Corticosteroid inhibition of thermogenesis in obese animals

Bilateral Lesion of Hypothalamic Paraventricular Nucleus Abolishes Fever Induced by Endotoxin and Bradykinin in Ratsa

“…The results are in agreement with the observations that CRH antagonists or antibodies inhibit endotoxin‐ and cytokine‐induced fever. 4–7 In conclusion, these results give further support to the involvement of CRH in the febrile response induced by different pyrogens.…”

“…4,5 Inhibition of the action of CRH by central injection of a receptor antagonist (α‐helical CRF 9‐41 ) or a monoclonal antibody markedly attenuates the pyrogenic and thermogenic actions of several cytokines, including interleukin 1β (IL‐1β), IL‐6, and IL‐8. 4–7 These cytokines, in addition to being involved in different aspects of the immune and inflammatory response, also mediate the febrile response induced by endotoxin. 8…”

Genetic Obesity: Is the Defect in the Sympathetic Nervous System? A Review Through Developmental Studies in the Preobese Zucker Rat

“…The administration of corticosterone reverses most of the effects of adrenalectomy ( 134-136, 138, 139, 14 1). These data have led to a hypothesis which proposes that glucocorticoids acting in the central nervous system through inhibition of hypothalamic corticotropin-releasing factor secretion might be the cause of the development of this genetic obesity (142)(143)(144)(145). However, in marked contrast to what is observed in adult rats, if adrenalectomy is performed in 4-day-old pups, it does not prevent the emergence of obesity of fa/fa rats (146).…”

Ultrastructural alterations of rat brown adipocytes after short-term corticosterone treatment

“…Glucocorticoids, however, play a particularly interesting role in compounded the regulatory mechanisms of BAT thermogenesis. Namely, they are necessary, in a permissive sense, for coldinduced thermogenesis (Fellenz et al, 1982) but they strongly suppress dietinduced thermogenesis (Galpin et al, 1983a;Fukushima et al, 1985;York, 1989).…”