Corticosteroid-binding globulin

Westphal, Ulrich

doi:10.1007/bf00673709

Cited by 24 publications

(11 citation statements)

References 31 publications

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“…Altering glucocorticoid and CBG levels can be synergistic, since increasing glucocorticoid levels can reduce CBG levels (26,68), thereby greatly augmenting glucocorticoid availability to target tissues. Furthermore, CBG binding is saturated at near-basal glucocorticoid levels (75); therefore, small rises in glucocorticoid concentrations result in large increases in free hormone available to receptors (21). Consequently, the increase in CBG capacity during July in the lemmings could act as a buffer to limit corticosterone availability to receptors.…”

Section: Discussionmentioning

confidence: 98%

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Seasonal glucocorticoid responses to capture in wild free-living mammals

Romero¹,

Meister²,

Cyr³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

109

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We determined baseline and capture-induced glucocorticoid concentrations during two different seasons in three species of wild free-living rodents: brown lemmings (Lemmus trimucronatus), golden-mantled ground squirrels (Spermophilus saturatus), and yellow-pine chipmunks (Tamias amoenus). Initial blood samples were obtained within 3 min of capture, so that initial glucocorticoid levels reflect baseline titers of undisturbed animals. Animals were held for an additional 30 min, when a second blood sample was taken to measure stress-induced glucocorticoid titers. The primary glucocorticoid differed in each species. Lemmings secreted extremely large amounts of corticosterone (as high as 8,000 ng/ml). These high concentrations were accompanied by high corticosterone-binding globulin capacity and resistance to negative feedback. Squirrels and chipmunks secreted a mixture of cortisol and corticosterone (10-400 ng/ml). In males of all three species and female squirrels and chipmunks, glucocorticoid levels were significantly elevated 30 min after capture. Baseline and 30-min glucocorticoid levels differed seasonally in each species. Levels were higher during summer (with no snow cover) than in spring (with approximately 60% snow cover) in female lemmings, higher during breeding than before hibernation in squirrels, and higher postreproductively than during breeding in chipmunks. Together, these data indicate that glucocorticoid responses to stress in these free-living species are similar to those in laboratory species, but the magnitude of the response appears to depend on life-history features specific to each species.

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Section: Discussionmentioning

confidence: 98%

“…The first is through CBG binding (75). Only free glucocorticoids are believed to be available to tissues (60), although this is under some debate (56).…”

Section: Discussionmentioning

confidence: 99%

Seasonal glucocorticoid responses to capture in wild free-living mammals

Romero¹,

Meister²,

Cyr³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

109

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“…Corticosteroid binding globulin (CBG) is a glycoprotein produced in liver. It has a relatively high binding affinity for corticosteroids and as a result, most corticosteroids in the circulation are found bound to CBG (Westphal, 1983). Only free unbound hormone is available for binding the intracellular receptor or subject to hepatic degradation (Rosner, 1990).…”

Section: Gonadal Steroid Control Of the Hpa Axismentioning

confidence: 99%

Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis

Handa

Weiser

2014

Frontiers in Neuroendocrinology

342

282

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The hypothalamo-pituitary-adrenal (HPA) axis represents a complex neuroendocrine feedback loop controlling the secretion of adrenal glucocorticoid hormones. Central to its function is the paraventricular nucleus of the hypothalamus (PVN) where neurons expressing corticotropin releasing factor reside. These HPA motor neurons are a primary site of integration leading to graded endocrine responses to physical and psychological stressors. An important regulatory factor that must be considered, prior to generating an appropriate response is the animal’s reproductive status. Thus, PVN neurons express androgen and estrogen receptors and receive input from sites that also express these receptors. Consequently, changes in reproduction and gonadal steroid levels modulate the stress response and this underlies sex differences in HPA axis function. This review examines the make up of the HPA axis and hypothalamopituitary-gonadal (HPG) axis and the interactions between the two that should be considered when exploring normal and pathological responses to environmental stressors.

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“…This accelerated secretion is under hypothalamic control [re view in ref. 5], as has been recently confirmed [1], It is well known that the unbound frac tion of the steroid is of physiological signifi cance as it acts upon target organs [23]. Our present work is an attempt to give informa tion on the following points: (l)The hor monal levels and pituitary control of total and unbound plasma corticosterone concen trations in fetal rat plasma during late preg nancy.…”

mentioning

confidence: 92%

Effect of Fetal Decapitation on Unbound Rat Plasma Corticosterone Concentration at the End of Pregnancy

Cohen¹,

Guillon²

1985

Neonatology

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In normal fetuses from day 16 to 21 of pregnancy, unbound plasma corticosterone concentration increases slowly from day 16 to 17, and rapidly from day 17 to 19, remaining high until birth. Fetal decapitation on day 18 produces a fall in unbound plasma corticosterone only when the mother is adrenalectomized. The ability of corticosterone to cross the placental barrier from mother to fetus or inversely is discussed.

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Corticosteroid-binding globulin

Cited by 24 publications

References 31 publications

Seasonal glucocorticoid responses to capture in wild free-living mammals

Seasonal glucocorticoid responses to capture in wild free-living mammals

Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis

Effect of Fetal Decapitation on Unbound Rat Plasma Corticosterone Concentration at the End of Pregnancy

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