Corticosteroid-induced cataracts

Urban, Robert C.; Cotlier, Edward

doi:10.1016/0039-6257(86)90077-9

Cited by 310 publications

(122 citation statements)

References 69 publications

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“…101,102 The incidence also depends on the individual's age (particularly in children) and ethnic origin, with Hispanic people being more susceptible to development of PSCs. 101 However, the evidence of an association between ICS use and development of a PSC is equivocal and often confounded by previous exposure to oral corticosteroid therapy. Three studies have reported no association between long-term low-and high-dose ICS therapy in adults and the prevalence of PSCs.…”

mentioning

confidence: 99%

Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over

Shepherd¹,

Rogers²,

Anderson³

et al. 2008

Health Technol Assess

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mentioning

confidence: 99%

Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over

Shepherd¹,

Rogers²,

Anderson³

et al. 2008

Health Technol Assess

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“…For systemic corticosteroids, the increased risk for the development of posterior subcapsular cataract is well established [27,28]. Despite anecdotal reports [29,30] suggesting an increased risk of cataracts also with the use of ICSs, studies specifically designed to investigate the association between ICS use and the risk of developing cataract failed to find significant relationships [31][32][33].…”

Section: Cataractmentioning

confidence: 99%

Erratum to: Safety Considerations of Inhaled Corticosteroids in the Elderly

et al. 2015

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Inhaled corticosteroids (ICSs) are widely used in the treatment of patients with chronic obstructive pulmonary diseases. However, high-dose regimens and longterm use of ICSs have the potential to cause a variety of local and systemic side effects such as candidiasis, cataracts, glaucoma, and osteoporosis. The use of ICSs can also be associated with the risk of bone fractures, diabetes mellitus and pneumonia. These ICS-related side effects are of particular importance in elderly patients due to the presence of comorbidities and age-related behavioral, cognitive, and psychological problems, which can all interact with inhaled treatment. We reviewed the available literature on the clinically relevant side effects of ICSs in the elderly to provide practical measures to properly monitor and manage the risk of ICSs in the geriatric population. Inspection of the mouth, monitoring of ocular pressure, and use of bone-protective drugs may be necessary in patients on prolonged ICS therapy. Above all, the use of the lowest possible ICS dose and a careful re-assessment of the inhalation procedure should be recommended. Taken together, these observations suggest that physicians should use ICSs appropriately for those patients in whom the benefit will outweigh the risk, especially chronic obstructive pulmonary disease (COPD) patients with previous frequent exacerbations. Given the paucity of information on the topic and the need to extrapolate the results from studies with broader age ranges, we strongly encourage the design of specifically tailored clinical studies in the elderly. Key PointsAsthma and chronic obstructive pulmonary disease (COPD) are inflammatory disorders of the airways. The pharmacological management of these chronic diseases is based on persistent and long-term use of inhaled corticosteroids (ICSs).Asthma and COPD are among the most common chronic diseases in clinical settings, and physicians are expected to diagnose and manage those diseases in the geriatric population on a daily basis. The management of chronic obstructive respiratory diseases in the geriatric population is complicated by the increased occurrence of comorbidities and associated treatment, and by age-associated physiological and structural changes of the lung.The chronic use of ICSs in the elderly is associated with the increased risk of local and systemic side effects such as candidiasis, cataract, glaucoma, diabetes mellitus, bone fractures, and pneumonia. Physicians should be aware of this in order to select those patients in whom the benefits will outweigh the risks.The online version of the original article can be found under

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“…121,122 The incidence also depends on the individual's age (particularly in children) and ethnic origin, with Hispanic people being more susceptible to development of PSCs. 121 However, the evidence of an association between ICS use and development of a PSC is equivocal and often confounded by previous exposure to oral corticosteroid therapy. Three studies have reported no association between long-term low-and high-dose ICS therapy in adults and the prevalence of PSCs.…”

Section: Adverse Eventsmentioning

confidence: 99%

Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta 2 agonists for the treatment of chronic asthma in children under the age of 12 years

2009

Clinical Governance: An International Journal

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Corticosteroid-induced cataracts

Cited by 310 publications

References 69 publications

Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over

Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over

Erratum to: Safety Considerations of Inhaled Corticosteroids in the Elderly

Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta 2 agonists for the treatment of chronic asthma in children under the age of 12 years

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