displayed various shapes and orientations and were composed of more discrete assemblies of cell clusters of about 400–1000 microns width. Their presence was revealed in the power spectra by a small elevation in the range of high spatial frequencies. The coherency analysis assessed the degree of linear relationships for each spatial frequency, and therefore the degree of similarity, between callosal and association cell distributions, together with their phase relations. Little coherency was found in areas 4 and 6 between bands of callosal and association neurons, which suggests that the 2 cell populations are differently and independently distributed in the tangential domain, with no simple phase relations. The overall mean coherency was higher in area 5 than in the frontal cortex: callosal and association bands were more similar in shape, with more extensive zones of overlap. These data indicate that callosal and association neurons share common principles of spatial organization despite the great regional variability of their interrelations in the tangential cortical domain.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Lack Of Bifurcated Neuronssupporting

confidence: 55%

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confidence: 93%

Segregation and overlap of callosal and association neurons in frontal and parietal cortices of primates: a spectral and coherency analysis

et al. 1989

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“…In cats, the laminar pattern of the SI to SII projection is not of the feedforward type, since it originates from neurons not only in supragranular Alloway and Burton, 1985;Barbaresi et al, 1987) but also in infragranular layers (Graziosi et al, 1982;Manzoni et al, 19901, and, as shown by the present experiments, the majority of its axon terminals are concentrated in supragranular layers, while very few are in layer IV. In this species the suppression of the input from ipsilateral SI leaves the peripheral reactivity of SII neurons substantially unaltered Burton and Robinson, 1987; Burton et al, 1988;Turman et al, 1992).…”

Section: The Laminar Pattern Of the Si To Sii Projection Of Cats Is Nmentioning

confidence: 70%

Topographical relations between ipsilateral cortical afferents and callosal neurons in the second somatic sensory area of cats

Barbaresi

Minelli

Manzoni

1994

J of Comparative Neurology

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Experiments were carried out on the second somatic sensory area (SII) of cats to study 1) the laminar distribution of axon terminals from the ipsilateral first somatic sensory cortex (SI); and 2) the topographical relations between their terminal field and the callosal neurons projecting to the contralateral homotopic cortex. To label simultaneously in SII both ipsilateral cortical afferents and callosal cells, cats were given iontophoretic injections of Phaseolus vulgaris-leucoagglutinin (PHA-L) in the forepaw zone of ipsilateral SI, and pressure injections of horseradish peroxidase (HRP) in the same zone of contralateral SII. The possibility that ipsilateral cortical axon terminals synapse callosal neurons was investigated with the electron microscope by combining lesion-induced degeneration with retrograde HRP labelling. Fibers and terminations immunolabelled with PHA-L from ipsilateral SI were distributed in SII in a typical patchy pattern and were mostly concentrated in supragranular layers. Labelled fibers formed a very dense plexus in layer III and ramified densely also in layers I and II. Labelled axon terminals were both en passant and single-stalked boutons. Counts of 8,303 PHA-L-labelled terminals of either type showed that 82.40% were in supragranular layers. The highest concentration was in layer III (43.99%), followed by layers II (30.32%) and I (8.09%). The remaining terminals were distributed among layers IV (6.96%), V (4.93%), and VI (5.68%). The same region of SII containing anterogradely labelled axons and terminals also contained numerous neurons retrogradely labelled with HRP from contralateral SII. Callosal projection neurons were pyramidal, dwelt mainly in layer III, and were distributed tangentially in periodic patches. Patches of anterograde and retrograde labelling either interdigitated or overlapped both areally and laminarly. In the zones of overlap, numerous PHA-L-labelled axon terminals were seen in close apposition to HRP-labelled pyramidal cell dendrites. Combined HRP-electron microscopic degeneration experiments showed that in SII axon terminals from ipsilateral SI form asymmetric synapses with HRP-labelled dendrites and dendritic spines pertaining to callosal projection neurons. These results are discussed in relation to the layering and function of the SI to SII projection, and to the evidence that SII neurons projecting to the homotopic area of the contralateral hemisphere have direct access to the sensory information transmitted from ipsilateral SI.

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“…Ipsilateral Reciprocal. In cats there are reciprocal and homotopic connections between SI and ipsilateral SII Uones and Powell, 1968b;Graziosi et at., 1982;Burton and Kopf, 1984b;Alloway and Burton, 1985;reviewed in Barbaresi et at., 1987). Cells of origin of SI-to-SII fibers are mostly pyramidal cells in layer 3 (Burton and Kopf, 1984b;90%, Barbaresi et at., 1987), most in the outer part of the layer, with a few cells in layers 2, 5, and 6 and least in 4 and upper 5 Graziosi et at., 1982).…”

mentioning

confidence: 99%

Comparative Development of Somatic Sensory Cortex

Johnson

1990

Cerebral Cortex

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Cortico-cortical neurones of somesthetic area SI as studied in the cat with fluorescent retrograde double-labelling

Cited by 19 publications

References 11 publications

Segregation and overlap of callosal and association neurons in frontal and parietal cortices of primates: a spectral and coherency analysis

Segregation and overlap of callosal and association neurons in frontal and parietal cortices of primates: a spectral and coherency analysis

Topographical relations between ipsilateral cortical afferents and callosal neurons in the second somatic sensory area of cats

Comparative Development of Somatic Sensory Cortex

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