Corticosteroids: The Mainstay in Asthma Therapy.

Abstract

For Abstract see ChemInform Abstract in Full Text.

Changes in the proteome of human bronchial epithelial cells following stimulation with leucotriene E4 and transforming growth factor‐β1

“…The former belongs to the Hsp90 protein family of molecular chaperones, best known for their association with a variety of signal transduction systems 28 . Hsp90 functions in complexes with steroid hormone receptors, 29,30 among which the GR has a special relevance to asthma. Because inhaled glucocorticoids are by far the most effective drugs for asthma treatment, 29 and as Hsp90 appears to be necessary for binding of glucocorticoids to the GR, 31 one may speculate in light of the present results that downregulation of Hsp90α by LTE 4 may cause inactivation or even downregulation of GR.…”

Tolerability Profiles of Leukotriene Receptor Antagonists and Long-Acting β2-Adrenoceptor Agonists in Combination with Inhaled Corticosteroids for Treatment of Asthma: A Review

“…Thus, antileukotriene therapies have been developed either to inhibit leukotriene synthesis (via 5-lipooxygenase inhibition) or to block the cysLT receptor by LTRA. Corticosteroids generally reduce in vitro cysLT production, most likely through inhibition of phospholipase (109). However, there is evidence to suggest that corticosteroids block only in part the in vivo biosynthesis of cysLTs (111).…”

“…In these cases, either LTRAs or LABAs can be considered for add-on 418 R. COLUCCI ET AL. therapy to ICS (109). Several mechanisms have been considered to explain the synergistic effects of these combination therapies.…”

Glucocorticosteroids in football: use and misuse: Figure 1

“…12 Inhaled glucocorticosteroids are used for treatment of bronchial asthma, for which they provide highly effective first line treatment. [49][50][51] To minimise the degree of systemic exposure and eliminate associated systemic and local adverse effects, one study used the ''soft drug approach'' to deliver potent anti-inflammatory agents close to their site of reaction. 49 However, the prescription of high dose inhalational glucocorticosteroids, particularly fluticasone, should be critically analysed, as life threatening adrenal failure has been reported in asthmatic children inhaling glucocorticosteroids.…”