Corticosteroids or Not for Postoperative Nausea: A Double-Blinded Randomized Study

Nordin, Lena; Nordlund, Anders; Lindqvist, Andreas; Gíslason, Hjörtur; Hedenbro, Jan

doi:10.1007/s11605-016-3166-3

Cited by 9 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparable results were attained in patients undergoing ambulatory surgery 183 and elective breast surgery 184 and in high-risk cardiac surgical patients 185 . However, in a placebo-controlled study by Nordin et al 186 comparing betamethasone 8 mg per os (PO) and betamethasone 8 mg IV when administered 1 hour before induction of anesthesia in patients undergoing elective Roux-y-gastric bypass, betamethasone was of limited benefit in preventing PONV.…”

Section: Tricyclic Antidepressantsmentioning

confidence: 99%

“…However, in a placebo-controlled study by Nordin et al . 186 comparing betamethasone 8 mg per os (PO) and betamethasone 8 mg IV when administered 1 hour before induction of anesthesia in patients undergoing elective Roux-y-gastric bypass, betamethasone was of limited benefit in preventing PONV.…”

Section: Perioperative Antiemetic Drugs Used For the Treatment And/ormentioning

confidence: 99%

See 1 more Smart Citation

Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review

et al. 2020

View full text Add to dashboard Cite

Postoperative nausea and vomiting (PONV) and postdischarge nausea and vomiting (PDNV) remain common and distressing complications following surgery. The routine use of opioid analgesics for perioperative pain management is a major contributing factor to both PONV and PDNV after surgery. PONV and PDNV can delay discharge from the hospital or surgicenter, delay the return to normal activities of daily living after discharge home, and increase medical costs. The high incidence of PONV and PDNV has persisted despite the introduction of many new antiemetic drugs (and more aggressive use of antiemetic prophylaxis) over the last two decades as a result of growth in minimally invasive ambulatory surgery and the increased emphasis on earlier mobilization and discharge after both minor and major surgical procedures (e.g. enhanced recovery protocols). Pharmacologic management of PONV should be tailored to the patient’s risk level using the validated PONV and PDNV risk-scoring systems to encourage cost-effective practices and minimize the potential for adverse side effects due to drug interactions in the perioperative period. A combination of prophylactic antiemetic drugs with different mechanisms of action should be administered to patients with moderate to high risk of developing PONV. In addition to utilizing prophylactic antiemetic drugs, the management of perioperative pain using opioid-sparing multimodal analgesic techniques is critically important for achieving an enhanced recovery after surgery. In conclusion, the utilization of strategies to reduce the baseline risk of PONV (e.g. adequate hydration and the use of nonpharmacologic antiemetic and opioid-sparing analgesic techniques) and implementing multimodal antiemetic and analgesic regimens will reduce the likelihood of patients developing PONV and PDNV after surgery.

show abstract

Section: Tricyclic Antidepressantsmentioning

confidence: 99%

Section: Perioperative Antiemetic Drugs Used For the Treatment And/ormentioning

confidence: 99%

Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In fact, according to a study conducted by Suh et al, nausea and vomiting that occurred after LSG caused prolonged hospital stays and an increased number of emergency department visits after discharge from the hospital [29]. While some studies recommend using prophylactic pharmacological agents to prevent postoperative nausea and vomiting, others recommend other agents for treatment [30][31][32][33]. Nevertheless, it is evident that there is not yet a consensus in the literature concerning the solution to the problem in question.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Paragastric Neural Blockade in Controlling Pain, Nausea, and Vomiting After Sleeve Gastrectomy: A Randomized Controlled Trial

Katar,

Turan

2024

OBES SURG

View full text Add to dashboard Cite

Background There are difficulties in controlling the symptoms of pain, nausea, and vomiting after laparoscopic sleeve gastrectomy (LSG). This study aimed to evaluate the efficacy and safety of PGNB on pain and nausea and vomiting in the early postoperative period in patients who underwent LSG. Methods In this prospective, randomized, controlled, double-blind study, the patients were divided into two equally formed groups: patients who underwent PGNB after LSG and the control group. Postoperative pain symptoms were evaluated using the visual analog scale (VAS) scores, and nausea and vomiting symptoms were evaluated using the postoperative nausea and vomiting (PONV) scores. Results The study was completed with 90 patients, 45 patients in each group. The VAS scores measured at postoperative hours 1, 6, and 12 were statistically significantly lower in the PGNB group. There was no significant difference between the two groups in terms of the 24th hour VAS scores. The mean PONV scores of the PGNB and control groups were 0.47 ± 0.89 and 1.67 ± 1.95, respectively, revealing a significantly higher value for the controls. The mean time to first mobilization in the postoperative period was significantly shorter in the PGNB group. Upon the evaluation of patient satisfaction, it was determined that the satisfaction score of the PGNB group was significantly higher. Conclusions PGNB is an effective and safe method for managing pain, nausea, and vomiting that occur in the early period after LSG. Graphical Abstract

show abstract

“…The use of antiemetics can reduce the occurrence of PONV from over 52% to less than 30% in certain populations [ 1 , 13 ]. To decrease the incidence of PONV, a number of antiemetics including antihistamines [ 14 ], butyrophenones [ 14 , 15 ], serotonin receptor antagonists, corticosteroids [ 16 ], and anaesthetic agents [ 17 ] have been tried in clinical use. Nevertheless, most of the antiemetics are associated with undesirable adverse effects, such as sedation, hypotension, dysphoria, dry mouth, restlessness, and extrapyramidal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Propofol versus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Ear, Nose, and Throat Surgery in Tikur Anbessa Specialized Hospital and Yekatit 12th Hospital, Addis Ababa, Ethiopia

Bantie

Admasu

Mulugeta

et al. 2020

Anesthesiology Research and Practice

View full text Add to dashboard Cite

Background. Postoperative nausea and vomiting (PONV) remain as common and unpleasant and highly distressful experience following ear, nose, and throat surgery. During ENT surgery, the incidence of PONV could be significantly reduced in patients who receive dexamethasone and propofol as prophylaxis. However, the comparative effectiveness of the two drugs has not been assessed. The aim of this study was to compare the effectiveness of propofol and dexamethasone for prevention of PONV in ear, nose, and throat surgery. Methods. This study was conducted in 80 patients, with ASA I and II, aged 18–65 years, and scheduled for ENT surgery between December 20, 2017, and March 20, 2018. Patients were randomly assigned to Group A and Group B. Immediately after the procedure, Group A patients received single dose of intravenous (IV) dexamethasone (10 mg/kg) and Group B patients were given propofol (0.5 mg/kg, IV), and equal follow-up was employed. The incidence of PONV was noted at 6th, 12th, and 24th hour of drug administration. Independent t-test and Mann–Whitney test were used for comparison of symmetric numerical and asymmetric data between groups, respectively. Categorical data were analyzed with the chi-square test, and p value of < 0.05 was considered as level of significance. Results. The incidences of PONV throughout the 24-hour postoperative period were 35% in the propofol group and 25% in the dexamethasone group. Statistical significance was found in incidence of PONV (0% versus 22.5%) and use of antiemetic (0% versus 5%) between dexamethasone and propofol groups, respectively, at 12–24 hours. Over 24 hours, 5% in dexamethasone group and 12.5% in propofol group developed moderate PONV, while none of the participants felt severe PONV. Conclusions. Dexamethasone was more effective than propofol to prevent PONV with lower requirements of rescue antiemetics.

show abstract

Corticosteroids or Not for Postoperative Nausea: A Double-Blinded Randomized Study

Cited by 9 publications

References 22 publications

Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review

Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review

Efficacy and Safety of Paragastric Neural Blockade in Controlling Pain, Nausea, and Vomiting After Sleeve Gastrectomy: A Randomized Controlled Trial

Effectiveness of Propofol versus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Ear, Nose, and Throat Surgery in Tikur Anbessa Specialized Hospital and Yekatit 12th Hospital, Addis Ababa, Ethiopia

Contact Info

Product

Resources

About