Corticosteroids for viral myocarditis

Chen, HS; Yang, Min; Jp, Liu

doi:10.1002/14651858.cd004471

Cited by 36 publications

(37 citation statements)

References 14 publications

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“…In stark contrast to these results are studies that delineate viral and non-viral lymphocytic myocarditis etiologies. It has become increasingly clear that immunosuppressive treatments for viral myocarditis are not beneficial (Chen, Wang, Wu, & Liu, 2013), in contrast a retrospective study conducted by Frustaci and colleagues observed that a six month prednisone-azathioprine treatment resulted in improved left ventricle ejection fraction in the subset of patients with myocarditis characterized by a lack of viral genome in the myocardium and presence of cardiac auto-antibodies (Frustaci, et al, 2003). The group followed up this research in a randomized double-blind placebo-controlled study.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Emerging pharmacologic targets and treatments for myocarditis

Jensen

Marchant

2016

Pharmacology & Therapeutics

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Section: Accepted Manuscriptmentioning

confidence: 99%

Emerging pharmacologic targets and treatments for myocarditis

Jensen

Marchant

2016

Pharmacology & Therapeutics

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“…Revisão sistemática de ensaios clínicos controlados e aleatorizados (RCT) que avaliaram doentes (crianças ou adultos) com miocardite viral (aguda ou crónica; sem a obrigatoriedade de diagnóstico definitivo por biópsia miocárdica, tal como acontece no mundo real 2 ), aleatorizados para terapêutica com corticosteroides ou para um dos seguintes grupos controlo: placebo, terapêutica de suporte, ausên-cia de tratamento, terapêutica antiviral ou terapêutica convencional 1 A extração e avaliação dos dados foram realizadas independentemente por dois autores.…”

Section: Tipo E Descrição Do Estudounclassified

Cochrane Corner – administração de corticosteroides para miocardite de etiologia viral

Caldeira¹,

Lopes²,

Vaz‐Carneiro³

et al. 2015

Revista Portuguesa de Cardiologia

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The causes of myocarditis are diverse, but a viral etiology is the most common. In this systematic review by the Cochrane Collaboration, the authors assessed the efficacy of corticosteroid therapy in patients with viral myocarditis. Eight randomized controlled trials with 719 patients (two trials in pediatric populations) were included for analysis. Pooled results did not show significant differences in mortality with the use of corticosteroids. Patients on corticosteroid therapy had significantly higher post-treatment left ventricular ejection fraction values compared to control. These results are limited by the significant heterogeneity associated with clinical trials. The best available evidence does not support the routine use of corticosteroids in patients with viral myocarditis.

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“…In severe cases mechanical ventricular assist device support is necessary until resolution or cardiac transplantation is available [199]. Although immunosuppressive medicines including corticosteroids were applied in many studies with viral myocarditis, meta-analyses have shown that their effects remain controversial since they do not reduce mortality [37]. In a systematic review, the use of intravenous immunoglobulins (IVIGs) in viral myocarditis was not recommended [38].…”

Section: The Use Of Antivirals Is Limited In Non-herpetic Viral Nervomentioning

confidence: 99%

How to approach and treat viral infections in ICU patients

et al. 2014

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Patients with severe viral infections are often hospitalized in intensive care units (ICUs) and recent studies underline the frequency of viral detection in ICU patients. Viral infections in the ICU often involve the respiratory or the central nervous system and can cause significant morbidity and mortality especially in immunocompromised patients. The mainstay of therapy of viral infections is supportive care and antiviral therapy when available. Increased understanding of the molecular mechanisms of viral infection has provided great potential for the discovery of new antiviral agents that target viral proteins or host proteins that regulate immunity and are involved in the viral life cycle. These novel treatments need to be further validated in animal and human randomized controlled studies.

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Corticosteroids for viral myocarditis

Cited by 36 publications

References 14 publications

Emerging pharmacologic targets and treatments for myocarditis

Emerging pharmacologic targets and treatments for myocarditis

Cochrane Corner – administração de corticosteroides para miocardite de etiologia viral

How to approach and treat viral infections in ICU patients

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