Corticosteroids for prevention of restenosis after Angioplasty

Beránek, Jaroslav

doi:10.1002/ccd.1810200117

Cited by 4 publications

(1 citation statement)

References 12 publications

(7 reference statements)

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“…In both fibroses, fibroblastic cells derive from undifferentiated vascular endothelial cells [ 13,141. Provided this concept is correct, both fibroses are also subjected to the same growth stimulation [12] and growth inhibition [15,6]. There is little doubt left that a most powerful growth stimulator of the hypertrophic scar is a hypoxia [16] induced by a poor regeneratioof its afferent and efferent vessels [17].…”

Section: To the Editormentioning

confidence: 99%

Why restenosis after angioplasty appears and why it has been so difficult to prevent

Beránek

Hack²,

Cheng

1990

Cathet. Cardiovasc. Diagn.

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Section: To the Editormentioning

confidence: 99%

Why restenosis after angioplasty appears and why it has been so difficult to prevent

Beránek

Hack²,

Cheng

1990

Cathet. Cardiovasc. Diagn.

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Antiangiogenesis: A suitable preventive treatment of restenosis

Beránek

1993

Cathet. Cardiovasc. Diagn.

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Coronary aneurysms after stent placement: A suggestion of altered vessel wall healing in the presence of anti-inflammatory agents

Rab¹,

King²,

Roubin³

et al. 1991

Journal of the American College of Cardiology

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Coronary aneurysms are rare after conventional angioplasty and have not been reported after coronary stenting. Coronary artery stent sites were examined by follow-up angiography at a median of 4 months in 29 patients who received the Cook stent (Gianturco-Roubin) for acute coronary closure. Nineteen patients were treated with glucocorticoids administered intravenously or orally, or both, with or without colchicine and results were compared with those in 10 patients who were treated with neither agent. Standard therapy for all patients included routine administration of aspirin and heparin before and warfarin sodium (Coumadin) and aspirin after stent placement. Most patients also received dipyridamole and lovastatin during the follow-up period. Compliance with medications was confirmed by telephone conversation with each patient. Six (32%) of the 19 stented arteries showed evidence of coronary artery aneurysm, defined as expansion of the lumen outside the margins of the stent. None of the patients in the control group (who did not receive steroids or colchicine) developed aneurysm. This pattern of altered vascular healing in stented coronary segments appears to be due to the addition of multiple anti-inflammatory drugs rather than to stent presence alone. This observation demonstrates the possibility of medical impairment of normal vascular remodeling after acute injury and stent placement, which may be of benefit in designing future trials on restenosis.

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Corticosteroids for prevention of restenosis after Angioplasty

Cited by 4 publications

References 12 publications

Why restenosis after angioplasty appears and why it has been so difficult to prevent

Why restenosis after angioplasty appears and why it has been so difficult to prevent

Antiangiogenesis: A suitable preventive treatment of restenosis

Coronary aneurysms after stent placement: A suggestion of altered vessel wall healing in the presence of anti-inflammatory agents

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