Corticosteroid and tamoxifen therapy in sclerosing encapsulating peritonitis in a patient on continuous ambulatory peritoneal dialysis

Evrenkaya, T. Rıfkı; Atasoyu, Enes Murat; Ünver, Suat; Başekim, C. Çınar; Baloğlu, Hüseyi̇n; Tülbek, M. Yaşar

doi:10.1093/ndt/gfh150

Cited by 33 publications

(19 citation statements)

References 9 publications

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“…[6] In the literature, three authors have described using tamoxifen and steroids in the treatment of EPS. [8][9][10] The first case of EPS treated with tamoxifen alone was reported by Turner et al [7] A few other case reports have also reported success using this drug. [3,6,7] Others have advocated empirical treatment of tamoxifen to prevent the development of EPS in those patients with high risk factors (long-term [i.e., > 5 years] PD, those with high transporter status, loss of ultrafiltration or radiological changes [4] ), but this requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Encapsulating Peritoneal Sclerosis Presenting with Recurrent Ascites and Tamoxifen: Case Reports and Review of the Literature

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Encapsulating Peritoneal Sclerosis Presenting with Recurrent Ascites and Tamoxifen: Case Reports and Review of the Literature

et al. 2007

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“…Since then several case series have been published reporting its successful use in EPS. [1314] Treatment with tamoxifen and steroid was found to improve survival compared to steroid monotherapy alone. [15]…”

Section: Discussionmentioning

confidence: 99%

Combined surgical and immunosupressive therapy for encapsulating peritoneal sclerosis

Bipi¹,

Gracious²,

Kumar³

et al. 2016

Indian J Nephrol

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Encapsulating peritoneal sclerosis (EPS) is an infrequent but serious complication of long-term peritoneal dialysis with 50% mortality and lack consensus on treatment. The pathogenesis of EPS is ill understood, and diagnosis lacks specificity and relies on clinical, radiographic and microscopic evaluation. Since there is no general agreement on managing EPS, we report a case treated successfully with surgery followed by immunosuppressive therapy with tamoxifen and steroids. He later successfully underwent deceased donor renal transplantation.

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“…11 Use of tamoxifen plus corticosteroids has also been reported in the literature. [12][13][14] In a series of 23 patients with peritoneal sclerosis, none of the 9 patients who received tamoxifen developed EPS, but 4 of the 14 patients who were not receiving tamoxifen treatment developed EPS. 15 …”

Section: Discussionmentioning

confidence: 99%

Additive Effectiveness of Everolimus Plus Tamoxifen Therapy in Treatment of Encapsulating Peritoneal Sclerosis

Huddam¹,

Azak²,

Koçak³

et al. 2012

Renal Failure

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Peritoneal dialysis (PD) is one of the commonly used choices of continuous renal replacement therapies. Peritoneal membrane is damaged by using solutions with lower biocompatibility, peritonitis episodes, and vintage of PD therapy. Encapsulating peritoneal sclerosis (EPS) is a rare complication of PD and is presented by progressive fibrosis of the peritoneum. Fibrous tissue entrapment of the intestine, leading to complete intestinal obstruction, is referred to as EPS, the most severe form of sclerosing peritonitis. EPS is irreversible fibrosis of the peritoneal membrane usually associated with high rates of morbidity and mortality. Preventive strategies are the best choice of treatment. Also there is no proven effective therapy for EPS; there are only small-sized trials. Herein we present a case of EPS who improved with everolimus plus tamoxifen therapy.

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Corticosteroid and tamoxifen therapy in sclerosing encapsulating peritonitis in a patient on continuous ambulatory peritoneal dialysis

Cited by 33 publications

References 9 publications

Encapsulating Peritoneal Sclerosis Presenting with Recurrent Ascites and Tamoxifen: Case Reports and Review of the Literature

Encapsulating Peritoneal Sclerosis Presenting with Recurrent Ascites and Tamoxifen: Case Reports and Review of the Literature

Combined surgical and immunosupressive therapy for encapsulating peritoneal sclerosis

Additive Effectiveness of Everolimus Plus Tamoxifen Therapy in Treatment of Encapsulating Peritoneal Sclerosis

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