Cortico-subcortical functional connectivity profiles of resting-state networks in marmosets and humans

Hori, Yuki; Schaeffer, David J.; Yoshida, Atsushi; Cléry, Justine; Hayrynen, Lauren K.; Gati, Joseph S.; Menon, Ravi S.; Everling, Stefan

doi:10.1101/2020.07.14.202382

Cited by 10 publications

(16 citation statements)

References 71 publications

(34 reference statements)

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“…2 for all derived network maps). Seven statistically significant networks were found: three somatosensory networks (SMNs), a default mode network (DMN), a primary visual network (VISp), a high-order visual network (VISh), and a salience network (SAN)-networks previously confirmed to be present in the resting marmoset 28,37,48 . Inter-brain synchronous connectivity with a visible conspecific.…”

Section: Resultsmentioning

confidence: 94%

Simultaneous functional MRI of two awake marmosets

et al. 2021

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Social cognition is a dynamic process that requires the perception and integration of a complex set of idiosyncratic features between interacting conspecifics. Here we present a method for simultaneously measuring the whole-brain activation of two socially interacting marmoset monkeys using functional magnetic resonance imaging. MRI hardware (a radiofrequency coil and peripheral devices) and image-processing pipelines were developed to assess brain responses to socialization, both on an intra-brain and inter-brain level. Notably, the brain activation of a marmoset when viewing a second marmoset in-person versus when viewing a pre-recorded video of the same marmoset—i.e., when either capable or incapable of socially interacting with a visible conspecific—demonstrates increased activation in the face-patch network. This method enables a wide range of possibilities for potentially studying social function and dysfunction in a non-human primate model.

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Section: Resultsmentioning

confidence: 94%

Simultaneous functional MRI of two awake marmosets

et al. 2021

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“…frontal eye field, LIP) even under resting-state (Fox et al, 2005). In marmosets, one of the core regions of the DMN is the cortex surrounding the IPS (Belcher et al, 2013; Hori et al, 2020b; Liu et al, 2019). A functional imaging study in marmosets showed that these areas were deactivated during a visual stimulation task relative to the period when a black screen was presented (Liu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…A functional imaging study in marmosets showed that these areas were deactivated during a visual stimulation task relative to the period when a black screen was presented (Liu et al, 2019). On the other hand, the area surrounding the marmoset IPS have also been linked to the attention-like frontoparietal network by several RS-fMRI studies (Ghahremani et al, 2016;Hori et al, 2020b). It is also known that electrical microstimulation in the areas surrounding the IPS evoke saccadic eye movements (Ghahremani et al, 2019) and that single neurons in the region show neural correlates for the gap effect in saccadic eye movement tasks (Ma et al, 2020).…”

Section: Functional Correspondence In Parietal and Motion-selective Vmentioning

confidence: 99%

“…Functional magnetic resonance imaging (fMRI) plays an important role in identifying the functional architecture of marmoset cortex (Belcher et al, 2013;Hori et al, 2020a;Schaeffer et al, 2019c) and in establishing brain homologies between primate species (Ghahremani et al, 2016;Hori et al, 2020b;Schaeffer et al, 2019c). In particular resting-state fMRI has been used (i) to identify homologous large-scale brain networks between marmosets and humans (Ghahremani et al, 2016;Hori et al, 2020a;Schaeffer et al, 2019c), (ii) to define functional boundaries based on intrinsic functional connectivity (Schaeffer et al, 2019b(Schaeffer et al, , 2019a, and (iii) to use functional connectivity "fingerprints" of brain areas to establish homologies between marmosets, rodents, and humans (Schaeffer et al, 2020a).…”

Section: Introductionmentioning

confidence: 99%

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Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas

Hori

Cléry

Schaeffer

et al. 2021

Preprint

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The common marmoset has enormous promise as a nonhuman primate model of human brain functions. While resting-state functional magnetic resonance imaging (fMRI) has provided evidence for a similar organization of marmoset and human cortices, the technique cannot be used to map the functional correspondences of brain regions between species. This limitation can be overcome by movie-driven fMRI (md-fMRI), which has become a popular tool for non-invasively mapping the neural patterns generated by rich and naturalistic stimulation. Here, we used md-fMRI in marmosets and humans to identify whole-brain functional correspondences between the two primate species. In particular, we describe functional correlates for the well-known human face, body, and scene patches in marmosets. We find that these networks have a similar organization in both species, suggesting a largely conserved organization of higher-order visual areas between New World marmoset monkeys and humans. However, while face patches in humans and marmosets were activated by marmoset faces, only human face patches responded to the faces of other animals. Together, the results demonstrate that md-fMRI is a powerful tool for interspecies functional mapping and characterization of higher-order visual functions.

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“…However, strong overlaps in SI connectivity maps were found in pulvinar and VP suggesting that parts of these areas process tactile information regardless of the stimulated body part. VP has been shown to be strongly connected to 3a and 3b (Brysch et al, 1990;Krubitzer and Kaas, 1992;Huffman and Krubitzer, 2001b;Hori et al, 2020b). SII connectivity maps showed mainly overlap between body representations.…”

Section: Somatotopy In Subcortical Areas: Thalamus and Putamenmentioning

confidence: 95%

Whole brain mapping of somatosensory responses in awake marmosets investigated with ultra-high-field fMRI

Cléry

Hori

Schaeffer

et al. 2020

Journal of Neurophysiology

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The common marmoset (Callithrix jacchus) is a small-bodied New World primate that is becoming an important model to study brain functions. Despite several studies exploring the somatosensory system of marmosets, all results have come from anesthetized animals using invasive techniques and post-mortem analyses. Here we demonstrate the feasibility for getting high-quality and reproduceable somatosensory mapping in awake marmosets with functional magnetic resonance imaging (fMRI). We acquired fMRI sequences in four animals while they received tactile stimulation (via air-puffs), delivered to the face, arm or leg. We found a topographic body representation with the leg representation in the most medial part, the face representation in the most lateral part, and the arm representation between leg and face representation within areas 3a, 3b, 1/2. A similar sequence from leg to face from caudal to rostral sites was identified in areas S2 and PV. By generating functional connectivity maps of seeds defined in the primary and second somatosensory regions, we identified two clusters of tactile representation within the posterior and midcingulate cortex. However, unlike humans and macaques, no clear somatotopic maps were observed. We found a somatotopic body representation in the thalamus and, for the first time in marmosets, in the putamen. These maps have similar organizations as those previously found in Old World macaque monkeys and humans, suggesting that these subcortical somatotopic organizations were already established before Old and New World primates diverged. Our results show the first whole brain mapping of somatosensory responses acquired in a non-invasive way in awake marmosets.

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Cortico-subcortical functional connectivity profiles of resting-state networks in marmosets and humans

Cited by 10 publications

References 71 publications

Simultaneous functional MRI of two awake marmosets

Simultaneous functional MRI of two awake marmosets

Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas

Whole brain mapping of somatosensory responses in awake marmosets investigated with ultra-high-field fMRI

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