Corticosteroids

Louis, Renaud; Schleich, Florence; Barnes, Peter J.

doi:10.1016/j.ccm.2012.05.004

Cited by 36 publications

(10 citation statements)

References 124 publications

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“…One of the most important results of this present study was the laser effect in reducing the levels of antibody IgE in serum of allergic animals. Some authors have also shown that LLLT reduces the IgE levels , but herein we demonstrated that LLLT applied since the beginning of the sensitization until the last antigenic challenge impairs the rise of IgE levels in serum at a period of 48 hours after challenge. Even if there is fluctuation in IgE levels during the time period before reaching the ends of 48 hours, the LLLT seems to provide an environment with a moderate response of both the immune system and the oxidative burst.…”

Section: Discussionmentioning

confidence: 99%

The chemokines secretion and the oxidative stress are targets of low‐level laser therapy in allergic lung inflammation

Carvalho

Brito

Oliveira

et al. 2016

Journal of Biophotonics

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Recent studies show that low-level laser therapy (LLLT) has an important anti-inflammatory action in acute lung inflammation. The present work explored if laser therapy is able to antagonize eosinophils and allergic inflammation induced by oxidative stress in Balb/c mice. Forty-eight hours after challenge, the leukocyte counting, ROS and nitrite/nitrate level, RANTES, CCL3, CCL8 as well as eotaxins were measured in the bronchoalveolar lavage fluid (BALF) of laser-treated mice or not. Into the lung, some chemokines receptors, the iNOS activity and mRNA expression, and the activities of superoxide dismutase (SOD), catalase, gluthatione, NADPH oxidase activities and thiobarbituric acid reactive species (T-Bars) were measured. Laser-treated allergic mice presented reduction of both the ICAM-1 and eosinophil in the lungs. RANTES, CCL8, CCL3 and eotaxins were reduced in BALF of laser-treated allergic mice. In allergic mice lung LLLT decreased the CCR1 and CCR3 and restored the oxidative stress balance as well. Laser decreased the lipidic peroxidation in allergic mice lung as much as increased SOD, GPx and GR. It shows that LLLT on allergic lung inflammation involves leukocyte-attractant chemokines and endogenous antioxidant. Based on results, LLLT may ultimately become a non- invasive option in allergic lung disease treatment. The top figure illustrates the laser decreasing the eosinophils migration into BALF and the bottom figure shows the laser upregulating the expression of heme-oxygenase (anti-oxidant enzyme) in lung tissue anti-oxidant.

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Section: Discussionmentioning

confidence: 99%

The chemokines secretion and the oxidative stress are targets of low‐level laser therapy in allergic lung inflammation

Carvalho

Brito

Oliveira

et al. 2016

Journal of Biophotonics

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“…As we all know, corticosteroid is the most effective treatment for controlling allergic inflammation. But the ability of corticosteroid to prevent airway remodeling is controversial [30]. So T0901317 could be potentially used in combination with glucocorticoids in asthma treatment.…”

Section: Discussionmentioning

confidence: 99%

A Liver-X-Receptor Ligand, T0901317, Attenuates IgE Production and Airway Remodeling in Chronic Asthma Model of Mice

Shi

Tan

et al. 2014

PLoS ONE

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The liver-X-receptors have shown anti-inflammatory ability in several animal models of respiratory disease. Our purpose is to investigate the effect of LXR ligand in allergen-induced airway remodeling in mice. Ovalbumin-sensitized mice were chronically challenged with aerosolized ovalbumin for 8 weeks. Some mice were administered a LXR agonist, T0901317 (12.5, 25, 50 mg/kg bodyweight) before challenge. Then mice were evaluated for airway inflammation, airway hyperresponsiveness and airway remodeling. T0901317 failed to attenuate the inflammatory cells and Th2 cytokines in bronchoalveolar lavage fluid. But the application of T0901317 reduced the thickness of airway smooth muscle and the collagen deposition. Meanwhile, T0901317 treatment evidently abolished the high level of OVA-specific IgE, TGF-β1 and MMP-9 in lung. So LXRs may attenuate the progressing of airway remodeling, providing a potential treatment of asthma.

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“…1 Whereas the majority of patients with asthma are effectively treated with current standard therapy (eg, high doses of ICS with LABA), 5 some patients do not adequately respond to standard therapy and need novel treatment approaches or adjunct therapies. 6 , 7 AHP has been traditionally and frequently used to treat asthma in East Asian countries, including China and Taiwan. 48 , 49 This therapy uses a processed herbal medicine patch that is strategically placed on specific acupoints for a range of diseases, including asthma.…”

Section: Discussionmentioning

confidence: 99%

“… 5 Therefore, novel treatment approaches or adjunct therapies are necessary for both inflammation and bronchoconstriction in patients with steroid-dependent or steroid-resistant asthma. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%