Corticosteroids in Herpes Simplex and Zoster

Smith, Edgar B.; Powell, Ralph F.

doi:10.1111/j.1365-4362.1975.tb00122.x

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Corticosteroids decrease cell-mediated immunity, thus raising concern about the reactivation of latent VZV in terminal ganglia. Smith et al 11 argue that relatively large doses of corticosteroids are required for this to occur. Others have noted that reactivation from topical steroid preparations is unlikely, citing evidence of few side effects from use of oral injections of triamcinolone in patients with herpes labialis and stomatitis.…”

Section: Discussionmentioning

confidence: 99%

Herpes zoster infection after topical steroid use in the setting of tumid lupus erythematosus

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Herpes zoster infection after topical steroid use in the setting of tumid lupus erythematosus

et al. 2018

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“…In the cornea in particular, therapeutics are used off-label to manage corneal angiogenesis, given the current lack of approved treatments specific for the cornea. Corticosteroids and/or nonsteroidal anti-inflammatory drugs (NSAIDs) are used to target neovascularisation 6 , 7 , however, steroids may promote infection 8 , 9 , glaucoma 10 , cataract 11 , and herpes simplex recurrence 12 , 13 while NSAIDs are reported to cause corneal ulceration and melting 14 .…”

Section: Background and Summarymentioning

confidence: 99%

Genome-wide expression datasets of anti-VEGF and dexamethasone treatment of angiogenesis in the rat cornea

et al. 2017

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Therapeutics against pathologic new blood vessel growth, particularly those targeting vascular endothelial growth factor (VEGF) are of enormous clinical interest. In the eye, where anti-VEGF agents are in widespread clinical use for treating retinal and corneal blindness, only partial or transient efficacy and resistance to anti-VEGF agents are among the major drawbacks. Conversely, corticosteroids have long been used in ophthalmology for their potency in suppressing inflammation and angiogenesis, but their broad biological activity can give rise to side effects such as glaucoma and cataract. To aid in the search for more targeted and effective anti-angiogenic therapies in the eye, we present here a dataset comparing gene expression changes in dexamethasone versus anti-Vegfa treatment of inflammation leading to angiogenesis in the rat cornea. Global gene expression analysis with GeneChip Rat 230 2.0 microarrays was conducted and the metadata submitted to Expression Omnibus repository. Here, we present a high-quality validated dataset enabling genome-wide comparison of genes differentially targeted by dexamethasone and anti-Vegf treatments, to identify potential alternative therapeutic targets for evaluation.

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Complement Components in Recurrent Genital Herpes Simplex

1981

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Complement components 1,2,3,4 and total complement hemolytical activity CH50 were studied in 39 patients with serve recurrent genital herpes simplex. The results show statistically significant and selective diminution of C4 (P>0.001) The other components were normal. C4 has a specific action against herpesvirus by itself or associated to some other elements over C4 failure, local or systemic disturbances alter the homeostasis of specific and nonspecific immune system, provking a disbalance host‐virus which would explain the recurrence.

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Corticosteroids in Herpes Simplex and Zoster

Cited by 3 publications

References 29 publications

Herpes zoster infection after topical steroid use in the setting of tumid lupus erythematosus

Herpes zoster infection after topical steroid use in the setting of tumid lupus erythematosus

Genome-wide expression datasets of anti-VEGF and dexamethasone treatment of angiogenesis in the rat cornea

Complement Components in Recurrent Genital Herpes Simplex

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