2004
DOI: 10.1097/00000542-200405000-00004
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Corticosteroids and Inhaled Salbutamol in Patients with Reversible Airway Obstruction Markedly Decrease the Incidence of Bronchospasm after Tracheal Intubation

Abstract: : Pretreatment with either salbutamol alone or salbutamol combined with methylprednisolone significantly and similarly improves lung function within 1 day. However, only combined salbutamol-methylprednisolone pretreatment decreases the incidence of wheezing after tracheal intubation. Therefore, in patients with bronchial hyperreactivity, preoperative treatment with combined corticosteroids and salbutamol minimizes intubation-evoked bronchoconstriction much more effectively than the inhaled beta2-sympathomimeti… Show more

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Cited by 114 publications
(57 citation statements)
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“…Ideally, patients should be symptoms-free with a peak expiratory flow greater than 80% of the predicted or personal best value before surgery [56]. A short course of systemic corticosteroid (e.g., oral prednisone 0.5–1 mg/kg or equivalent), starting from 1 to 2 days before surgery, should be given to patients at risk for PPCs [57]. The perioperative use of systemic corticosteroid has not been found to increase respiratory infection or delay wound healing among asthmatic patients [58, 59].…”
Section: Risk Factors For Ppcsmentioning
confidence: 99%
“…Ideally, patients should be symptoms-free with a peak expiratory flow greater than 80% of the predicted or personal best value before surgery [56]. A short course of systemic corticosteroid (e.g., oral prednisone 0.5–1 mg/kg or equivalent), starting from 1 to 2 days before surgery, should be given to patients at risk for PPCs [57]. The perioperative use of systemic corticosteroid has not been found to increase respiratory infection or delay wound healing among asthmatic patients [58, 59].…”
Section: Risk Factors For Ppcsmentioning
confidence: 99%
“…Ketamine also could be considered for its bronchodilator properties. However, due to significant sympathomimetic effects of ketamine in a presence of SVT, we decided to avoid it [4].…”
Section: Discussionmentioning
confidence: 99%
“…In newly diagnosed or non-compliant patients, 40 mg of oral methyl prednisolone may be given for 5 days prior to surgery [32]. Prophylactic systemic steroid therapy is also recommended in patients with a history of systemic steroid therapy within the last 6 months [33].…”
Section: Preoperative Evaluation In Special Situations 1) Asthmamentioning
confidence: 99%