2017
DOI: 10.1136/bmj.j3887
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Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials

Abstract: Objective To estimate the benefits and harms of using corticosteroids as an adjunct treatment for sore throat. Design Systematic review and meta-analysis of randomised control trials. Data sources Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), trial registries up to May 2017, reference lists of eligible trials, related reviews. Study selection Randomised controlled trials of the addition of corticosteroids to standard clinical care for patients aged 5 or older in emergency departmen… Show more

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Cited by 62 publications
(54 citation statements)
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References 35 publications
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“…Convergent frameworks are frequent in the health sciences, where inclusion criteria are typically more restrictive and the relevant constructs and measures are likely to be more tightly defined than in other disciplines . A prototypical example is a review of clinical trials of a particular treatment for patients with a particular condition that examines only the outcomes most important to patients …”
Section: Defining the Research Question And Setting Eligibility Criteriamentioning
confidence: 99%
See 1 more Smart Citation
“…Convergent frameworks are frequent in the health sciences, where inclusion criteria are typically more restrictive and the relevant constructs and measures are likely to be more tightly defined than in other disciplines . A prototypical example is a review of clinical trials of a particular treatment for patients with a particular condition that examines only the outcomes most important to patients …”
Section: Defining the Research Question And Setting Eligibility Criteriamentioning
confidence: 99%
“…11 A prototypical example is a review of clinical trials of a particular treatment for patients with a particular condition that examines only the outcomes most important to patients. 12 In contrast, divergent frameworks tend to take an exploratory approach. They address a broad research question with a primary focus on identifying sources of variation among effect sizes that are expected to show substantial statistical heterogeneity such that interpretation of an overall mean effect size might be challenging, or even meaningless.…”
Section: Defining the Research Question And Setting Eligibility Crimentioning
confidence: 99%
“…As shown in Table 1, impact factors of journals with included publications ranged from 17.2 to 47.8 in general medicine, 11.9 to 24.0 in oncology, 19.3 to 19.9 in cardiology, 10.3 to 10.6 in respiratory medicine, 11.9 to 19.7 in endocrinology, 16.7 to 18.4 in gastroenterology, and 6.3 for the Cochrane Database of Systematic Reviews. The 29 selected meta-analyses evaluated a broad spectrum of pharmacological interventions, including 11 on treatment efficacy [24,29,33,35,36,40,42,[44][45][46][47], 2 on harms [31,50], and 16 [23, 25, 28, 30, 32, 34, 37-39, 41, 43, 48, 49, 51] on both efficacy and harms. Between 2 and 522 RCTs were included in each meta-analysis.…”
Section: Article Selectionmentioning
confidence: 99%
“…As shown in Tables 1 and 2 of 29 (6.9%) included metaanalyses, both published in specialty journals [34,43], reported receiving pharmaceutical industry funding, 11 (37.9%) reported non-industry funding [23, 26, 29-32, 35, 40, 49-51], 3 reported no study funding (10.3%) [28,33,46], and the funding source of 13 (44.8%) was not reported [24, 25, 27, 36-39, 41, 42, 44, 45, 47, 48]. Meta-analysis funding sources were reported for 8 of 11 meta-analyses from general medicine journals (72.7%) [23,26,[28][29][30][31][32][33], 5 of 15 (33.3%) from specialty medicine journals [34,35,40,43,46], and all 3 (100%) Cochrane reviews [49][50][51].…”
Section: Study Funding and Author-industry Financial Ties Of Metaanalmentioning
confidence: 99%
“…After conducting a systematic review and meta-analysis that included data from the April trial,3 the Rapid Recommendation authors make a weak recommendation to use a single dose of oral corticosteroids in patients presenting with acute sore throat. The recommendation applies across ages but excludes patients under 5 years old.…”
mentioning
confidence: 99%