Corticosteroid Use and Periodontal Disease: A Systematic Review

Brasil-Oliveira, Rebeca; Cruz, Álvaro Augusto; Sarmento, Viviane Almeida; Souza‐Machado, Adelmir; Lins-Kusterer, Liliane

doi:10.1055/s-0040-1713954

Cited by 15 publications

(16 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adults older than 73 years showed a stronger association between periodontal disease and CDK (OR 3.74, 95% CI 3.49–3.97). Our findings in this study agree with those of other authors, 11–15 who identified a higher prevalence of periodontal disease in older adults. This situation represents a public health problem and places adults over 65 years of age at a 44% risk of acquiring periodontitis.…”

Section: Discussionsupporting

confidence: 94%

“…Studies evaluating the association between periodontal disease and chronic use of corticosteroids in patients with CKD could confirm this association. 13 Better understanding of these associations would inform clinical management of periodontal disease in patients with CKD.…”

Section: Discussionmentioning

confidence: 99%

“…3 It is possible that periodontal disease could precede progression of CKD. Thus, it is important to identify high-risk groups in whom progression of CKD could lead to severe sequelae such as renal failure [10][11][12][13] and death. [14][15][16][17] Timely diagnosis of periodontal disease in patients with CKD may inform clinical decision making.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults

Valenzuela-Narváez

et al. 2021

J Int Med Res

View full text Add to dashboard Cite

Objective The aim of this study was to evaluate periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults. Methods A total of 1159 adults aged 65 to 80 years and diagnosed with periodontal disease and CKD (stages 1, 2, and 3) were randomly selected for a cross-sectional study. Periodontal status was assessed using the Community Periodontal Index of Treatment Needs (CPITN) and CKD was staged using the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) guidelines. Results In patients with stage 1 CKD, the odds ratios (ORs) (95% confidence intervals [CIs]) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1.13 (0.83–1.55), 1.47 (1.13–1.81), 1, and 1, respectively. In patients with stage 2 CKD, the ORs (95% CIs) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1.49 (1.14–1.93), 1.37 (1.02–1.78), 3.07 (2.81–3.25), and 3.65 (3.49–3.71), respectively. In patients with stage 3 CKD, the ORs (95% CIs) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1, 1, 4.61 (4.47–5.21), and 5.23 (5.14–5.47), respectively. Conclusion The highest CPITN values (CPITN-3 and CPITN-4) were associated with CKD stages 2 and 3. Thus, periodontal disease may be associated with progression of CKD.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults

Valenzuela-Narváez

et al. 2021

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…There are few publications addressing the impact of corticosteroid treatment on periodontal disease, but one recent review concluded that some studies indicate an adverse effect of corticosteroids. 44 Furthermore, Fernandes et al found a positive association between the cumulative dose of corticosteroids and increase in plaque and gingival bleeding rates in patients with juvenile SLE (P = 0.01), whereas no association with the use of antimalarials or immunosuppressive agents was established. 45 Because corticosteroid treatment is part of the treatment regime for a majority of SLE patients, this could also contribute to the increased rate of periodontitis seen in the SLE-patients of our study.…”

Section: Discussionmentioning

confidence: 98%

Periodontitis in patients with systemic lupus erythematosus: A nationwide study of 1,990 patients

Bolstad

Sehjpal

Lie

et al. 2021

Journal of Periodontology

View full text Add to dashboard Cite

Background:The aim of this study was to examine the association between systemic lupus erythematosus (SLE) and periodontitis in Norway during a 10-year period from 2008 through 2017. Methods:In this population-based study, 1990 patients were included in the SLE-cohort based on diagnostic codes registered in the Norwegian Patient Registry. The control group (n = 170,332) comprised patients registered with diagnostic codes for non-osteoporotic fractures or hip or knee replacement because of osteoarthritis. The outcome was periodontitis, defined by procedure codes registered in the Control and Payment of Health Refunds database. Logistic regression analyses were performed to estimate odds ratio for periodontitis in patients versus controls adjusted for potential covariates. Results: Periodontitis was significantly more common in SLE patients compared to controls (OR 1.78, 95% CI 1.47-2.14) and the difference was highest in SLEpatients 20 to 30 years of age (OR 3.24, 95% CI 1.23 -8.52). The periodontitis rate in SLE patients was in the same range as for patients with diabetes mellitus type 2. Conclusions: Patients with SLE had an almost doubled risk of periodontitis compared with the control population, and the difference was most accentuated in the young patients. These findings warrant an increased focus on dental health in SLE-patients.

show abstract

“…A study that analyzed the effect of inhaled corticosteroids on a group of patients with chronic obstructive pulmonary disease concluded that this therapy may affect bone metabolism and cause a reduction in bone mineral density of the maxillary bones [34]. These observations were enforced by a meta-analysis that states that patients with asthma treated with corticosteroids have a higher prevalence of periodontitis compared to subjects under another therapeutic regime [35]. On the other hand, short-term use of corticosteroids might be beneficial for periodontal tissues; a study highlighted that prednisone, with or without the association of surgical therapy, was efficient in reducing inflammation periodontal parameters and salivary cortisol level in patients with chronic periodontitis [36].…”

Section: Corticosteroidsmentioning

confidence: 99%

The Effect of Acknowledged and Novel Anti-Rheumatic Therapies on Periodontal Tissues—A Narrative Review

et al. 2021

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) and periodontal disease (PD) are chronic complex inflammatory diseases with several common susceptibility factors, especially genetic and environmental risk factors. Although both disorders involve a perturbation of the immune–inflammatory response at multiple levels, one major difference between the two is the different locations in which they develop. RA is triggered by an exaggerated autoimmune response that targets joints, while periodontal disease occurs as a consequence of the subgingival periodontopathogenic microbiota. Current treatment models in both pathologies involve the stratification of patients to allow therapeutic individualization according to disease stage, complexity, progression, lifestyle, risk factors, and additional systemic diseases. Therapeutic guidelines for RA comprise of five main classes of drugs: non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, glucocorticoids, and disease-modifying anti-rheumatic drugs (DMARDs): biologic and non-biologic. Although various treatment options are available, a definitive treatment remains elusive, therefore research is ongoing in this area. Several alternatives are currently being tested, such as matrix metalloproteinases (MMP) inhibitors, toll-like receptors (TLR) blockers, pro-resolution mediators, anti-hypoxia inducing factors, stem cell therapy, NLRP3 inhibitors and even natural derived compounds. Although the link between PD and rheumatoid arthritis has been investigated by multiple microbiology and immunology studies, the precise influence and causality is still debated in the literature. Furthermore, the immunomodulatory effect of anti-rheumatic drugs on the periodontium is still largely unknown. In this narrative review, we explore the mechanisms of interaction and the potential influence that anti-rheumatoid medication, including novel treatment options, has on periodontal tissues and whether periodontal health status and treatment can improve the prognosis of an RA patient.

show abstract

Corticosteroid Use and Periodontal Disease: A Systematic Review

Cited by 15 publications

References 17 publications

Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults

Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults

Periodontitis in patients with systemic lupus erythematosus: A nationwide study of 1,990 patients

The Effect of Acknowledged and Novel Anti-Rheumatic Therapies on Periodontal Tissues—A Narrative Review

Contact Info

Product

Resources

About