Corticosteroids and Antibiotics in Adult Respiratory Distress Syndrome: A Review

Luce, John M.; Pierson, David J.

doi:10.1055/s-2007-1012152

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Endotoxemia: Influences Of Anti-inflammatory Agents1

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1983

1993

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Cited by 6 publications

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“…Although glucocorticosteroids (such as methylprednisolone) are not of proven value in treatment of primary pulmonary edema, 34 studies from our laboratory 35 and elsewhere 36 indicate that treatment of sheep with methylprednisolone (30 mg/kg) before or soon after endotoxemia can significantly attenuate the course of lung vascular injury. High dose corticosteroids may prevent liberation of free arachidonic acid and thereby inhibit formation of lipoxygenase and cyclooxygenase products, 37 but effects of corticosteroids on release of arachidonic acid metabolites have not yet been evaluated in sheep given endotoxin.…”

Section: Endotoxemia: Influences Of Anti-inflammatory Agentsmentioning

confidence: 92%