Corticospinal tract-sparing intensity-modulated radiotherapy treatment planning

Igaki, Hiroshi; Sakumi, A.; Mukasa, Akitake; Kunimatsu, Akira; Masutani, Yoshitaka; Hanakita, Shunya; Ino, Kenji; Haga, Akihiro; Nakagawa, Keiichi; Ohtomo, Kuni

doi:10.1016/j.rpor.2014.01.002

Cited by 11 publications

(11 citation statements)

References 52 publications

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“…The authors found that the maximum and mean dose (Dmax and Dmean) to the ipsilateral and contralateral PMC and CST regions were considerably decreased in the IMRT plans, including tractography and fMRI data, possibly reducing the probability of late radiation injury to these structures [ 85 ]. Similar results of dose-reduction to relevant white matter tracts located near the RT target volumes were described in another study from Igaki et al, which incorporated the CST as OAR in the IMRT plan of GBM and comparing the dose sparing with respect to conventional IMRT [ 86 ].…”

Section: Advanced Physiological Mri For Rt Planning Of Gliomas: Tesupporting

confidence: 65%

Advanced Imaging Techniques for Radiotherapy Planning of Gliomas

Castellano

Bailo

Cicone

et al. 2021

Cancers

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The accuracy of target delineation in radiation treatment (RT) planning of cerebral gliomas is crucial to achieve high tumor control, while minimizing treatment-related toxicity. Conventional magnetic resonance imaging (MRI), including contrast-enhanced T1-weighted and fluid-attenuated inversion recovery (FLAIR) sequences, represents the current standard imaging modality for target volume delineation of gliomas. However, conventional sequences have limited capability to discriminate treatment-related changes from viable tumors, owing to the low specificity of increased blood-brain barrier permeability and peritumoral edema. Advanced physiology-based MRI techniques, such as MR spectroscopy, diffusion MRI and perfusion MRI, have been developed for the biological characterization of gliomas and may circumvent these limitations, providing additional metabolic, structural, and hemodynamic information for treatment planning and monitoring. Radionuclide imaging techniques, such as positron emission tomography (PET) with amino acid radiopharmaceuticals, are also increasingly used in the workup of primary brain tumors, and their integration in RT planning is being evaluated in specialized centers. This review focuses on the basic principles and clinical results of advanced MRI and PET imaging techniques that have promise as a complement to RT planning of gliomas.

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Section: Advanced Physiological Mri For Rt Planning Of Gliomas: Tesupporting

confidence: 65%

Advanced Imaging Techniques for Radiotherapy Planning of Gliomas

Castellano

Bailo

Cicone

et al. 2021

Cancers

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“…Table 2 summarises the study characteristics of 19 eligible articles. Based on the quantitative MRI techniques used to guide RT planning, included studies were classified as follows: DWI and PWI [24] , [25] , [26] , [27] , [28] ; DTI [29] , [30] , [31] , [32] , [33] , [34] , [35] ; and MRSI [36] , [37] , [38] , [39] , [40] , [41] , [42] . …”

Section: Resultsmentioning

confidence: 99%

The role and potential of using quantitative MRI biomarkers for imaging guidance in brain cancer radiotherapy treatment planning: A systematic review

Aldawsari,

Al-Qaisieh,

Broadbent

et al. 2023

Physics and Imaging in Radiation Oncology

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“…Further research delineating contouring of the corticospinal tract as an organ at risk could be useful for similar concerning cases, and further study is certainly warranted. 16 There have been several trials in pediatric brainstem glioma patients in which primary radiotherapy exceeded 70 Gy. Although a limitation of all these trials was that poor survival did not afford the assessment of long-term complications, the two trials that provided the highest BED 3 are as follows.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Metachronous medulloblastoma and glioblastoma: Implications for clinical and technical aspects of re-irradiation

Verma

Kulkarni

Bhirud

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Glioblastoma Re-irradiation Brainstem tolerance Toxicity a b s t r a c tA seven-year-old male underwent surgical resection and chemoradiation for average risk medulloblastoma; twelve years later, the presence of a necrotic and infiltrative mass in the same area and invading the brainstem prompted a subtotal resection. Pathology was indicative of glioblastoma. He was then treated with concurrent temozolomide and using biologically effective dose calculations for gross residual tumor tissue in the brainstem as well as brainstem tolerance, a radiotherapy dose of 3750 cGy was chosen, fractionated in twice-daily fractions of 125 cGy each. The gross tumor volume was expanded with a 5 mm margin to the planning target volume, which was also judiciously subtracted from the normal brainstem. He completed his radiotherapy course with subsequent imaging free of residual tumor and continued adjuvant temozolomide and remains under followup surveillance. This case underscores the rarity of metachronous medulloblastoma and glioblastoma, of which only five known cases heretofore have been described. We discuss the technicalities of radiotherapy planning in this patient, including common hurdles for radiation oncologists in similar patients. BackgroundMetachronous brain tumors are defined as the development of at least two histologically distinct primary intracranial neoplasms, not related to local recurrence of the initial tumor. novo tumor. 1 Sometimes, the development of a second primary brain tumor is a result of previous radiation, especially in pediatric patients. 2,3 The presence of certain risk factors, such as familial cancer syndromes, may increase the chance of developing secondary neoplasms after radiotherapy. 4 While many radiation-induced intracranial neoplasms have been reported within fifteen years of radiotherapy, 2,3 http://dx

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Corticospinal tract-sparing intensity-modulated radiotherapy treatment planning

Abstract: IMRT plans with diminished doses to the corticospinal tract were attained. This technique enabled us to spare specific neuron fibers as OARs which were formerly "invisible" and to reduce the probability of late morbidities.

Cited by 11 publications

References 52 publications

Advanced Imaging Techniques for Radiotherapy Planning of Gliomas

Advanced Imaging Techniques for Radiotherapy Planning of Gliomas

The role and potential of using quantitative MRI biomarkers for imaging guidance in brain cancer radiotherapy treatment planning: A systematic review

Metachronous medulloblastoma and glioblastoma: Implications for clinical and technical aspects of re-irradiation

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