Corticomotor excitability is altered in central neuropathic pain compared with non-neuropathic pain or pain-free patients

Neuroplasticity in the pathogenesis and treatment of chronic pain syndrome: new research and therapeutic perspectives

“…This includes discussing different types of chronic pain related to Parkinson's disease, central neuropathic pain, phantom limb pain, the use of TENS interventions, chronic low back pain, and exploring the correlation between BDNF levels and clinical pain assessments in older individuals with knee osteoarthritis. It also covers the role of neuroplasticity and neurotrophins in chronic pain, along with the association between sensory and motor cortex characteristics and chronic low back pain [21][22][23][24][25][26][27]. The third group, "Neural Circuits and Pathways," focuses on the involvement of neural circuits and pathways in chronic pain, including contemporary pain science theories, biological underpinnings, and underlying neural pathways [28][29][30][31][32].…”

“…The second subcategory, "Neuroplasticity in Pain Modulation," focuses on adaptive changes in neural pathways related to the perception and regulation of pain [14,[23][24][25]30,31]. Lastly, "Cortical Plasticity in Chronic Pain" is the third subcategory, specifically addressing changes in cortical regions associated with chronic pain conditions [9,15,[19][20][21][22]26,27,32]. The references cited in each subcategory correspond to the studies or sources that have investigated or discussed these neuroplastic mechanisms.…”

“…The group titled "Bidirectional Relationship Between Chronic Pain and Neuroplasticity" (Frequency: 11) delves into studies exploring the reciprocal influence between chronic pain and neuroplasticity, suggesting a feedback loop wherein chronic pain induces neuroplastic changes while neuroplasticity mechanisms can exacerbate pain experiences [9,13,15,18,[23][24][25][28][29][30]32]. Additionally, the "Impact of Neuroplasticity on Chronic Pain" group (Frequency: 5) concentrates on how neuroplasticity mechanisms directly affect chronic pain, implying their crucial role in pain development and maintenance [16,21,26,33,34]. The "Neuroplasticity Modulation Techniques in Chronic Pain" category (Frequency: 3) examines interventions targeting neuroplasticity to alleviate chronic pain symptoms [17,18,24].…”

Neuroplastic Responses After Prolonged Experimental Pain and Multifocal Transcranial Direct Current Stimulation

“…This type of altered responses are found in patients with chronic neuropathic profiles with e.g. impaired CPM 72,73 , abnormal glutamatergic levels in the anterior cingulate cortex (ACC) 74,75 , altered resting-state functional connectivity in the default-mode networks 76 , reduced peak alpha frequency (PAF) 77 and, as compared with non-neuropathic patients and healthy controls, reduced ICI 78 and MEPs 73,79 .…”