Corticosteroid-Associated Tendinopathies

Blanco, Irene; Krähenbühl, Stephan; Schlienger, Raymond G.

doi:10.2165/00002018-200528070-00005

Cited by 51 publications

(16 citation statements)

References 84 publications

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“…Although the use of corticosteroids and fluorquinolones has been identified as a risk factor for developing tendinopathy [ 14 , 15 ], in this study only few patients were treated with corticosteroids or fluoroquinolones before the start of the symptoms, so we could not draw conclusions on the association between the use of these medications and tendinopathy. The percentage of tendinopathy patients using statins was not significantly different from the percentage of people using antilipaemic drugs in the total practice population.…”

Section: Discussionmentioning

confidence: 91%

“…In previous studies, several factors have been investigated for a possible association with the development of tendinopathy. Aside from increasing age [ 11 , 12 ], gender differences [ 13 ], and use of medication (corticosteroids, fluoroquinolones, and statins) [ 14 – 16 ], co-morbidities that have been linked to tendinopathy are hypertension, dyslipidaemia, and diabetes mellitus [ 17 ]. The secondary aim of this study was to investigate whether in this general practice population an association between tendinopathy and gender, age, use of medication, or co-morbidities could be found.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study

Albers

Zwerver

Diercks

et al. 2016

BMC Musculoskelet Disord

229

152

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BackgroundLower extremity tendinopathy is a common sports injury, but it can also affect non-athletes. Because tendinopathy is difficult to treat and has negative effects on the ability to work and quality of life, development of preventive interventions is important. The first step in the Van Mechelen prevention model is to determine the extent of the problem. The primary aim of this study was to determine the incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population. The secondary aim was to investigate possible associated factors.MethodsA cross-sectional study was performed in a Dutch general practice. Using International Classification of Primary Care codes, the electronic patient files were searched to identify cases of adductor tendinopathy, greater trochanteric pain syndrome, jumper’s knee, Achilles tendinopathy, and plantar fasciopathy in 2012. The tendinopathy patients were compared to the general practice population regarding age, gender, use of medication, and comorbidity using 95 % confidence intervals.ResultsThe prevalence and incidence rates of lower extremity tendinopathy found in this study were 11.83 and 10.52 per 1000 person-years. Lower extremity tendinopathy was more prevalent among older patients. No differences between tendinopathy patients and the general practice population were found regarding gender, use of medication, or comorbidity.ConclusionsIn this cross-sectional study in a Dutch general practice, the prevalence and incidence rates of lower extremity tendinopathy were 11.83 and 10.52 per 1000 person-years. Lower extremity tendinopathy deserves a higher place in locomotor system research to develop preventive interventions.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study

Albers

Zwerver

Diercks

et al. 2016

BMC Musculoskelet Disord

229

152

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“…Numerous published case studies and pharmacovigilance databases report tendon ruptures in association with corticosteroid use (25). A recent case-control database study of 8000 cases and 33,000 controls found that oral but not inhaled corticosteroids increase risk of Achilles and biceps tendon rupture (26).…”

Section: Exogenous Oral Glucocorticoids and Their Effects On Tendonmentioning

confidence: 99%

Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy?

Lewis

Zeisig

Gaida

2020

Endocrine Connections

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Background While metabolic health is acknowledged to affect connective tissue structure and function, the mechanisms are unclear. Glucocorticoids are present in almost every cell type throughout the body and control key physiological processes such as energy homeostasis, stress response, inflammatory and immune processes, and cardiovascular function. Glucocorticoid excess manifests as visceral adiposity, dyslipidemia, insulin resistance, and type 2 diabetes. As these metabolic states are also associated with tendinopathy and tendon rupture, it may be that glucocorticoids excess is the link between metabolic health and tendinopathy. Objective To synthesise current knowledge linking glucocorticoid exposure to tendon structure and function. Methods Narrative literature review. Results We provide an overview of endogenous glucocorticoid production, regulation, and signalling. Next we review the impact that oral glucocorticoid has on risk of tendon rupture and the effect that injected glucocorticoid has on resolution of symptoms. Then we highlight the clinical and mechanistic overlap between tendinopathy and glucocorticoid excess in the areas of visceral adiposity, dyslipidemia, insulin resistance and type 2 diabetes. In these areas, we highlight the role of glucocorticoids and how these hormones might underpin the connection between metabolic health and tendon dysfunction. Conclusions There are several plausible pathways through which glucocorticoids might mediate the connection between metabolic health and tendinopathy.

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“…For inclusion, subjects must have been at least 18 years of age and categorized as at least moderately active on the International Physical Activity Questionnaire Short Form (IPAQ-SF; Figure 1), as well as having a lifetime absence of pain or discomfort in either Achilles tendon. A health-history form was also required to screen for exclusion criteria that included history of Achilles tendon pain of any duration or at any point in time, corticosteroid injection to the area of the Achilles tendon, 19 fluoroquinolone use, 20 surgery or rupture of the Achilles tendon, or neurologic conditions affecting the lower extremity. The recruitment materials clearly defined these criteria, and 9 volunteers were excluded from the study.…”

Section: Participantsmentioning

confidence: 99%

Incidence of Morphologic Changes in Asymptomatic Achilles Tendons in an Active Young Adult Population

Joseph

Trojian²,

Anderson³

et al. 2013

Journal of Sport Rehabilitation

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Corticosteroid-Associated Tendinopathies

Cited by 51 publications

References 84 publications

Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study

Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study

Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy?

Incidence of Morphologic Changes in Asymptomatic Achilles Tendons in an Active Young Adult Population

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